Urea-containing topical formulations

Atopic Dermatitis

Williams, H. C., Leung, D. Y. M., Thestrup‐Pedersen, K., & David, T. J. (2000) · Cited by 4,597 · see citing works

Global Epidemiology of Psoriasis: A Systematic Review of Incidence and Prevalence

Parisi, R., Symmons, D. P. M., Griffiths, C. E. M., & Ashcroft, D. M. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.339 · Cited by 2,601 · see citing works

Atopic Dermatitis

Bieber, T. (2008) · New England Journal of Medicine · doi:10.1056/nejmra074081 · Cited by 1,780 · see citing works

Application of moisturizer to neonates prevents development of atopic dermatitis

Horimukai, K., Morita, K., Narita, M., Kondo, M., Kitazawa, H., Nozaki, M., Shigematsu, Y., Yoshida, K., Niizeki, H., Motomura, K.-I., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.07.060 · Cited by 607 · see citing works

Emollients and moisturisers for eczema

van Zuuren, E. J., Fedorowicz, Z., Christensen, R., Lavrijsen, A. P. M., & Arents, B. W. M. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012119.pub2 · Cited by 266 · see citing works

Improvement in skin barrier function in patients with atopic dermatitis after treatment with a moisturizing cream (Canoderm®)

Lodén, Andersson, A., & LINDBERG (1999) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1999.02660.x · Cited by 230 · see citing works

Stratum corneum hydration and amino acid content in xerotic skin

Horii, I., NAKAYAMA, Y., OBATA, M., & Tagami, H. (1989) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1989.tb08190.x · Cited by 213 · see citing works

Barrier dysfunction in the skin allergy

Egawa, G., & Kabashima, K. (2017) · Allergology International · doi:10.1016/j.alit.2017.10.002 · Cited by 196 · see citing works

Treatment with a barrier‐strengthening moisturizing cream delays relapse of atopic dermatitis: a prospective and randomized controlled clinical trial

Wirén, K., Nohlgård, C., Nyberg, F., Holm, L., Svensson, M., Johannesson, A., Wallberg, P., Berne, B., Edlund, F., & Lodén, M. (2009) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2009.03303.x · Cited by 158 · see citing works

Topical urea in skincare: A review

Celleno, L. (2018) · Dermatologic Therapy · doi:10.1111/dth.12690 · Cited by 151 · see citing works

Randomized Controlled Trial of the Prophylactic Effect of Urea-Based Cream on Sorafenib-Associated Hand-Foot Skin Reactions in Patients With Advanced Hepatocellular Carcinoma

Ren, Z.-G., Zhu, K.-S., Kang, H., Lu, M.-Q., Qu, Z., Lu, L., Song, T.-Q., Zhou, W.-P., Wang, H., Yang, W., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2013.52.9651 · Cited by 149 · see citing works

Topical drug classification

Buhse, L., Kolinski, R., Westenberger, B., Wokovich, A., Spencer, J., Chen, C. W., Turujman, S., Gautam-Basak, M., Kang, G. J., Kibbe, A., et al. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.01.032 · Cited by 115 · see citing works

Urea: a comprehensive review of the clinical literature

Pan, M., Heinecke, G. M., Bernardo, S. G., et al. (2013) · Dermatology Online Journal · doi:10.5070/d31911020392 · Cited by 112 · see citing works

Topical treatment by urea reduces epidermal hyperproliferation and induces differentiation in psoriasis.

Hagemann, I. S., & Proksch, E. (1996) · Acta Dermato Venereologica · doi:10.2340/0001555576353356 · Cited by 103 · see citing works

A Guide to Topical Vehicle Formulations

Mayba, J. N., & Gooderham, M. (2017) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/1203475417743234 · Cited by 92 · see citing works

Clinical Effectiveness of Moisturizers in Atopic Dermatitis and Related Disorders: A Systematic Review

Lindh, J. D., & Bradley, M. (2015) · American Journal of Clinical Dermatology · doi:10.1007/s40257-015-0146-4 · Cited by 87 · see citing works

Comparison of Moisturizing Creams for the Prevention of Atopic Dermatitis Relapse: A Randomized Double-blind Controlled Multicentre Clinical Trial

