A genetic correlation between age at pupation and melanization immune response of the yellow fever mosquito Aedes aegypti
Abstract
To investigate the evolutionary cost of an immune response, we selected six lines of the mosquito Aedes aegypti for earlier or later pupation and measured the extent to which this selection procedure changed the mosquito's ability to encapsulate and melanize a negatively charged Sephadex bead. After 10 generations of selection, the age at pupation in the two selection regimes differed by about 0.7 days, accompanied by an increase of wing length of the mosquitoes selected for late pupation. Among the mosquitoes that had been selected for early pupation, only 6% had strongly or completely melanized the bead, while among the individuals that had been selected for late pupation, 32% had melanized the bead. Thus, our results suggest a genetic correlation between age at pupation and immunocompetence. As a consequence, mosquitoes that respond to increased intense parasite pressure with more effective immunity are predicted to pay for the increased defense with slower development.
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Environmental variation contributes very largely to these life history and vectorial capacity traits.
“Because the relative contribution of environmental variation to these traits is very large (Koella and Boete, 2002; Lambrechts et al., 2006; Lehmann et al., 2006; Schwartz and Koella, 2002), independent comparisons of these traits in multiple settings will be valuable.”
From The molecular forms of Anopheles gambiae: a phenotypic perspective (2008) · cites this paper as Koella and Boete, 2002
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The molecular forms of Anopheles gambiae: a phenotypic perspective
Lehmann, T., & Diabate, A. (2008) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2008.06.003 · Cited by 177 · see citing works
“Because the rela contribution of environmental variation to these traits is very la (Koella and Boete, 2002; Lambrechts et al., 2006; Lehmann et 2006; Schwartz and Koella, 2002), independent comparison these traits in multiple settings will be valuable.”
- Authors
- Koella, J. C., & Boëte, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-05
- Volume
- 56
- Issue
- 5
- Pages
- 1074-1079
- ISSN
- 0014-3820 (ISSN-L)
- 1558-5646
- OpenAlex
- W2177942131
- Cited by
- 97
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 8 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 7 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 6 · 2012: 2
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Evolution (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Keywords
- Aedes aegypti, melanization, encapsulation, genetic correlation, immunocompetence, developmental rate, wing length, selection lines
- MeSH terms
- Aedes, Animals, Body Constitution, Pupa, Selection, Genetic, Yellow Fever
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