Effects of Dexamethasone, Desoxycorticosterone, and ACTH on Serum Concentrations of Thyroxine, 3, 5, 3′‐Triiodothyronine and 3, 3‘, 5’‐Triiodothyronine
Abstract
ABSTRACT The effects of a pure glucocorticoid, dexamethasone, and a pure mineralocorticoid, desoxycorticosterone, on the serum concentrations of thyroxine (T 4), 3, 5, 3′‐triiodothyronine (T 3), and 3, 3′, 5′‐triiodothyronine (reverse T 3, rT 3) were compared both in healthy subjects and in athyreotic T 4‐substituted patients. In addition, the effect of exogenous ACTH was examined in healthy subjects. Both in healthy subjects and in T 4‐substituted athyreotic patients, administration of a single oral dose of dexamethasone caused a rapid and sharp decrease in the serum concentration of T 3, and a corresponding increase in the serum concentration of rT 3. The T 4 concentration was not changed. A single oral dose of desoxycorticosterone evoked no significant changes in the serum concentrations of T 3, rT 3, or T 4 either in healthy subjects or in T 4‐substituted athyreotic patients. Like dexamethasone, ACTH (two i.v. injections of 60 IU each, at a 6‐hour interval) evoked a serum T 3 reduction and a serum rT 3 increase. Hence, it appears that both endogenous and exogenous glucocorticoids, but not mineralocorticoids, may partially divert the deiodination of T 4 from the activating (T 4←T 3) to the inactivating (T 4←rT 3) pathway.
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There are reports in humans that propranolol and glucocorticoids inhibit T4 to T3 conversion, but data do not indicate these agents increase LT4 requirement in hypothyroid patients.
“Although there are reports in humans that propranolol and glucocorticoids also inhibit T4 to T3 conversion (194,195), there do not seem to be data indicating that these agents increase the requirement for LT4 in hypothyroid patients.”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [195]
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- Authors
- Westgren, U., Ahrén, B., Burger, A., Ingemansson, S., & Melander, A.
- Affiliations
- University of Geneva (CH)
- ORCID
- Burger, A.
- Venue
- Acta Medica Scandinavica
- Publisher
- Wiley
- Published
- 1977-01-12
- Volume
- 202
- Issue
- 1-6
- Pages
- 89-92
- ISSN
- 0001-6101 (ISSN-L)
- OpenAlex
- W1987365698
- Cited by
- 33
- References
- 17
- Citations by year
- 2026: 1 · 2014: 1 · 2013: 1
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Medica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- dexamethasone, deoxycorticosterone, ACTH, thyroxine, triiodothyronine, reverse T3, thyroid hormone deiodination, glucocorticoids, mineralocorticoids, athyreosis, thyroid hormone metabolism
- MeSH terms
- Adrenal Cortex Hormones, Adrenocorticotropic Hormone, Desoxycorticosterone, Dexamethasone, Humans, Thyroxine, Triiodothyronine
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