Åkerström, U., Reitamo, S., Langeland, T., Berg, M., Rustad, L., Korhonen, L., Lodén, M., Wirén, K., Grände, M., Skare, P., et al. (2015) · Acta Dermato Venereologica · doi:10.2340/00015555-2051 · Cited by 76 · see citing works

Efficacy of Urea Therapy in Children with Ichthyosis

Küster, W., Bohnsack, K., Rippke, F., et al. (1998) · Dermatology · doi:10.1159/000017902 · Cited by 73 · see citing works

Urea and retinoic acid in ichthyosis and their effect on transepidermal water loss and water holding capacity of stratum corneum

GRICE, K. A., Sattar, H., & Baker, H. (1973) · Acta Dermato Venereologica · doi:10.2340/0001555553114118 · Cited by 66 · see citing works

Moisturisers for the treatment of foot xerosis: a systematic review

Parker, J., Scharfbillig, R., & Jones, S. (2017) · Journal of Foot and Ankle Research · doi:10.1186/s13047-017-0190-9 · Cited by 58 · see citing works

Urea ointment in the nonsurgical avulsion of nail dystrophies.

Farber, E. M., & South, D. A. (1978) · PubMed · Cited by 55 · see citing works

Treatment with a Barrier-strengthening Moisturizer Prevents Relapse of Hand-eczema. An Open, Randomized, Prospective, Parallel Group Study

Lodén, M., Wirén, K., Smerud, K. T., Meland, N., Hønnås, H., Mørk, G., Lützow‐Holm, C., Funk, J., & Meding, B. (2010) · Acta Dermato Venereologica · doi:10.2340/00015555-0964 · Cited by 54 · see citing works

Successful Treatment with Topical N‐Acetylcysteine in Urea in Five Children with Congenital Lamellar Ichthyosis

Bassotti, A., Moreno, S., & Criado, E. (2011) · Pediatric Dermatology · doi:10.1111/j.1525-1470.2011.01375.x · Cited by 50 · see citing works

Treatment of scalp seborrheic dermatitis and psoriasis with an ointment of 40% urea and 1% bifonazole

Shemer, A., Nathansohn, N., Kaplan, B., et al. (2000) · International Journal of Dermatology · doi:10.1046/j.1365-4362.2000.00986-3.x · Cited by 45 · see citing works

Urea ointment in the nonsurgical avulsion of nail dystrophies--a reappraisal.

Da, S., & Farber, E. M. (1980) · PubMed · Cited by 44 · see citing works

The use of urea for the treatment of onychomycosis: a systematic review

Dars, S., Banwell, H. A., & Matricciani, L. (2019) · Journal of Foot and Ankle Research · doi:10.1186/s13047-019-0332-3 · Cited by 40 · see citing works

Efficacy and safety of hydrocortisone buteprate 0.1% cream in patients with atopic dermatitis

Sears, H. W., Bailer, J. W., & Yeadon, A. (1997) · Clinical Therapeutics · doi:10.1016/s0149-2918(97)80095-1 · Cited by 39 · see citing works

OUT-PATIENT TREATMENT OF ICHTHYOSIS: A DOUBLE-BLIND TRIAL OF OINTMENTS

Pope, F., Rees, J., Wells, R. S., et al. (1972) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1972.tb02231.x · Cited by 33 · see citing works

Urea: A Clinically Oriented Overview from Bench to Bedside.

Friedman, A., von Grote, E. C., & Meckfessel, M. (2016) · PubMed · Cited by 33 · see citing works

Comparison of linoleic acid-containing water-in-oil emulsion with urea-containing water-in-oil emulsion in the treatment of atopic dermatitis: a randomized clinical trial

Nasrollahi, S. A., Ayatollahi, A., Yazdanparast, T., Samadi, A., Hosseini, H., Shamsipour, M., Akhlaghi, A. A., Yadangi, S., Abels, C., & Firooz, A. (2018) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s145561 · Cited by 32 · see citing works

Non‐traumatic topical treatment of onychomycosis with urea associated with bifonazole

Torres‐Rodríguez, J. M., Madrenys, N., & Nicolás, M. (1991) · Mycoses · doi:10.1111/j.1439-0507.1991.tb00867.x · Cited by 30 · see citing works

10% urea cream (Laceran) for atopic dermatitis: A clinical and laboratory evaluation

Pigatto, P., Bigardi, A., Cannistraci, C., & Picardo, M. (1996) · Journal of Dermatological Treatment · doi:10.3109/09546639609086881 · Cited by 30 · see citing works

