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Cited by 3,544Immune cells in cancerImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Coordinated regulation of myeloid cells by tumours

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Gabrilovich, Dmitry I., Ostrand-Rosenberg, Suzanne, Bronte, Vincenzo·2012·Nature Reviews Immunology
DOI 10.1038/nri3175PMC PMC3587148
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Abstract

Myeloid cells are the most abundant nucleated haematopoietic cells in the human body and are a collection of distinct cell populations with many diverse functions. The three groups of terminally differentiated myeloid cells - macrophages, dendritic cells and granulocytes - are essential for the normal function of both the innate and adaptive immune systems. Mounting evidence indicates that the tumour microenvironment alters myeloid cells and can convert them into potent immunosuppressive cells. Here, we consider myeloid cells as an intricately connected, complex, single system and we focus on how tumours manipulate the myeloid system to evade the host immune response.

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  • MDSCs suppress both innate and adaptive immunity within the tumor microenvironment via production of various immune suppressive molecules.

    “MDSCs suppress both innate and adaptive immunity within the tumor microenvironment via production of various immune suppressive molecules”

    From LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer (2018) · cites this paper as Gabrilovich et al., 2012

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Cited by

Sorted by citations

Authors
Gabrilovich, D. I., Ostrand-Rosenberg, S., & Bronte, V.
Affiliations
  • Moffitt Cancer Center (US)
  • University of Verona (IT)
Corresponding author
  • Gabrilovich, Dmitry I.
  • Bronte, Vincenzo
ORCID
Venue
Nature Reviews Immunology
Publisher
Springer Science and Business Media LLC
Published
2012-03-22
Volume
12
Issue
4
Pages
253-268
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
DOI
10.1038/nri3175
PMC
PMC3587148
OpenAlex
W2060672294
Cited by
3,544
References
16
Citations by year
2026: 110 · 2025: 173 · 2024: 231 · 2023: 241 · 2022: 318 · 2021: 295 · 2020: 308 · 2019: 259 · 2018: 242 · 2017: 269 · 2016: 312 · 2015: 275 · 2014: 255 · 2013: 200 · 2012: 54
FWCI
23.13
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (R01CA084488, R01CA141438, R01CA100062)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords
myeloid cells, tumor immunosuppression, tumor microenvironment, macrophages, dendritic cells, granulocytes, tumor immune evasion, myeloid differentiation, innate immunity, adaptive immunity
MeSH terms
Animals, Antineoplastic Agents, Humans, Immune Tolerance, Neoplasms, Myeloid Cells

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