The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Natural History and Life Expectancy in Severe Alpha1‐Antitrypsin Deficiency, Pi Z
Abstract
ABSTRACT. Clinical data from 246 adult Swedish individuals with severe α 1‐antitrypsin deficiency, Pi Z, diagnosed in 1963‐77, were analyzed. Primary emphysema was present in 109 cases. Of 75 Pi Z patients with other types of chronic obstructive pulmonary disease (COPD), all but 7 showed signs of emphysema. Median age at onset of dyspnoea in Pi Z smokers was 40 years, compared to 53 in non‐smokers (p<0.001). Of the Pi Z individuals over the age of 50, 19% had a diagnosis of liver cirrhosis and 15% signs of glomerular renal damage. Of 91 deceased patients, 56 died from COPD and 12 from liver disease. A greatly reduced survival was demonstrated in Pi Z individuals, regardless of sex. Smoking Pi 2 individuals had a significantly lower life expectancy than Pi Z non‐smokers (p<0.01).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Maximum utilization of the life table method in analyzing survival
Cutler, S. J., & Ederer, F. (1958) · Journal of Chronic Diseases · doi:10.1016/0021-9681(58)90126-7 · Cited by 2,870
Cited by
Replacement Therapy for Alpha1-Antitrypsin Deficiency Associated with Emphysema
Wewers, M. D., Casolaro, M. A., Sellers, S. E., Swayze, S. C., McPhaul, K. M., Wittes, J. T., & Crystal, R. G. (1987) · New England Journal of Medicine · doi:10.1056/nejm198704233161704 · Cited by 641
Risk of Cirrhosis and Primary Liver Cancer in Alpha1-Antitrypsin Deficiency
Eriksson, S., Carlson, J., & Velez, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198603203141202 · Cited by 580
Alpha1-Antitrypsin Deficiency — A Model for Conformational Diseases
Carrell, R. W., & Lomas, D. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmra010772 · Cited by 448
Survival and FEV 1 Decline in Individuals with Severe Deficiency of α 1 -Antitrypsin
The Alpha-1-Antitrypsin Deficiency Registry Study Group (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.1.9712017 · Cited by 435
Matrix metalloproteinases in destructive lung disease
McGarry Houghton, A. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.02.002 · Cited by 172
Metadata
- Authors
- Larsson, C.
- Venue
- Acta Medica Scandinavica
- Publisher
- Wiley
- Published
- 1978-01-12
- Volume
- 204
- Issue
- 1-6
- Pages
- 345-351
- ISSN
- 0001-6101 (ISSN-L)
- OpenAlex
- W2086241735
- Cited by
- 484
- References
- 1
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Natural History and Life Expectancy in Severe Alpha1‐Antitrypsin Deficiency, Pi Z. https://app.cochat.ai/papers/10.1111/j.0954-6820.1978.tb08452.x
- The paper
- Larsson, C. (1978). Natural History and Life Expectancy in Severe Alpha1‐Antitrypsin Deficiency, Pi Z. Acta Medica Scandinavica. https://doi.org/10.1111/j.0954-6820.1978.tb08452.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
