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Cited by 73T-cell and B-cell ImmunologyRheumatoid Arthritis Research and TherapiesPsoriasis: Treatment and Pathogenesis

CD28nullCD4+ T Cells – Characterization of an Effector Memory T‐Cell Population in Patients with Rheumatoid Arthritis

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Fasth, A. E. R., Cao, D., Van Vollenhoven, R., Trollmo, C., Malmström, V.·2004·Scandinavian Journal of Immunology
DOI 10.1111/j.0300-9475.2004.01464.x
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Abstract

Abstract.: CD4+ T cells lacking the costimulatory molecule CD28 have been described both in elderly individuals and in chronic inflammatory disorders, one being rheumatoid arthritis (RA). We, in this study, provide a comprehensive characterization of cell surface markers on and function of such CD28 null CD4+ T cells, as well as correlations with clinical parameters. We conclude that of all surface markers associated with these cells, only CD57 and CD11b are expressed on the majority of them. This CD28 null population occurred in one‐third of patients with RA and was independent of clinical characteristics. The population was persistent and expanded in peripheral blood, but was excluded from the joint in most patients. Functionally, CD28 null CD4+ T cells were potent effector memory cells with regard to their proliferation and cytokine‐secretion profiles. This capacity correlated with a hitherto unpublished surface phenotype, the cells being uniformly CCR7– and CD43 high. Moreover, a new terminally differentiated CD45RA+CCR7– population of CD4+ T cells was identified. We would like to suggest that in the unbalanced immune system of patients with autoimmune disease and chronic infection an expanded CD28 null CD4+ T‐cell population able to secrete high levels of cytokines is likely to contribute to disease manifestations.

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  • CD28-negative effector memory CD4+ T-cells have been reported in humans only in association with autoimmune diseases such as rheumatoid arthritis, Crohn's disease or multiple sclerosis.

    “Effector memory CD4 + T-cells lacking CD28 expression have been reported in humans, but only in association with autoimmune diseases such as rheumatoid arthritis, Crohn's disease or multiple sclerosis (Markovic-Plese et al., 2001;Fasth et al., 2004;Garcia de Tena et al., 2004), and were not observed with the healthy donors used in this study.”

    From Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4 <sup>+</sup> effector memory T‐cells (2010) · cites this paper as Fasth et al., 2004

    The Introduction (page not specified) says CD28-negative CD4+ T cells have been described in healthy elderly adults as well as patients with inflammatory conditions. The paper studies these cells as an effector-memory population in rheumatoid arthritis, but it does not support—and its Introduction contradicts—the claim that they have been reported only in association with autoimmune disease. (LLM, conf=0.88)

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Authors
Fasth, A. E. R., Cao, D., Van Vollenhoven, R., Trollmo, C., & Malmström, V.
Affiliations
Karolinska University Hospital (SE)
Corresponding author
Malmström, V.
ORCID
Malmström, V.
Venue
Scandinavian Journal of Immunology
Publisher
Wiley
Published
2004-07-05
Volume
60
Issue
1-2
Pages
199-208
ISSN
  • 0300-9475 (ISSN-L)
  • 1365-3083
DOI
10.1111/j.0300-9475.2004.01464.x
OpenAlex
W2041475712
Cited by
73
References
3
Citations by year
2025: 3 · 2024: 2 · 2023: 1 · 2022: 3 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 7 · 2014: 8 · 2013: 4 · 2012: 4
FWCI
1.56
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Scandinavian Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Sveriges Läkarförbund
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
rheumatoid arthritis, effector memory T cells, CD57, CD11b, CCR7, CD43, CD45RA, T-cell markers, T cell proliferation, cytokine production, autoimmune disease, chronic inflammation, T cell differentiation
MeSH terms
Adult, Aged, Arthritis, Rheumatoid, Female, Flow Cytometry, HLA-DR Antigens, Humans, Immunologic Memory, Male, Middle Aged, Receptors, Antigen, T-Cell, CD4-Positive T-Lymphocytes, Immunophenotyping, T-Lymphocyte Subsets, CD28 Antigens

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