Bonelike Hydroxyapatite Induction by a Gel‐Derived Titania on a Titanium Substrate
Abstract
Gel‐derived titania coating on commercial pure (c.p.) titanium induces hydroxyapatite formation onto its surface from a simulated body fluid (SBF, a metastable calcium phosphate solution). The induced apatite is similar to bone apatite in that it is poorly crystallized, calcium‐deficient, and carbonate‐containing. Furthermore, the carbonate (CO 2–3 ) groups go into the apatite lattice and lie at the positions of PO 3–4 and OH – to replace these ionic groups, resembling the (CO 2–3 ) groups of bone apatite. Therefore, the apatite induced by the gel‐derived titania is said to be bonelike. A chemical stimulation, stemming from abundant hydroxyl groups and negative charges at the surface of the titania gel, is believed to be responsible for the bonelike apatite induction. The potential of bone‐bonding is predicted for the gel‐derived titania, for it is an efficient bonelike apatite inducer in the SBF.
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PDA-assisted surface modification to Ti and Ti alloys offers osteoinductivity to bioinert metallic bone biosubstitutes.
“In addition, the PDA-assisted surface modification to Ti and Ti alloys can also offer the osteoinductivity and osteoconductivity to bioinert metallic bone biosubstitutes and enhance their bioactivities regarding the viability, proliferation, and differentiation of cell and material mineralization [23, 71, 72, 88].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [88]
PDA-assisted surface modification to Ti and Ti alloys offers osteoconductivity to bioinert metallic bone biosubstitutes.
“In addition, the PDA-assisted surface modification to Ti and Ti alloys can also offer the osteoinductivity and osteoconductivity to bioinert metallic bone biosubstitutes and enhance their bioactivities regarding the viability, proliferation, and differentiation of cell and material mineralization [23, 71, 72, 88].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [88]
PDA-assisted surface modification to Ti and Ti alloys enhances cell viability, proliferation, differentiation, and material mineralization.
“In addition, the PDA-assisted surface modification to Ti and Ti alloys can also offer the osteoinductivity and osteoconductivity to bioinert metallic bone biosubstitutes and enhance their bioactivities regarding the viability, proliferation, and differentiation of cell and material mineralization [23, 71, 72, 88].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [88]
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Polydopamine-Assisted Surface Modification for Bone Biosubstitutes
Huang, S., Liang, N., Hu, Y., Zhou, X., & Abidi, N. (2016) · BioMed Research International · doi:10.1155/2016/2389895 · Cited by 97 · see citing works
“Once it is coated by the PDA layer, a special strong charge transfer interaction would be formed between the formed PDA coating layer and Ti, which can offer the biosubstitute a strong corrosive resistance, an improved mechanical properties, and a high superficial energy [87].”
Background
- Authors
- Li, P., Kangasniemi, I., de Groot, K., & Kokubo, T.
- Affiliations
- Leiden University (NL)
- Kyoto University (JP)
- Corresponding author
- Li, Panjian
- ORCID
- Kangasniemi, Ilkka
- Venue
- Journal of the American Ceramic Society
- Publisher
- Wiley
- Published
- 1994-05
- Volume
- 77
- Issue
- 5
- Pages
- 1307-1312
- ISSN
- 0002-7820 (ISSN-L)
- 1551-2916
- OpenAlex
- W2123430124
- Cited by
- 344
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 4 · 2019: 6 · 2018: 9 · 2017: 14 · 2016: 16 · 2015: 12 · 2014: 13 · 2013: 8 · 2012: 13
- FWCI
- 6.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Ceramic Society (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
- Physical Sciences › Materials Science › Materials Chemistry › Titanium Alloys Microstructure and Properties
- Keywords
- titanium substrate, simulated body fluid, calcium phosphate precipitation, calcium-deficient apatite, bone bonding
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