The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
Going viral: chimeric antigen receptor T‐cell therapy for hematological malignancies
Abstract
Summary: On July 1, 2014, the United States Food and Drug Administration granted ‘breakthrough therapy’ designation to CTL 019, the anti‐CD 19 chimeric antigen receptor T‐cell therapy developed at the University of Pennsylvania. This is the first personalized cellular therapy for cancer to be so designated and occurred 25 years after the first publication describing genetic redirection of T cells to a surface antigen of choice. The peer‐reviewed literature currently contains the outcomes of more than 100 patients treated on clinical trials of anti‐CD 19 redirected T cells, and preliminary results on many more patients have been presented. At last count almost 30 clinical trials targeting CD 19 were actively recruiting patients in North America, Europe, and Asia. Patients with high‐risk B‐cell malignancies therefore represent the first beneficiaries of an exciting and potent new treatment modality that harnesses the power of the immune system as never before. A handful of trials are targeting non‐CD 19 hematological and solid malignancies and represent the vanguard of enormous preclinical efforts to develop CAR T‐cell therapy beyond B‐cell malignancies. In this review, we explain the concept of chimeric antigen receptor gene‐modified T cells, describe the extant results in hematologic malignancies, and share our outlook on where this modality is likely to head in the near future.
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Metadata
- Authors
- Gill, S., & June, C. H.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2014-12-15
- Volume
- 263
- Issue
- 1
- Pages
- 68-89
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2045720696
- Cited by
- 320
- References
- 169
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- closed
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