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Cited by 63Garlic and Onion StudiesCell Adhesion Molecules ResearchChemokine receptors and signaling

Allicin inhibits SDF-1α-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression

Sela, Uri, Ganor, Sharon, Hecht, Iris, Brill, Alexander, Miron, Talia, Rabinkov, Aharon, Wilchek, Meir, Mirelman, David +2 more·2004·Immunology
DOI 10.1111/j.0019-2805.2004.01841.x
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Abstract

Summary: Allicin, a major ingredient of fresh garlic extract that is produced during the crushing of garlic cloves, exerts various beneficial biological effects, including a broad spectrum of antimicrobial activity, antihyperlipidaemic and antihypertensive effects. However, how allicin affects the immune system is less well known, and its effect on human T cells has never been studied. Here, we examined the in‐vitro effects of allicin on the functioning of T cells related to their entry to inflamed extravascular sites. We found that allicin (20–100 µ m) inhibits the SDF‐1α (CXCL12)‐induced T cell migration through fibronectin (FN), and that this inhibition is mediated by the down‐regulation of (i) the reorganization of cortical actin and the subsequent T cell polarization, and (ii) T cell adhesion to FN. Moreover, allicin also inhibited T cell adhesion to endothelial cells and transendothelial migration. The mechanisms underlying these inhibitory effects of allicin are associated with its ability to down‐regulate the phosphorylation of Pyk2, an intracellular member of the focal adhesion kinases, and to reduce the expression of the VCAM‐1‐ and FN‐specific α4β1‐integrin (VLA‐4). The ability of allicin to down‐regulate these chemokine‐induced and VLA‐4‐mediated T cell functions explains its beneficial biological effects in processes where T cells play an important role and suggests that allicin may be used therapeutically with chronic inflammatory diseases.

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Crossref · 10.1111/j.0019-2805.2004.01841.x

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  • Allicin works on T-cell lymphocytes by inhibiting the SDF1α chemokine associated with weakness of the dynamic structure of the actin cytoskeleton, and it leads to inhibition of transendothelial migration of neutrophils.

    “Moreover, allicin works on T-cell lymphocytes by inhibiting the SDF1α chemokine which is associated with the weakness of the dynamic structure of the actin cytoskeleton [75], in addition to this, it leads to inhibit the Transendothelial migration of neutrophils.”

    From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [75]

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Authors
Sela, U., Ganor, S., Hecht, I., Brill, A., Miron, T., Rabinkov, A., Wilchek, M., Mirelman, D., Lider, O., & Hershkoviz, R.
Affiliations
  • Assaf Harofeh Medical Center (IL)
  • Weizmann Institute of Science (IL)
Corresponding author
Sela, Uri
ORCID
Venue
Immunology
Publisher
Wiley
Published
2004-03-30
Volume
111
Issue
4
Pages
391-399
ISSN
  • 0019-2805 (ISSN-L)
  • 1365-2567
DOI
10.1111/j.0019-2805.2004.01841.x
OpenAlex
W2081449047
Cited by
63
References
43
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 8 · 2021: 7 · 2020: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 2
FWCI
3.52
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Keywords
allicin, garlic, SDF-1α, CXCL12, T cell migration, fibronectin, endothelial cells, focal adhesion kinase, VLA-4, alpha4beta1 integrin, VCAM-1, T cell adhesion, transendothelial migration, T cell polarization, chronic inflammation
MeSH terms
Actins, Cell Adhesion, Chemotaxis, Leukocyte, Cytoskeleton, Disulfides, Endothelium, Vascular, Fibronectins, Humans, Phosphorylation, Protein-Tyrosine Kinases, Sulfinic Acids, T-Lymphocytes, Down-Regulation, Chemokines, CXC, Integrin alpha4beta1, Macromolecular Substances, Focal Adhesion Kinase 2, Chemokine CXCL12

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