CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity.
Open accessAbstract
Clonal expansion of CD4+ T cells is a characteristic finding in patients with RA and is only infrequently found in patients with psoriatic arthritis and healthy controls. Expanded CD4+ clonotypes are present in the blood, infiltrate into the joint, and persist over years. We have not addressed the question of whether the expanded clonotypes have unique functional and phenotypic properties which may explain the preferential in vivo expansion in RA. In contrast to most CD4+ T cells, expanded clonotypes lacked the expression of the CD28 and CD7 cell surface molecules. Accordingly, the subsets of CD4+ CD28- (9.7 vs 1.7, P = 0.00002) and CD4+ CD7- T cells (21.5 vs 12.26, P = 0.018) were increased in RA patients compared with age-matched normal individuals. Despite the lack of CD28 expression, clonally expanded CD4+ T cells were not anergic but proliferated in response to immobilized anti-CD3 and could be maintained in tissue culture. In vivo expanded CD4+ T cells were autoreactive to ubiquitously distributed autoantigens. They responded in an autologous mixed lymphocyte reaction, and T cell clones isolated from selected patients proliferated to autologous peripheral blood adherent cells. These data suggest that in RA patients selected CD4+ T cells which share the CD7- CD28- phenotype escape from peripheral tolerance.
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Cites
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
Watanabe‐Fukunaga, R., Brannan, C., Copeland, N., Jenkins, N., & Nagata, S. (1992) · Nature · doi:10.1038/356314a0 · Cited by 3,153 · see citing works
Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
Dhein, J., Walczak, H., Bäumler, C., Debatin, K., & Krammer, P. (1995) · Nature · doi:10.1038/373438a0 · Cited by 1,814 · see citing works
Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
Ju, S., Panka, D., Cui, H., Ettinger, R., EI-Khatib, M., Sherr, D., Stanger, B., & Marshak-Rothstein, A. (1995) · Nature · doi:10.1038/373444a0 · Cited by 1,709 · see citing works
Epstein, F. H., & Harris, E. D. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005033221805 · Cited by 1,542 · see citing works
Brunner, T., Mogil, R. J., LaFace, D., Yoo, N. J., Mahboubi, A., Echeverri, F., Martin, S. J., Force, W. R., Lynch, D. H., Ware, C. F., et al. (1995) · Nature · doi:10.1038/373441a0 · Cited by 1,314 · see citing works
The Role of the CD28 Receptor During T Cell Responses to Antigen
Linsley, P. S., & Ledbetter, J. A. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.001203 · Cited by 1,298 · see citing works
Moskophidis, D., Lechner, F., Pircher, H., & Zinkernagel, R. M. (1993) · Nature · doi:10.1038/362758a0 · Cited by 1,240 · see citing works
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL
Boise, L., Minn, A. J., Noel, P. J., June, C. H., Accavitti, M. A., Lindsten, T., & Thompson, C. B. (1995) · Immunity · doi:10.1016/1074-7613(95)90161-2 · Cited by 1,210 · see citing works
Apoptosis And Programmed Cell Death In Immunity
Cohen, J., Duke, R. C., Fadok, V. A., & Sellins, K. S. (1992) · Annual Review of Immunology · doi:10.1146/annurev.iy.10.040192.001411 · Cited by 1,112 · see citing works
Lantz, O. J., & Bendelac, A. S. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.3.1097 · Cited by 1,036 · see citing works
Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.
