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Hematoporphyrin as a Sensitizer of Cell‐damaging Effect of Ultrasound
Open accessAbstract
Mouse sarcoma 180 or rat ascites hepatoma (AH) 130 cells were exposed to ultrasound (US; 1.27, 2.21 and 3.18 W/cm 2; 1.92 MHz) for up to 60 s in vitro in the presence or absence of hematoporphyrin (Hp; 10, 25 and 50 μg/ml). The cell‐damaging effects of treatments were determined by means of the Trypan Blue dye exclusion test. Hp alone did not show any cell‐damaging effect, whereas US alone damaged 30 and 50% of sarcoma and AH 130 cells, respectively, at the maximum intensity for 60 s. In the presence of 50 μg/ml Hp, US damaged 99 and 95% of the above tumor cells, respectively. These results show that Hp increased the sensitivity of tumor cells to US.
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Cited by
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Lin, X., Song, J., Chen, X., & Yang, H. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201906823 · Cited by 501
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Xing, X., Zhao, S., Xu, T., Huang, L., Zhang, Y., Lan, M., Lin, C., Zheng, X., & Wang, P. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214087 · Cited by 334
Mechanism of Cell Damage by Ultrasound in Combination with Hematoporphyrin
Umemura, S., Yumita, N., Nishigaki, R., & Umemura, K. (1990) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1990.tb02674.x · Cited by 329
Self-citationTreating cancer with sonodynamic therapy: A review
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Metadata
- Authors
- Yumita, N., Nishigaki, R., Umemura, K., & Umemura, S.
- Venue
- Japanese Journal of Cancer Research
- Publisher
- Wiley
- Published
- 1989-03
- Volume
- 80
- Issue
- 3
- Pages
- 219-222
- ISSN
- 0910-5050 (ISSN-L)
- OpenAlex
- W1985749510
- Cited by
- 460
- References
- 0
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yumita, N., Nishigaki, R., Umemura, K., & Umemura, S. (1989). Hematoporphyrin as a Sensitizer of Cell‐damaging Effect of Ultrasound. Japanese Journal of Cancer Research. https://doi.org/10.1111/j.1349-7006.1989.tb02295.x
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