Fibroblastic reticular cells at the nexus of innate and adaptive immune responses
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Summary: Lymphoid organs guarantee productive immune cell interactions through the establishment of distinct microenvironmental niches that are built by fibroblastic reticular cells (FRC). These specialized immune‐interacting fibroblasts coordinate the migration and positioning of lymphoid and myeloid cells in lymphoid organs and provide essential survival and differentiation factors during homeostasis and immune activation. In this review, we will outline the current knowledge on FRC functions in secondary lymphoid organs such as lymph nodes, spleen and Peyer's patches and will discuss how FRC s contribute to the regulation of immune processes in fat‐associated lymphoid clusters. Moreover, recent evidence indicates that FRC critically impact immune regulatory processes, for example, through cytokine deprivation during immune activation or through fostering the induction of regulatory T cells. Finally, we highlight how different FRC subsets integrate innate immunological signals and molecular cues from immune cells to fulfill their function as nexus between innate and adaptive immune responses.
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Structural cells (epithelium, endothelium, and fibroblasts) have been shown to contribute in important ways to mammalian immunity.
“These three cell types, which we refer to as “structural cells”, have been shown to contribute in important ways to mammalian immunity7–11.”
From Structural cells are key regulators of organ-specific immune responses (2020) · cites this paper as [10]
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Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease
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Self-citation
- Authors
- Perez‐Shibayama, C., Gil‐Cruz, C., & Ludewig, B.
- Affiliations
- Kantonsspital St. Gallen (CH)
- Corresponding author
- Ludewig, Burkhard
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2019-04-11
- Volume
- 289
- Issue
- 1
- Pages
- 31-41
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- PMC
- PMC6850313
- OpenAlex
- W2938117765
- Cited by
- 111
- References
- 121
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 11 · 2023: 14 · 2022: 18 · 2021: 27 · 2020: 13 · 2019: 4
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Immunological Reviews (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (166500, 177208)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- fibroblastic reticular cells, secondary lymphoid organs, lymph nodes, spleen, Peyer's patches, leukocyte migration, cytokine deprivation, regulatory T cells, innate-adaptive immune interaction, immune microenvironment
- MeSH terms
- Adipose Tissue, Animals, Fibroblasts, Homeostasis, Humans, Immunity, Innate, Lymphocyte Activation, Lymphoid Tissue, Stromal Cells, T-Lymphocytes, Regulatory, Adaptive Immunity, Immunomodulation
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