Cream or foam in pedal skin care: towards the ideal vehicle for urea used against dry skin

Borelli, C., Bielfeldt, S., Borelli, S., Schaller, M., & Körting, H. C. (2010) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2010.00576.x · Cited by 29 · see citing works

Treatment of onychomycosis: a randomized, double‐blind comparison study with topical bifonazole‐urea ointment alone and in combination with short‐duration oral griseofulvin

Friedman‐Birnbaum, R., Cohen, A., Shemer, A., et al. (1997) · International Journal of Dermatology · doi:10.1046/j.1365-4362.1997.00024.x · Cited by 29 · see citing works

Combination of fluconazole and urea in a nail lacquer for treating onychomycosis

Baran, R., & Coquard, F. (2005) · Journal of Dermatological Treatment · doi:10.1080/09546630510025950 · Cited by 29 · see citing works

Management of Toenail Onychomycosis with 2% Butenafine and 20% Urea Cream: A Placebo‐controlled, Double‐blind Study

Syed, T. A., Ahmadpour, O. A., Ahmad, S. A., et al. (1998) · The Journal of Dermatology · doi:10.1111/j.1346-8138.1998.tb02474.x · Cited by 26 · see citing works

Efficacy of topical 10% urea-based lotion in patients with ichthyosis vulgaris: a two-center, randomized, controlled, single-blind, right-vs.-left study in comparison with standard glycerol-based emollient cream

Tadini, G., Giustini, S., & Milani, M. (2011) · Current Medical Research and Opinion · doi:10.1185/03007995.2011.628381 · Cited by 26 · see citing works

Treatment of Onychomycosis by ODT Therapy with 20% Urea Ointment and 2% Tolnaftate Ointment

Ishii, M., Hamada, T., & Asai, Y. (2009) · Dermatologica · doi:10.1159/000249796 · Cited by 25 · see citing works

Usefulness of Lanoconazole (Astat®) cream in the treatment of hyperkeratotic type tinea pedis. Comparative study of monotherapy and combination therapy with 10% Urea Ointment (Pastaron®)

TANUMA, H., Tanuma, M., Abe, M., et al. (2001) · Mycoses · doi:10.1046/j.0933-7407.2001.00607.x · Cited by 22 · see citing works

Moisturizing treatment of patients with atopic dermatitis and ichthyosis vulgaris improves dry skin, but has a modest effect on gene expression regardless of FLG genotype

Hoppe, T., Winge, M. C. G., Bradley, M., et al. (2013) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12333 · Cited by 21 · see citing works

A practical approach to ichthyoses with systemic manifestations

Saral, S., Vural, A., Wollenberg, A., et al. (2016) · Clinical Genetics · doi:10.1111/cge.12828 · Cited by 21 · see citing works

A comparative evaluation of combination therapy of fluconazole 1% and urea 40% compared with fluconazole 1% alone in a nail lacquer for treatment of onychomycosis: therapeutic trial

Bassiri‐Jahromi, S., Ehsani, A. H., Mirshams‐Shahshahani, M., et al. (2011) · Journal of Dermatological Treatment · doi:10.3109/09546634.2011.588191 · Cited by 20 · see citing works

Chemical avulsion with urea nail lacquer

Baran, R., & Tosti, A. (2002) · Journal of Dermatological Treatment · doi:10.1080/09546630212345672 · Cited by 19 · see citing works

Butenafine hydrochloride (Mentax®) cream for the treatment of hyperkeratotic type tinea pedis and its transfer into the horny layer, with or without concomitant application of 20% urea ointment (Keratinamin®)

TANUMA, H., Doi, M., Ohta, Y., et al. (2001) · Mycoses · doi:10.1046/j.0933-7407.2001.00653.x · Cited by 19 · see citing works

Treatment of ichthyosis vulgaris with a urea-based emulsion: videodermatoscopy and confocal microscopy evaluation

Benintende, C., Boscaglia, S., Dinotta, F., et al. (2017) · Italian Journal of Dermatology and Venereology · doi:10.23736/s0392-0488.17.05743-1 · Cited by 16 · see citing works

Influence of Excipients on Moisturizing Effect of Urea

Couteau, C., Coiffard, L. J. M., & Sebille, V. (2006) · Drug Development and Industrial Pharmacy · doi:10.1080/03639040500466361 · Cited by 15 · see citing works

Treatment of hyperkeratosis with Kerafoam emollient foam (30% urea) to assess effectiveness and safety within a clinical setting: a case study report.