Choi, Y., Kotzin, B. L., Herron, L. R., Callahan, J. E., Marrack, P., & Kappler, J. W. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.8941 · Cited by 954 · see citing works
Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity
Webb, S. R., Morris, C., & Sprent, J. (1990) · Cell · doi:10.1016/0092-8674(90)90420-j · Cited by 885 · see citing works
Posnett, D. N., Sinha, R., Kabak, S., & Russo, C. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.2.609 · Cited by 761 · see citing works
Singer, G. G., & Abbas, A. K. (1994) · Immunity · doi:10.1016/1074-7613(94)90067-1 · Cited by 697 · see citing works
A Subset of CD4 + Thymocytes Selected by MHC Class I Molecules
Bendelac, A. S., Killeen, N. P., Littman, D. R., & Schwartz, R. H. (1994) · Science · doi:10.1126/science.7907820 · Cited by 460 · see citing works
CD28- T lymphocytes. Antigenic and functional properties
Azuma, M., Phillips, J. H., & Lanier, L. L. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.4.1147 · Cited by 392 · see citing works
Predominantly T-Cell Infiltrate in Rheumatoid Synovial Membranes
van Boxel, J. A., & Paget, S. A. (1975) · New England Journal of Medicine · doi:10.1056/nejm197509112931101 · Cited by 387 · see citing works
Interconversion of CD45R subsets of CD4 T cells in vivo
Bell, E. B., & Sparshott, S. M. (1990) · Nature · doi:10.1038/348163a0 · Cited by 357 · see citing works
Akbar, A. N., Borthwick, N., Salmon, M., Gombert, W. M., Bofill, M., Shamsadeen, N., Pilling, D., Pett, S. L., Grundy, J. E., & Janossy, G. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.2.427 · Cited by 336 · see citing works
Phenotypic Characterization of Cutaneous T-Cell Lymphoma
Haynes, B. F., Metzgar, R. S., Minna, J. D., & Bunn, P. A. (1981) · New England Journal of Medicine · doi:10.1056/nejm198105283042202 · Cited by 334 · see citing works
The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster
Lynch, D. H., Watson, M. L., Alderson, M. R., Baum, P. R., Miller, R. E., Tough, T. W., Gibson, M., Davis-Smyth, T., Smiths, C. A., Hunter, K. W., et al. (1994) · Immunity · doi:10.1016/1074-7613(94)90106-6 · Cited by 331 · see citing works
Genomic Amplification with Transcript Sequencing
Stoflet, E. S., Koeberl, D. D., Sarkar, G., & Sommer, S. S. (1988) · Science · doi:10.1126/science.3340835 · Cited by 320 · see citing works
Ramsdell, F., Seaman, M. S., Miller, R. E., Picha, K. S., Kennedy, M. K., & Lynch, D. H. (1994) · International Immunology · doi:10.1093/intimm/6.10.1545 · Cited by 311 · see citing works
Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects.
Hingorani, R., Choi, I., Akolkar, P. N., Gulwani-Akolkar, B., Pergolizzi, R. G., Silver, J., & Gregersen, P. K. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.10.5762 · Cited by 282 · see citing works
WALDENSTRÖM, J. G. (1984) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1984.tb05032.x · Cited by 248 · see citing works
Weyand, C. M., Xie, C., & Goronzy, J. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115814 · Cited by 230 · see citing works
Self-citationMolecules involved in T-cell costimulation
Jenkins, M. K., & Johnson, J. G. (1993) · Current Opinion in Immunology · doi:10.1016/0952-7915(93)90054-v · Cited by 229 · see citing works
Fitzgerald, J. E., Ricalton, N. S., Meyer, A. C., West, S., Kaplan, H. J., Behrendt, C. E., & Kotzin, B. L. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.7.3538 · Cited by 203 · see citing works
HLA heterozygosity contributes to susceptibility to rheumatoid arthritis
Wordsworth, P., Pile, K., Buckely, J. D., Lanchbury, J. S. S., Ollier, W., Lathrop, M. G., & Bell, J. (2001) · CRC Press eBooks · doi:10.3109/9780203214237-44 · Cited by 189 · see citing works
Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice.
Jevnikar, A. M., Grusby, M. J., & Glimcher, L. H. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1137 · Cited by 189 · see citing works
Cyclic regulation of CD45 isoform expression in a long term human CD4+CD45RA+ T cell line
Rothstein, D. M., Yamada, A., Schlossman, S. F., & Morimoto, C. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.4.1175 · Cited by 182 · see citing works
Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis.
Goronzy, J. J., Bartz‐Bazzanella, P., Hu, W. T., Jendro, M. C., Walser-Kuntz, D. R., & Weyand, C. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117561 · Cited by 156 · see citing works
Self-citationOligoclonal CD8+ T cells are preferentially expanded in the CD57+ subset.
Morley, J. K., Batliwalla, F., Hingorani, R., & Gregersen, P. K. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.11.6182 · Cited by 155 · see citing works
Oligoclonal T cell proliferation in patients with rheumatoid arthritis and their unaffected siblings
Waase, I., Kayser, C., Carlson, P. J., Goronzy, J. J., & Weyand, C. M. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780390606 · Cited by 135 · see citing works
Self-citationClonal V alpha 12.1+ T cell expansions in the peripheral blood of rheumatoid arthritis patients.
