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Cited by 388

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model

Open access
Qiao, Ling, Xu, Zhili, Zhao, Tiejun, Zhao, Zhigang, Shi, Mingxia, Zhao, Robert C, Ye, Lihong, Zhang, Xiaodong·2008·Cell Research
DOI 10.1038/cr.2008.40
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Abstract

Human mesenchymal stem cells (hMSCs) can home to tumor sites and inhibit the growth of tumor cells. Little is known about the underlying molecular mechanisms that link hMSCs to the targeted inhibition of tumor cells. In this study, we investigated the effects of hMSCs on two human hepatoma cell lines (H7402 and HepG2) using an animal transplantation model, a co-culture system and conditioned media from hMSCs. Animal transplantation studies showed that the latent time for tumor formation was prolonged and that the tumor size was smaller when SCID mice were injected with H7402 cells and an equal number of Z3 hMSCs. When co-cultured with Z3 cells, H7402 cell proliferation decreased, apoptosis increased, and the expression of Bcl-2, c-Myc, proliferating cell nuclear antigen (PCNA) and survivin was downregulated. After treatment with conditioned media derived from Z3 hMSC cultures, H4702 cells showed decreased colony-forming ability and decreased proliferation. Immunoblot analysis showed that beta-catenin, Bcl-2, c-Myc, PCNA and survivin expression was downregulated in H7402 and HepG2 cells. Taken together, our findings demonstrate that hMSCs inhibit the malignant phenotypes of the H7402 and HepG2 human liver cancer cell lines, which include proliferation, colony-forming ability and oncogene expression both in vitro and in vivo. Furthermore, our studies provide evidence that the Wnt signaling pathway may have a role in hMSC-mediated targeting and tumor cell inhibition.

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Show all 36 references

Research works printed but not linked: 5

  1. Livraghi T, Meloni F, Frosi A . Treatment with stem cell differentiation stage factors of intermediate-advanced hepatocellular carcinoma: an open randomized clinical trial. Oncol Res 2005; 15:399–408. · doi:10.3727/096504005776449716
  2. Omuro Y, Matsumoto G, Sasaki T, et al. Regression of an unresectable pancreatic tumor following nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. Bone Marrow Transplant 2003; 31:943–945. · doi:10.1038/sj.bmt.1703932
  3. Qiao L, Xu ZL, Tan X, et al. Investigation of inhibition of Wnt/β-catenin pathway in breast cancer cells mediated by Dkk-1 released from human mesenchymal stem cells. Prog Biochem Biophys 2007; 34:702–708.
  4. Joubert A, Bianchi P, Maritz C, et al. Influence of prostaglandin A2 on Bax, Bcl-2 and PCNA expression in MCF-7 cells. Biomed Res 2006; 27:157–162. · doi:10.2220/biomedres.27.157
  5. Plas E, Carroll VA, Jilch R, et al. Variations of components of the plasminogen activation system with the cell cycle in benign prostate tissue and prostate cancer. Cytometry 2001; 46:184–189. · doi:10.1002/cyto.1104

Cited by

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Metadata

Authors
Qiao, L., Xu, Z., Zhao, T., Zhao, Z., Shi, M., Zhao, R. C., Ye, L., & Zhang, X.
Venue
Cell Research
Publisher
Springer Science and Business Media LLC
Published
2008-03-25
Volume
18
Issue
4
Pages
500-507
ISSN
  • 1001-0602 (ISSN-L)
  • 1748-7838
DOI
10.1038/cr.2008.40
OpenAlex
W2083808914
Cited by
388
References
36
FWCI
5.95
Type
journal article
Language
en
Open access
hybrid
Licence
www.springer.com/tdm (tdm)

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CoChat. (2026). Citation check: Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model. https://app.cochat.ai/papers/10.1038/cr.2008.40
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Qiao, L., Xu, Z., Zhao, T., Zhao, Z., Shi, M., Zhao, R. C., Ye, L., & Zhang, X. (2008). Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model. Cell Research. https://doi.org/10.1038/cr.2008.40

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.