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Synergistic Effect of Ultrasound and Hematoporphyrin on Sarcoma 180
Open accessAbstract
The antitumor effects of combined use of ultrasound (US) and a photosensitizer, hematoporphyrin (Hp), were determined in mice bearing sarcoma 180. In order to find the optimum timing of the US irradiation after the administration of Hp, the Hp concentrations in the tumor and in the plasma were determined and were analyzed pharmacokinetically. Antitumor effects were evaluated by measuring the tumor size and the tumor weight. Hp alone showed no antitumor effect but US alone showed a slight antitumor effect. The combined treatment with US and Hp showed marked synergistic effects on sarcoma 180 (inhibition ratio was 74% of the control). From these results, the enhancement of antitumor effect is thought to be caused by the sensitization of tumor cells to US mediated by Hp.
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Cited by
Free radical formation induced by ultrasound and its biological implications
Riesz, P., & Kondo, T. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90021-8 · Cited by 656
Ultrasound‐Activated Sensitizers and Applications
Lin, X., Song, J., Chen, X., & Yang, H. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201906823 · Cited by 501
Mechanism of Cell Damage by Ultrasound in Combination with Hematoporphyrin
Umemura, S., Yumita, N., Nishigaki, R., & Umemura, K. (1990) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1990.tb02674.x · Cited by 329
Self-citationRecent advances in nanomaterial-based augmented sonodynamic therapy of cancer
Um, W., E. K., P. K., Lee, J., Kim, C. H., You, D. G., & Park, J. H. (2021) · Chemical Communications · doi:10.1039/d0cc07750j · Cited by 120
Metadata
- Authors
- Yumita, N., Nishigaki, R., Umemura, K., & Umemura, S.
- Venue
- Japanese Journal of Cancer Research
- Publisher
- Wiley
- Published
- 1990-03
- Volume
- 81
- Issue
- 3
- Pages
- 304-308
- ISSN
- 0910-5050 (ISSN-L)
- OpenAlex
- W1972025205
- Cited by
- 174
- References
- 0
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yumita, N., Nishigaki, R., Umemura, K., & Umemura, S. (1990). Synergistic Effect of Ultrasound and Hematoporphyrin on Sarcoma 180. Japanese Journal of Cancer Research. https://doi.org/10.1111/j.1349-7006.1990.tb02565.x
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