Dersimonian, H., Sugita, M., Glass, D. N., Maier, A. L., Weinblatt, M. E., Reme, T. X., & Brenner, M. B. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.6.1623 · Cited by 119 · see citing works
CD7- T cells represent a subset of normal human blood lymphocytes
Reinhold, U., Abken, H., Kukel, S., Moll†, M., Müller, R. H., Oltermann, I., & Kreysel, H. W. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.5.2081 · Cited by 104 · see citing works
Legac, É., Autran, B., Merle‐Béral, H., Katlama, C., & Debré, P. (1992) · Blood · doi:10.1182/blood.v79.7.1746.1746 · Cited by 90 · see citing works
A Th0/Th2-like function of CD4+CD7- T helper cells from normal donors and HIV-infected patients.
Autran, B., Legac, É., Blanc, C., & Debré, P. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.3.1408 · Cited by 88 · see citing works
CD7-Negative Helper T Cells Accumulate in Inflammatory Skin Lesions
Moll, M., Reinhold, U., Kukel, S., Abken, H., Müller, R. H., Oltermann, I., & Kreysel, H. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12371791 · Cited by 78 · see citing works
Mechanisms underlying the formation of the T cell receptor repertoire in rheumatoid arthritis
Walser-Kuntz, D. R., Weyand, C. M., Weaver, A. J., O’Fallon, W. M., & Goronzy, J. J. (1995) · Immunity · doi:10.1016/1074-7613(95)90004-7 · Cited by 67 · see citing works
Self-citationA distinct subset of human CD4+ cells with a limited alloreactive T cell receptor repertoire.
Morishita, Y., Sao, H., Hansen, J. A., & Martin, P. J. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.9.2783 · Cited by 48 · see citing works
CD7– T cells in rheumatoid arthritis
Lazarovits, A. I., White, M. J., & Karsh, J. (1992) · Arthritis & Rheumatism · doi:10.1002/art.1780350604 · Cited by 30 · see citing works
Flagged first, then by citations
1 of the 43 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Brenchley, J. M., Karandikar, N. J., Betts, M. R., Ambrozak, D. R., Hill, B. J., Crotty, L. E., Casazza, J. P., Kuruppu, J., Migueles, S. A., Connors, M., et al. (2003) · Blood · doi:10.1182/blood-2002-07-2103 · Cited by 1,073 · see citing works
Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis
Lin, Y., Anzaghe, M., & Schülke, S. (2020) · Cells · doi:10.3390/cells9040880 · Cited by 967 · see citing works
Organ-specific disease provoked by systemic autoimmunity.
Kouskoff, V., Korganow, A., Duchatelle, V., Degott, C., Benoist, C., & Mathis, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81989-3 · Cited by 949 · see citing works
The immunology of rheumatoid arthritis
Weyand, C. M., & Goronzy, J. J. (2020) · Nature Immunology · doi:10.1038/s41590-020-00816-x · Cited by 821 · see citing works
Self-citationCD28− T cells: their role in the age-associated decline of immune function
Weng, N., Akbar, A. N., & Goronzy, J. J. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.03.013 · Cited by 629 · see citing works
Self-citationSpatial map of human T cell compartmentalization and maintenance over decades of life
Thome, J. J. C., Yudanin, N., Ohmura, Y., Kubota, M., Grinshpun, B., Sathaliyawala, T., Kato, T., Lerner, H., Shen, Y., & Farber, D. L. (2014) · Cell · doi:10.1016/j.cell.2014.10.026 · Cited by 587 · see citing works
Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes.
Liuzzo, G., Goronzy, J. J., Yang, H., Kopecky, S. L., Holmes, D. R., Frye, R. L., & Weyand, C. M. (2000) · Circulation · doi:10.1161/01.cir.101.25.2883 · Cited by 552 · see citing works
Self-citationAging of the Immune System. Mechanisms and Therapeutic Targets
Weyand, C. M., & Goronzy, J. J. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201602-095aw · Cited by 554 · see citing works
Self-citationGroh, V., Brühl, A., El-Gabalawy, H. S., Nelson, J. L., & Spies, T. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1632807100 · Cited by 507 · see citing works
T cell subset-specific susceptibility to aging
Czesnikiewicz-Guzik, M., Lee, W.-W., Cui, D., Hiruma, Y., Lamar, D. L., Yang, Z.-Z., Ouslander, J. G., Weyand, C. M., & Goronzy, J. J. (2008) · Clinical Immunology · doi:10.1016/j.clim.2007.12.002 · Cited by 478 · see citing works
Self-citationT cell homeostasis in patients with rheumatoid arthritis
Koetz, K., Bryl, E., Spickschen, K., O’Fallon, W. M., Goronzy, J. J., & Weyand, C. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.9203 · Cited by 467 · see citing works
Self-citationCD28 extinction in human T cells: altered functions and the program of T‐cell senescence
Vallejo, A. N. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00256.x · Cited by 432 · see citing works
Perturbation of the T-cell repertoire in patients with unstable angina.
