The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Structural studies reveal the molecular mechanism of PET ase
Abstract
Poly(ethylene terephthalate) (PET) is a class of plastic material widely used in modern society, but large amounts of PET waste cause severe environmental problems. Obtained from a PET‐consuming bacterium Ideonella sakaiensis, the enzyme PET ase exhibits superb hydrolytic activity and substrate preference toward PET. Here, we summarize some recent advances in the crystallographic analysis of PET ase. These reports uncover structural features of PET ase that are involved in its catalytic activity. In comparison to homologous enzymes, PET ase contains an additional disulfide bond as well as an extended β8‐α6 loop. More importantly, the crystal structures of PET ase in complex with substrate and product analogs provide critical information for understanding the mechanism of action of PET ase. In particular, the wobbling conformation of W156 is closely related to the binding of substrate and product. These new findings are of great importance for further in‐depth research and engineering development of PET ase, and should advance the implementation of plastic biodegradation strategy.
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Cites
A bacterium that degrades and assimilates poly(ethylene terephthalate)
Yoshida, S., Hiraga, K., Takehana, T., Taniguchi, I., Yamaji, H., Maeda, Y., Toyohara, K., Miyamoto, K., Kimura, Y., & Oda, K. (2016) · Science · doi:10.1126/science.aad6359 · Cited by 3,367
Cited by
Microbial degradation of microplastics by enzymatic processes: a review
Othman, A. R., Hasan, H. A., Muhamad, M. H., Ismail, N. ’., & Abdullah, S. R. S. (2021) · Environmental Chemistry Letters · doi:10.1007/s10311-021-01197-9 · Cited by 426
Mechanism-Based Design of Efficient PET Hydrolases
Wei, R., von Haugwitz, G., Pfaff, L., Mican, J., Badenhorst, C. P. S., Liu, W., Weber, G., Austin, H. P., Bednar, D., Damborsky, J., et al. (2022) · ACS Catalysis · doi:10.1021/acscatal.1c05856 · Cited by 284
Self-citationKawai, F., Kawabata, T., & Oda, M. (2020) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.0c01638 · Cited by 259
Edwards, S., León-Zayas, R., Ditter, R., Laster, H., Sheehan, G., Anderson, O., Beattie, T., & Mellies, J. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105612 · Cited by 67
Metadata
- Authors
- Chen, C., Han, X., Ko, T., Liu, W., & Guo, R.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2018-08-17
- Volume
- 285
- Issue
- 20
- Pages
- 3717-3723
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2883813712
- Cited by
- 166
- References
- 1
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, C., Han, X., Ko, T., Liu, W., & Guo, R. (2018). Structural studies reveal the molecular mechanism of PET ase. The FEBS Journal. https://doi.org/10.1111/febs.14612
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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