Goldstein, J. A., & Gurge, R. M. (2008) · PubMed · Cited by 11 · see citing works

Topical Treatment of Onychomycosis by Occlusive Dressing using Bifonazole Cream Containing 40% Urea.

Tsuboi, R., Unno, K., Komatsuzaki, H., et al. (1998) · Nippon Ishinkin Gakkai Zasshi · doi:10.3314/jjmm.39.11 · Cited by 11 · see citing works

Polyurethanes as New Excipients in Nail Therapeutics

Valdés, B. S. G., Serro, A. P., Marto, J. M., et al. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10040276 · Cited by 10 · see citing works

Acute periungueal dermatitis induced by application of urea-containing cream under occlusion

Piraccini, B. M., Alessandrini, A. M., Bruni, F., et al. (2012) · Journal of Dermatological Case Reports · doi:10.3315/jdcr.2012.1090 · Cited by 9 · see citing works

Topical Treatment with Urea-Hydrocortisone in Atopic Dermatitis

Laurberg, G. (2009) · Dermatologica · doi:10.1159/000251310 · Cited by 9 · see citing works

Einfluss eines ureahaltigen Lackes auf die Nagelqualität

Krüger, N., Reuther, T., Williams, S., et al. (2006) · Der Hautarzt · doi:10.1007/s00105-006-1215-7 · Cited by 8 · see citing works

Wirksamkeit auf das Symptom trockene Haut und Langzeitverträglichkeit von Laceran Lotion 10% Urea bei Patienten mit atopischem Ekzem

Bohnsack, K., Tausch, I., Gassmüller, J., et al. (1997) · H&G Zeitschrift für Hautkrankheiten · Cited by 8 · see citing works

Ultrasound assessment of the keratolytic effect of a 50% urea anhydrous paste on psoriasis plaques: a prospective study

Micali, G., Verzì, A. E., Musumeci, M. L., et al. (2019) · Giornale Italiano di Dermatologia e Venereologia · doi:10.23736/s0392-0488.19.06190-x · Cited by 7 · see citing works

Nail debridement after ablative fractional laser treatment and occlusive dressing with urea 20% cream: An alternative to nail extraction

Jung, Y. S., Lee, J. H., Kim, G. M., et al. (2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2017.04.008 · Cited by 5 · see citing works

Treatment of chronic plaque psoriasis with dithranol and urea creams: a double-blind study.

Mm, Y. (1982) · PubMed · Cited by 3 · see citing works

Einfluss eines ureahaltigen Lackes auf die Nagelqualität Evaluation mittels klinischer Scores und biophysikalischer Parameter

Krüger, N., Reuther, T., Williams, S., et al. (2006) · Der Hautarzt · Cited by 2 · see citing works

A Review of Moisturizers; History, Preparation, Characterization and Applications

Mawazi, S. M., Ann, J., Othman, N., Khan, J., Alolayan, S. O., Al thagfan, S. S., & Kaleemullah, M. (2022) · Cosmetics · doi:10.3390/cosmetics9030061 · Cited by 111 · see citing works

Keratosis pilaris: a common follicular hyperkeratosis.

Hwang, S., & Schwartz, R. A. (2008) · PubMed · Cited by 77 · see citing works

The Use of Silicones in Dermatology

LeVan, P., Sternberg, T. H., & Newcomer, V. D. (1957) · American Association of Industrial Nurses Journal · doi:10.1177/216507995700500406

IN VITRO SENSITIVITY OF DERMATOPHYTES TO UREA

Martins, J. E., Corim, S. M., Arriagada, G. L. H., et al. (2006) · Clinics · doi:10.1590/s1807-59322006000100003 · Cited by 3 · see citing works

Angioedema–Urticaria Due to Acitretin

Solak, B., Metin, N., & Erdem, M. T. (2014) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000000081 · Cited by 3 · see citing works

Dermatitis update: clinical manifestations, pathogenesis and current therapeutic approaches

Wedi, B. (2016) · Allergo Journal International · doi:10.1007/s40629-016-0133-1 · Cited by 2 · see citing works