Liuzzo, G., Kopecky, S. L., Frye, R. L., Fallon, W. M. O., Maseri, A., Goronzy, J. J., & Weyand, C. M. (1999) · Circulation · doi:10.1161/01.cir.100.21.2135 · Cited by 398 · see citing works
Self-citationPI3Kδ and PI3Kγ: partners in crime in inflammation in rheumatoid arthritis and beyond?
Rommel, C., Camps, M., & Ji, H. (2007) · Nature reviews. Immunology · doi:10.1038/nri2036 · Cited by 403 · see citing works
Pasceri, V., & Yeh, E. T. H. (1999) · Circulation · doi:10.1161/01.cir.100.21.2124 · Cited by 381 · see citing works
Inflammaging decreases adaptive and innate immune responses in mice and humans
Frasca, D., & Blomberg, B. B. (2016) · Biogerontology · doi:10.1007/s10522-015-9578-8 · Cited by 357 · see citing works
van Leeuwen, E. M. M., Remmerswaal, E. B. M., Vossen, M. T. M., Rowshani, A. T., Dillen, P. M. E. W., van Lier, R. A. W., & ten Berge, I. J. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1834 · Cited by 369 · see citing works
T cells and aging january 2002 update
Pawelec, G. (2002) · Frontiers in bioscience · doi:10.2741/a831 · Cited by 368 · see citing works
Pawelec, G. (1998) · Frontiers in bioscience · doi:10.2741/a266 · Cited by 357 · see citing works
Yang, Z., Fujii, H., Mohan, S. V., Goronzy, J. J., & Weyand, C. M. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130252 · Cited by 334 · see citing works
Self-citationReplicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?
Effros, R. B., & Pawelec, G. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01079-7 · Cited by 336 · see citing works
Yen, J., Moore, B. E., Nakajima, T. E., Scholl, D., Schaid, D. J., Weyand, C. M., & Goronzy, J. J. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.10.1159 · Cited by 335 · see citing works
Self-citationFunctional Study of CD4+CD25+ Regulatory T Cells in Health and Autoimmune Hepatitis
Longhi, M. S., Hussain, M. J., Mitry, R. R., Arora, S. K., Mieli‐Vergani, G., Vergani, D., & Ma, Y. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4484 · Cited by 323 · see citing works
Goronzy, J. J., & Weyand, C. M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0970-0 · Cited by 292 · see citing works
Self-citationExpansion of unusual CD4+ T cells in severe rheumatoid arthritis
Martens, P. B., Goronzy, J. J., Schaid, D. J., & Weyand, C. M. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400615 · Cited by 290 · see citing works
Self-citationRuchatz, H., Leung, B. P. L., Wei, X., McInnes, I. B., & Liew, F. Y. (1998) · PubMed · Cited by 290 · see citing works
The role of T cells in the immunopathogenesis of rheumatoid arthritis. New perspectives
Fox, D. A. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400403 · Cited by 289 · see citing works
Perturbation of the T cell repertoire in rheumatoid arthritis
Wagner, U. G., Koetz, K., Weyand, C. M., & Goronzy, J. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14447 · Cited by 278 · see citing works
Self-citationDown-Regulation of CD28 Expression by TNF-α
Bryl, E., Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3231 · Cited by 264 · see citing works
Self-citationInflammation: A pivotal link between autoimmune diseases and atherosclerosis
Abou‐Raya, A., & Abou‐Raya, S. (2006) · Autoimmunity Reviews · doi:10.1016/j.autrev.2005.12.006 · Cited by 264 · see citing works
Recent Advances in Understanding the Pathogenesis of Rheumatoid Arthritis: New Treatment Strategies
Mueller, A., Payandeh, Z., Mohammadkhani, N., Mubarak, S. M. H., Zakeri, A., Bahrami, A. A., Brockmueller, A., & Shakibaei, M. (2021) · Cells · doi:10.3390/cells10113017 · Cited by 263 · see citing works
Spaulding, C., Guo, W., & Effros, R. B. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00033-9 · Cited by 258 · see citing works
CD4+CD28− T Lymphocytes Contribute to Early Atherosclerotic Damage in Rheumatoid Arthritis Patients
Gerli, R., Schillaci, G., Giordano, A., Bartoloni, E., Bistoni, O., Vaudo, G., Marchesi, S., Pirro, M., Ragni, F., Shoenfeld, Y., et al. (2004) · Circulation · doi:10.1161/01.cir.0000131450.66017.b3 · Cited by 254 · see citing works
Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis
