Cited by 309Dermatology and Skin DiseasesSphingolipid Metabolism and SignalingAdvancements in Transdermal Drug Delivery

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Impaired Sphingomyelinase Activity and Epidermal Differentiation in Atopic Dermatitis

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Jensen, Jens-Michael, Fölster-Holst, Regina, Baranowsky, Anke, Schunck, Michael, Winoto-Morbach, Supandi, Neumann, Claudia, Schütze, Stefan, Proksch, Ehrhardt·2004·Journal of Investigative Dermatology

DOI 10.1111/j.0022-202x.2004.22621.x

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Abstract

A defective permeability barrier leads to the penetration of environmental allergens into the skin and initiates immunological reactions and inflammation crucially involved in the pathogenesis of atopic dermatitis (AD). Decreased stratum corneum ceramide content may cause the defect in permeability barrier function consistently found in AD. Acid and neutral sphingomyelinase (A- and N-SMase) generate ceramides with structural and signal transduction functions in epidermal proliferation and differentiation. We determined epidermal SMase activities, DNA synthesis, involucrin, loricrin, filaggrin, and keratin expression in lesional and non-lesional skin of AD patients. We found decreased epidermal A-SMase activity in lesional and non-lesional skin, correlating with reduced stratum corneum ceramide content and disturbed barrier function. N-SMase activity was reduced in non-lesional skin and more significantly reduced in lesional skin, correlating with impaired expression of cornified envelope proteins and keratins, important for skin barrier function. Changes in involucrin, loricrin, filaggrin, keratin K 5 (basal) and K 16 (proliferation associated) were noticed in non-lesional and lesional skin, whereas changes in K 10 (suprabasal), K 6 (proliferation associated), and K 17 (inflammation associated) were found only in lesional skin. In summary, reduction in SMase-generating ceramides and impaired differentiation are involved in the defective barrier function found in AD.

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Diagnostic features of atopic dermatitis
Hanifin, J. M., & Rajka, G. (1980) · Acta Dermato-Venereologica · doi:10.2340/00015555924447 · Cited by 5,086
Guidelines for transepidermal water loss (TEWL) measurement: A Report from the Standardization Group of the European Society of Contact Dermatitis
Pinnagoda, J., Tupkek, R. A., Agner, T., & Serup, J. (1990) · Contact Dermatitis · doi:10.1111/j.1600-0536.1990.tb01553.x · Cited by 1,092
Changes in keratin gene expression during terminal differentiation of the keratinocyte
Fuchs, E. V., & Green, H. (1980) · Cell · doi:10.1016/0092-8674(80)90094-x · Cited by 1,085
Decreased Level of Ceramides in Stratum Corneum of Atopic Dermatitis: An Etiologic Factor in Atopic Dry Skin?
Imokawa, G., Abe, A., Jin, K., Higaki, Y., Kawashima, M., & Hidano, A. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12470233 · Cited by 1,040
Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling
Wiegmann, K., Schütze, S., Machleidt, T., Witte, D., & Krönke, M. (1994) · Cell · doi:10.1016/0092-8674(94)90275-5 · Cited by 714
Self-citation
Structural and Lipid Biochemical Correlates of the Epidermal Permeability Barrier
Elias, P. M., & Menon, G. K. (1991) · Advances in lipid research · doi:10.1016/b978-0-12-024924-4.50005-5 · Cited by 677
Ceramide and cholesterol composition of the skin of patients with atopic dermatitis
Nardo, A. D. (1998) · Acta Dermato Venereologica · doi:10.1080/00015559850135788 · Cited by 483
Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice.
Wood, L. C., Jackson, S. M., Elias, P. M., Grünfeld, C., & Feingold, K. R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115884 · Cited by 454
Identification of a major keratinocyte cell envelope protein, loricrin
Mehrel, T., Hohl, D., Rothnagel, J. A., Longley, M. A., Bundman, D. S., Cheng, C., Lichti, U. F., Bisher, M. E., Steven, A. C., Steinert, P. M., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90073-n · Cited by 436

Show all 83 references

Research works printed but not linked: 2

Barth, 1989, Skin surface lipids in atopic eczema and ichthyosis, Chron Derm, 10, 609
Jakobza, 1981, Surface skin lipids in atopic dermatitis, Dermatol Monatsschr, 167, 26

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Authors: Jensen, J.-M., Fölster-Holst, R., Baranowsky, A., Schunck, M., Winoto-Morbach, S., Neumann, C., Schütze, S., & Proksch, E.
Affiliations: Christian-Albrechts-Universität zu Kiel (DE)
Corresponding author: Proksch, Ehrhardt
ORCID: Baranowsky, Anke
Proksch, Ehrhardt
Venue: Journal of Investigative Dermatology
Publisher: Elsevier BV
Published: 2004-06
Volume: 122
Issue: 6
Pages: 1423-1431
ISSN: 0022-202X (ISSN-L)
DOI: 10.1111/j.0022-202x.2004.22621.x
OpenAlex: W2077796802
Cited by: 309
References: 83
Citations by year: 2026: 1 · 2025: 1 · 2024: 13 · 2023: 12 · 2022: 13 · 2021: 16 · 2020: 18 · 2019: 12 · 2018: 11 · 2017: 16 · 2016: 15 · 2015: 13 · 2014: 23 · 2013: 19 · 2012: 24
FWCI: 15.28
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4201 d)
Locations: Journal of Investigative Dermatology (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft (SFB 415)
Topics: Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Keywords: atopic dermatitis, sphingomyelinase, acid sphingomyelinase, neutral sphingomyelinase, ceramide, stratum corneum, skin barrier function, epidermal differentiation, involucrin, loricrin, filaggrin, keratin, DNA synthesis, lesional skin
MeSH terms: Filaggrin Proteins, Cell Differentiation, Cell Division, Ceramides, Dermatitis, Atopic, Epidermis, Female, Humans, Intermediate Filament Proteins, Keratins, Male, Membrane Proteins, Protein Precursors, Sphingomyelin Phosphodiesterase, Substrate Specificity, Water, Blotting, Western, Signal Transduction, Biomarkers

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Impaired Sphingomyelinase Activity and Epidermal Differentiation in Atopic Dermatitis

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