The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Mesenchymal stem cells (MSC) as therapeutic cytoreagents for gene therapy
Open accessAbstract
We developed human mesenchymal stem cell (MSC) lines that could differentiate into various tissue cells including bone, neural cells, bone marrow (BM) stromal cells supporting the growth of hematopoietic stem cell (HSC), and so‐called ‘tumor stromal cells’ mixing with tumor cells. We investigated the applicability of MSC as therapeutic cell transplanting reagents (cytoreagents). Telomerized human BM derived stromal cells exhibited a prolonged lifespan and supported the growth of hematopoietic clonogenic cells. The gene transfer of Indian hedgehog (Ihh) remarkably enhanced the HSC expansion supported by the human BM stromal cells. Gene‐modified MSC are useful as therapeutic tools for brain tissue damage (e.g. brain infarction) and malignant brain neoplasms. MSC transplantation protected the brain tissue from acute ischemic damage in the midcerebral artery occlusion (MCAO) animal model. Brain‐derived neurotrophic factor (BDNF)‐gene transduction further enhanced the protective efficacy against the ischemic damage. MSC possessed excellent migratory ability and exerted inhibitory effects on the proliferation of glioma cells. Gene‐modification of MSC with therapeutic cytokines clearly augmented the antitumor effect and prolonged the survival of tumor‐bearing animals. Gene therapy employing MSC as a tissue‐protecting and targeting cytoreagent would be a promising approach. (Cancer Sci 2005; 96: 149–156)
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Cites
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
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Wnt proteins are lipid-modified and can act as stem cell growth factors
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Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model
Nakamura, K., Ito, Y., Kawano, Y., Kurozumi, K., Kobune, M., Tsuda, H., Bizen, A., Honmou, O., Niitsu, Y., & Hamada, H. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302276 · Cited by 597
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Cited by
Baksh, D., Yao, R., & Tuan, R. S. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0709 · Cited by 1,058
Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
Khakoo, A. Y., Pati, S., Anderson, S. A., Reid, W., Elshal, M. F., Rovira, I. I., Nguyen, A. T., Malide, D., Combs, C. A., Hall, G., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051921 · Cited by 747
Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells
Spaeth, E., Klopp, A., Dembinski, J., Andreeff, M., & Marini, F. (2008) · Gene Therapy · doi:10.1038/gt.2008.39 · Cited by 579
Adipose Tissue–Derived Human Mesenchymal Stem Cells Mediated Prodrug Cancer Gene Therapy
Kucerova, L., Altanerova, V., Matuskova, M., Tyciakova, S., & Altaner, C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4024 · Cited by 431
Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model
Qiao, L., Xu, Z., Zhao, T., Zhao, Z., Shi, M., Zhao, R. C., Ye, L., & Zhang, X. (2008) · Cell Research · doi:10.1038/cr.2008.40 · Cited by 388
Metadata
- Authors
- Hamada, H., Kobune, M., Nakamura, K., Kawano, Y., Kato, K., Honmou, O., Houkin, K., Matsunaga, T., & Niitsu, Y.
- Venue
- Cancer Science
- Publisher
- Wiley
- Published
- 2005-03
- Volume
- 96
- Issue
- 3
- Pages
- 149-156
- ISSN
- 1347-9032 (ISSN-L)
- 1349-7006
- OpenAlex
- W1991141405
- Cited by
- 208
- References
- 5
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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