Yamada, H., Nakashima, Y., Okazaki, K., Mawatari, T., Fukushi, J.-I., Kaibara, N., Hori, A., Iwamoto, Y., & Yoshikai, Y. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.080341 · Cited by 247 · see citing works
CD4+CD28– costimulation-independent T cells in multiple sclerosis
Markovic‐Plese, S., Cortese, I. C. M., Wandinger, K., McFarland, H. F., & Martinꝉ, R. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12516 · Cited by 243 · see citing works
Chemin, K., Gerstner, C., & Malmström, V. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00353 · Cited by 235 · see citing works
Recio-Mayoral, A., Mason, J. C., Kaski, J. C., Rubens, M. B., Harari, O. A., & Camici, P. G. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp205 · Cited by 235 · see citing works
Cutting Edge: CD7 Delivers a Pro-Apoptotic Signal During Galectin-1-Induced T Cell Death
Pace, K. E., Hahn, H. P., Pang, M., Nguyen, J. T., & Baum, L. G. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.5.2331 · Cited by 231 · see citing works
Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.01.002 · Cited by 223 · see citing works
Self-citationVasculitic Peripheral Ulcerative Keratitis
Messmer, E. S. B. M., & Foster, C. S. (1999) · Survey of Ophthalmology · doi:10.1016/s0039-6257(98)00051-4 · Cited by 223 · see citing works
Ruchatz, H., Leung, B. P. L., Wei, X., McInnes, I. B., & Liew, F. Y. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.11.5654 · Cited by 218 · see citing works
Schönland, S. O., Lopez, C., Widmann, T., Zimmer, J., Bryl, E., Goronzy, J. J., & Weyand, C. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2233561100 · Cited by 216 · see citing works
Self-citationGilani, S. R., Vuga, L. J., Lindell, K. O., Gibson, K. F., Xue, J., Kaminski, N., Valentine, V. G., Lindsay, E. K., George, M. P., Steele, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008959 · Cited by 203 · see citing works
Mackay, K., Mack, C., Brophy, S. T., & Călin, A. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199812)41:12 · Cited by 327 · see citing works
Self-citationNamekawa, T., Snyder, M. R., Yen, J., Goehring, B. E., Leibson, P. J., Weyand, C. M., & Goronzy, J. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.2.1138 · Cited by 210 · see citing works
Self-citationVallejo, A. N., Brandes, J. C., Weyand, C. M., & Goronzy, J. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6572 · Cited by 209 · see citing works
Self-citationImmunometabolism in the development of rheumatoid arthritis
Weyand, C. M., & Goronzy, J. J. (2020) · Immunological Reviews · doi:10.1111/imr.12838 · Cited by 193 · see citing works
Self-citationThewissen, M. M., Somers, V. A., Hellings, N., Fraussen, J., Damoiseaux, J. G. M. C., & Stinissen, P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.6514 · Cited by 199 · see citing works
Functional properties of CD4+CD28− T cells in the aging immune system
Weyand, C. M., Brandes, J. C., Schmidt, D., Fulbright, J. W., & Goronzy, J. J. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00161-9 · Cited by 201 · see citing works
Self-citationGoronzy, J. J., & Weyand, C. M. (2003) · Arthritis Research · doi:10.1186/ar974 · Cited by 199 · see citing works
Self-citationSchirmer, M., Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.2.1018 · Cited by 191 · see citing works
Self-citationAutoantibodies in rheumatoid arthritis: rheumatoid factors and anticitrullinated protein antibodies
Song, Y. W., & Kang, E. H. (2009) · QJM · doi:10.1093/qjmed/hcp165 · Cited by 190 · see citing works
Vallejo, A. N., Nestel, A. R., Schirmer, M., Weyand, C. M., & Goronzy, J. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.8119 · Cited by 179 · see citing works
Self-citationBandrés, E., Merino, J., Vázquez, B., Inogés, S., Moreno, C., Subirá, M. L., & Sánchez-Ibarrola, A. (2000) · Clinical Immunology · doi:10.1006/clim.2000.4894 · Cited by 174 · see citing works
Herman, S., Zurgil, N., & Deutsch, M. (2005) · Inflammation Research · doi:10.1007/s00011-005-1355-8 · Cited by 173 · see citing works
Gain and loss of T cell subsets in old age: age-related reshaping of the T cell repertoire.
