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Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation
Abstract
Summary: The current review on the function of neutrophil cytosolic factor 1 (NCF1) and induced reactive oxygen species (ROS) is based on a genetic search for the major genes controlling autoimmune inflammatory disorders. Surprisingly, the disease‐promoting allele determined a lower ROS response and was therefore in complete contrast to the prevailing dogma. Once cloned, it opened the possibility to dissect this complex field from a new angle and with the possibilities to study the role of ROS in vivo. We found that NCF1 and NADPH oxidase 2 (NOX 2) complex‐derived ROS is an important regulator of several chronic inflammatory disorders by using models for rheumatoid arthritis, multiple sclerosis, psoriasis and psoriasis arthritis, gout, and lupus. ROS could therefore affect many different types of diseases and the common denominator seems to be that ROS regulate macrophages, which prevents inflammation from going chronic. The role of ROS is currently changing from being seen as toxic agents that will promote inflammation toward a more complex view with ROS as crucial regulators of immune and inflammatory pathways.
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“Phagocytes can release O2•− both into the phagosome and the extracellular space due to expression of NOX2 on both the phagosome and the plasma membrane [174].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [174]
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Self-citation
Metadata
- Authors
- Holmdahl, R., Sareila, O., Olsson, L. M., Bäckdahl, L., & Wing, K.
- Affiliations
- University of Turku (FI)
- Karolinska Institutet (SE)
- Corresponding author
- Holmdahl, Rikard
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2015-12-19
- Volume
- 269
- Issue
- 1
- Pages
- 228-247
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2200658189
- Cited by
- 131
- References
- 147
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 8 · 2023: 10 · 2022: 18 · 2021: 14 · 2020: 11 · 2019: 15 · 2018: 12 · 2017: 18 · 2016: 10 · 2015: 1
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Stiftelsen för Strategisk Forskning
- Knut och Alice Wallenbergs Stiftelse
- Seventh Framework Programme
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Keywords
- NCF1, NADPH oxidase 2, reactive oxygen species, rheumatoid arthritis, multiple sclerosis, psoriasis, psoriatic arthritis, gout, lupus, macrophages, genetic susceptibility
- MeSH terms
- NADPH Oxidase 2, Animals, Autoimmune Diseases, Humans, Inflammation, Membrane Glycoproteins, Oxidation-Reduction, Polymorphism, Genetic, Reactive Oxygen Species, NADPH Oxidases, Genetic Predisposition to Disease
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