Cited by 111T-cell and B-cell ImmunologyLymphatic System and DiseasesImmunotoxicology and immune responses

Fibroblastic reticular cells at the nexus of innate and adaptive immune responses

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Perez‐Shibayama, Christian, Gil‐Cruz, Cristina, Ludewig, Burkhard·2019·Immunological Reviews

Abstract

Summary: Lymphoid organs guarantee productive immune cell interactions through the establishment of distinct microenvironmental niches that are built by fibroblastic reticular cells (FRC). These specialized immune‐interacting fibroblasts coordinate the migration and positioning of lymphoid and myeloid cells in lymphoid organs and provide essential survival and differentiation factors during homeostasis and immune activation. In this review, we will outline the current knowledge on FRC functions in secondary lymphoid organs such as lymph nodes, spleen and Peyer's patches and will discuss how FRC s contribute to the regulation of immune processes in fat‐associated lymphoid clusters. Moreover, recent evidence indicates that FRC critically impact immune regulatory processes, for example, through cytokine deprivation during immune activation or through fostering the induction of regulatory T cells. Finally, we highlight how different FRC subsets integrate innate immunological signals and molecular cues from immune cells to fulfill their function as nexus between innate and adaptive immune responses.

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  • Structural cells (epithelium, endothelium, and fibroblasts) have been shown to contribute in important ways to mammalian immunity.

    “These three cell types, which we refer to as “structural cells”, have been shown to contribute in important ways to mammalian immunity7–11.”

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  1. [30]Gretz JE, Norbury CC, Anderson AO, Proudfoot AE, Shaw S. Lymph‐borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex. J Exp Med. 2000; 192(10): 1425‐ 1440. 11085745 PMC2193184

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Authors
Perez‐Shibayama, C., Gil‐Cruz, C., & Ludewig, B.
Affiliations
Kantonsspital St. Gallen (CH)
Corresponding author
Ludewig, Burkhard
Venue
Immunological Reviews
Publisher
Wiley
Published
2019-04-11
Volume
289
Issue
1
Pages
31-41
ISSN
  • 0105-2896 (ISSN-L)
  • 1600-065X
OpenAlex
W2938117765
Cited by
111
References
121
Citations by year
2026: 11 · 2025: 13 · 2024: 11 · 2023: 14 · 2022: 18 · 2021: 27 · 2020: 13 · 2019: 4
FWCI
1.34
Type
journal article
Language
en
Open access
Locations
  • Immunological Reviews (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (166500, 177208)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords
fibroblastic reticular cells, secondary lymphoid organs, lymph nodes, spleen, Peyer's patches, leukocyte migration, cytokine deprivation, regulatory T cells, innate-adaptive immune interaction, immune microenvironment
MeSH terms
Adipose Tissue, Animals, Fibroblasts, Homeostasis, Humans, Immunity, Innate, Lymphocyte Activation, Lymphoid Tissue, Stromal Cells, T-Lymphocytes, Regulatory, Adaptive Immunity, Immunomodulation

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