Arnold, C. R., Wolf, J., Brunner, S., Herndler-Brandstetter, D., & Grubeck-Loebenstein, B. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9499-x · Cited by 170 · see citing works
Prognostic markers of radiographic progression in early rheumatoid arthritis
Goronzy, J. J., Matteson, E. L., Fulbright, J. W., Warrington, K. J., Chang‐Miller, A., Hunder, G. G., Mason, T. G., Nelson, A. M., Valente, R. M., Crowson, C. S., et al. (2004) · Arthritis & Rheumatism · doi:10.1002/art.11445 · Cited by 170 · see citing works
Self-citationMechanisms of Neurodegeneration and Axonal Dysfunction in Progressive Multiple Sclerosis
Correale, J., Marrodan, M., & Ysrraelit, M. C. (2019) · Biomedicines · doi:10.3390/biomedicines7010014 · Cited by 167 · see citing works
Clonality and longevity of CD4+CD28null T cells are associated with defects in apoptotic pathways
Vallejo, A. N., Schirmer, M., Weyand, C. M., & Goronzy, J. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6301 · Cited by 169 · see citing works
Self-citationT-cell aging in rheumatoid arthritis
Weyand, C. M., Yang, Z., & Goronzy, J. J. (2014) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000011 · Cited by 164 · see citing works
Self-citationDysregulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis
Ponchel, F., Morgan, A. W., Bingham, S. J., Quinn, M. A., Buch, M. H., Verburg, R. J., Henwood, J., Douglas, S., Masurel, A., Conaghan, P. G., et al. (2002) · Blood · doi:10.1182/blood-2002-03-0671 · Cited by 165 · see citing works
Analyses of immunosenescent markers in patients with autoimmune disease
Thewissen, M. M., Somers, V. A., Venken, K., Linsen, L., van Paassen, P., Geusens, P., Damoiseaux, J. G. M. C., & Stinissen, P. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.01.005 · Cited by 160 · see citing works
Immunosenescence, autoimmunity, and rheumatoid arthritis
Weyand, C. M., Fulbright, J. W., & Goronzy, J. J. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00090-1 · Cited by 161 · see citing works
Self-citationT-cell metabolism in autoimmune disease
Yang, Z., Matteson, E. L., Goronzy, J. J., & Weyand, C. M. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0542-4 · Cited by 156 · see citing works
Self-citationDeeks, S. G., Verdin, E. M., & McCune, J. M. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.05.004 · Cited by 158 · see citing works
Heat-Shock Protein 60-Reactive CD4 + CD28 null T Cells in Patients With Acute Coronary Syndromes
Zal, B., Kaski, J. C., Arno, G., Akiyu, J. P., Xu, Q., Cole, D., Whelan, M., Russell, N., Madrigal, J. A., Dodi, I. A., et al. (2004) · Circulation · doi:10.1161/01.cir.0000118476.29352.2a · Cited by 155 · see citing works
Autophagy in Autoimmune Disease
Yang, Z., Goronzy, J., & Weyand, C. (2015) · Journal of molecular medicine · doi:10.1007/s00109-015-1297-8 · Cited by 141 · see citing works
Self-citationThe influence of ageing on the development and management of rheumatoid arthritis
Boots, A. M. H., Maier, A. B., Stinissen, P., Masson, P., Lories, R. J. U., & Keyser, F. D. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.92 · Cited by 148 · see citing works
Kochenderfer, J. N., Kobayashi, S., Wieder, E., Su, C., & Molldrem, J. J. (2002) · Blood · doi:10.1182/blood-2002-01-0155 · Cited by 144 · see citing works
Modulation of CD28 expression with anti–tumor necrosis factor α therapy in rheumatoid arthritis
Bryl, E., Vallejo, A. N., Matteson, E. L., Witkowski, J. M., Weyand, C. M., & Goronzy, J. J. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21353 · Cited by 141 · see citing works
Self-citation. Persistent viral infections and immune aging.
