The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Use of CpG oligodeoxynucleotides as immune adjuvants
Abstract
Summary: Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the production of T helper 1 (Th1) and pro‐inflammatory cytokines and the maturation/activation of professional antigen‐presenting cells. These activities enable CpG ODNs to act as immune adjuvants, accelerating and boosting antigen‐specific immune responses by 5–500‐fold. These effects are optimized by maintaining close physical contact between the CpG DNA and the immunogen. Animal challenge models establish that protective immunity can be accelerated and magnified by coadministering CpG DNA with vaccines. Ongoing clinical studies indicate that CpG ODNs are safe and well tolerated when administered as adjuvants to humans, and in some cases, they increase vaccine‐induced immune responses.
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Cites
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 19×
“Cells lacking TLR9 do not respond to CpG DNA but can be made responsive by transfection with gene constructs encoding that receptor (17, 18).”
BackgroundInfluentialDirect Gene Transfer into Mouse Muscle in Vivo
Wolff, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., & Felgner, P. L. (1990) · Science · doi:10.1126/science.1690918 · Cited by 4,173
CpG motifs in bacterial DNA trigger direct B-cell activation
Krieg, A. M., Yi, A.-K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A., & Klinman, D. M. (1995) · Nature · doi:10.1038/374546a0 · Cited by 3,508
Self-citationInnate Immunity: The Virtues of a Nonclonal System of Recognition
Medzhitov, R., & Janeway, C. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80412-2 · Cited by 2,434
Kadowaki, N., Ho, S., Antonenko, S., de Waal Malefyt, R., Kastelein, R. A., Bazan, F., & Liu, Y.-J. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.863 · Cited by 1,964
Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells
Hartmann, G., & Krieg, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.944 · Cited by 605
Contribution of CpG motifs to the immunogenicity of DNA vaccines
Klinman, D. M., Yamshchikov, G., & Ishigatsubo, Y. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.8.3635 · Cited by 507
Self-citation
Cited by
Streit (2005) · doi:10.1179/016164105x49463 · Cited by 100
Intracellular PRRs Activation in Targeting the Immune Response Against Fungal Infections
Jannuzzi, G. P., de Almeida, J. R. F., Paulo, L. N. M., de Almeida, S. R., & Ferreira, K. S. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.591970 · Cited by 29
Metadata
- Authors
- Klinman, D. M., Currie, D., Gursel, I., & Verthelyi, D.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2004-05-05
- Volume
- 199
- Issue
- 1
- Pages
- 201-216
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2049483717
- Cited by
- 306
- References
- 7
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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