Brunner, S., Herndler-Brandstetter, D., Weinberger, B., & Grubeck-Loebenstein, B. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.003 · Cited by 143 · see citing works
Human Cytomegalovirus and Autoimmune Disease
Halenius, A., & Hengel, H. (2014) · BioMed Research International · doi:10.1155/2014/472978 · Cited by 140 · see citing works
T cells and aging (update February 1999)
Pawelec, G. (1999) · Frontiers in bioscience · doi:10.2741/pawelec · Cited by 138 · see citing works
Telomere dysfunction, autoimmunity and aging.
(2011) · Europe PMC (PubMed Central) · Cited by 138 · see citing works
Self-citationRole of CD8 T Cell Replicative Senescence in Human Aging and in HIV-mediated Immunosenescence.
Dock, J., & Effros, R. B. (2011) · Europe PMC (PubMed Central) · Cited by 137 · see citing works
Li, Y., Shen, Y., Hohensinner, P. J., Ju, J., Wen, Z., Goodman, S. B., Zhang, H., Goronzy, J. J., & Weyand, C. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.09.013 · Cited by 138 · see citing works
Self-citationRéthi, B., Fluur, C., Atlas, A., Krzyżowska, M., Mowafi, F., Grützmeier, S., Milito, A. D., Bellocco, R., Falk, K. I., Rajnavölgyi, É., et al. (2005) · AIDS · doi:10.1097/01.aids.0000189848.75699.0f · Cited by 138 · see citing works
Moosig, F., Csernok, E., Wang, G., & Gross, W. L. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00695.x · Cited by 138 · see citing works
Hug, A., Korporal, M., Schröder, I., Haas, J., Glatz, K., Storch-Hagenlocher, B., & Wildemann, B. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.1.432 · Cited by 137 · see citing works
CX3CR1 drives cytotoxic CD4+CD28− T cells into the brain of multiple sclerosis patients
Broux, B., Pannemans, K., Zhang, X., Markovic‐Plese, S., Broekmans, T., Eijnde, B. O., Wijmeersch, B. V., Somers, V. A., Geusens, P., van der Pol, S. M. A., et al. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.11.006 · Cited by 137 · see citing works
Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis
Goronzy, J. J., & Weyand, C. M. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(00)01841-x · Cited by 137 · see citing works
Self-citationGiles, J. T., Szklo, M., Post, W. S., Petri, M., Blumenthal, R. S., Lam, G. K., Gelber, A. C., Detrano, R., Scott, W. W., Kronmal, R. A., et al. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2641 · Cited by 137 · see citing works
Argyriou, A., Wadsworth, M. H., Lendvai, A., Christensen, S. M., Hensvold, A. H., Gerstner, C., van Vollenhoven, A., Kravarik, K. M., Winkler, A. R., Malmström, V., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31519-6 · Cited by 132 · see citing works
The Repertoire of CD4+ CD28− T Cells in Rheumatoid Arthritis
Schmidt, D., Martens, P. B., Weyand, C. M., & Goronzy, J. J. (1996) · Molecular Medicine · doi:10.1007/bf03401644 · Cited by 135 · see citing works
Self-citationPathogenic features of CD4+CD28– T cells in immune disorders
Broux, B., Markovic-Plese, S., Stinissen, P., & Hellings, N. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.06.003 · Cited by 131 · see citing works
The Janus Head of T Cell Aging – Autoimmunity and Immunodeficiency
Goronzy, J. J., Li, G., Yang, Z., & Weyand, C. M. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00131 · Cited by 133 · see citing works
Self-citationSambrook, P. N., MacGregor, A. J., & Spector, T. D. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199902)42:2 · Cited by 517 · see citing works
Lymphocyte Activation as a Possible Measure of Atherosclerotic Risk in Patients with Sleep Apnea
Dyugovskaya, L., Lavie, P., & Lavie, L. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1361.076 · Cited by 132 · see citing works
Premature Immunosenescence in Rheumatoid Arthritis and Multiple Sclerosis Patients
Thewissen, M. M., Linsen, L., Somers, V. A., Geusens, P., Raus, J., & Stinissen, P. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1361.066 · Cited by 131 · see citing works
CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation
Warrington, K. J., Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (2003) · Blood · doi:10.1182/blood-2002-08-2574 · Cited by 132 · see citing works
Self-citationKobayashi, S., Nakano, K., Watanabe, E., Ishigaki, T., Ohno, N., Yuji, K., Oyaizu, N., Asanuma, S., Yamagishi, M., Yamochi, T., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3169 · Cited by 131 · see citing works
Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells
Shen, Y., Wen, Z., Li, Y., Matteson, E. L., Hong, J., Goronzy, J. J., & Weyand, C. M. (2017) · Nature Immunology · doi:10.1038/ni.3808 · Cited by 130 · see citing works
Self-citationDevelopments in the scientific understanding of rheumatoid arthritis
Goronzy, J. J., & Weyand, C. M. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2758 · Cited by 130 · see citing works
Self-citationNakajima, T., Goek, O., Zhang, X., Kopecky, S. L., Frye, R. L., Goronzy, J. J., & Weyand, C. M. (2003) · Circulation Research · doi:10.1161/01.res.0000082333.58263.58 · Cited by 127 · see citing works
Self-citationKim, H. Y., Yoo, T., Hwang, Y., Lee, G. H., Kim, B., Jang, J., Yu, H. T., Kim, M. C., Cho, J., Lee, C. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03130-z · Cited by 128 · see citing works
Heterogeneity of rheumatoid arthritis: from phenotypes to genotypes
Weyand, C. M., Klimiuk, P. A., & Goronzy, J. J. (1998) · Springer Seminars in Immunopathology · doi:10.1007/bf00831996 · Cited by 125 · see citing works
Self-citationThe expansion of CD4+CD28- T cells in patients with rheumatoid arthritis
Pawlik, A., Ostanek, L., Brzosko, I., Brzosko, M., Masiuk, M., Machaliński, B., & Gawronska-Szklarz, B. (2003) · Arthritis Research & Therapy · doi:10.1186/ar766 · Cited by 127 · see citing works
PATHOGENESIS OF RHEUMATOID ARTHRITIS
Weyand, C. M., & Goronzy, J. J. (1997) · Medical Clinics of North America · doi:10.1016/s0025-7125(05)70504-6 · Cited by 127 · see citing works
Self-citationCD4+CD28null T cells in coronary artery disease: when helpers become killers
Dumitriu, I. E., Araguás, E. T., BABOONIAN, C., & Kaski, J. C. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn248 · Cited by 125 · see citing works
Phenotypic and Functional Characterization of CD4 T Cells Expressing Killer Ig-Like Receptors
van Bergen, J., Thompson, A., van der Slik, A. R., Ottenhoff, T. H. M., Gussekloo, J., & Koning, F. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.11.6719 · Cited by 124 · see citing works
- Authors
- Schmidt, D., Goronzy, J. J., & Weyand, C. M.
- Affiliations
- Mayo Clinic (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1996-05-01
- Volume
- 97
- Issue
- 9
- Pages
- 2027-2037
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC507276
- OpenAlex
- W1982865105
- Cited by
- 482
- References
- 43
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 10 · 2023: 5 · 2022: 13 · 2021: 15 · 2020: 12 · 2019: 15 · 2018: 10 · 2017: 18 · 2016: 7 · 2015: 20 · 2014: 12 · 2013: 23 · 2012: 11
- FWCI
- 18.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Arthritis Foundation
- Mayo Foundation for Medical Education and Research
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR041974, R01 AR 41974, R01AR042527, R01AR42527)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- rheumatoid arthritis, CD4+ T cells, clonal expansion, CD28, CD7, autoreactivity, peripheral tolerance, T cell anergy, autoantigens, mixed lymphocyte reaction, T cell proliferation, psoriatic arthritis
- MeSH terms
- Arthritis, Rheumatoid, Autoantigens, Base Sequence, Clone Cells, Humans, Lymphocyte Activation, Molecular Sequence Data, CD4-Positive T-Lymphocytes, Immunophenotyping, T-Lymphocyte Subsets, CD28 Antigens, Antigens, CD7
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