The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Regulation of cancer cell motility through actin reorganization
Open accessAbstract
Cell migration is a critical step in tumor invasion and metastasis, and regulation of this process will lead to appropriate therapies for treating cancer. Cancer cells migrate in various ways, according to cell type and degree of differentiation. The different types of cell migration are regulated by different mechanisms. Reorganization of the actin cytoskeleton is the primary mechanism of cell motility and is essential for most types of cell migration. Actin reorganization is regulated by Rho family small GTPases such as Rho, Rac, and Cdc42. These small GTPases transmit extracellular chemotactic signals to downstream effectors. Of these downstream effectors, Wiskott–Aldrich syndrome protein (WASP) family proteins are key regulators of cell migration. Activated WASP family proteins induce the formation of protrusive membrane structures involved in cell migration and degradation of the extracellular matrix. Inhibition of Rho family small GTPase signaling suppresses the migration and invasion of cancer cells. Thus, control of cell migration via the actin cytoskeleton provides the possibility of regulating cancer cell invasion and metastasis. (Cancer Sci 2005; 96: 379 – 386)
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck
Eden, S., Rohatgi, R., Podtelejnikov, A. V., Mann, M., & Kirschner, M. W. (2002) · Nature · doi:10.1038/nature00859 · Cited by 835
Takenawa, T., & Miki, H. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.10.1801 · Cited by 604
Self-citationSuetsugu, S., Miki, H., & Takenawa, T. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0894 · Cited by 246
Self-citation
Cited by
Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase
Montalvo-Ortiz, B. L., Castillo-Pichardo, L., Hernández, E., Humphries-Bickley, T., De La Mota-Peynado, A., Cubano, L. A., Vlaar, C. P., & Dharmawardhane, S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.334524 · Cited by 213
Datta, A., Deng, S., Gopal, V., Yap, K. C.-H., Halim, C. E., Lye, M. L., Ong, M. S., Tan, T. Z., Sethi, G., Hooi, S. C., et al. (2021) · Cancers · doi:10.3390/cancers13081882 · Cited by 184
Huang, B., Lu, M., Jolly, M. K., Tsarfaty, I., Onuchic, J., & Ben-Jacob, E. (2014) · Scientific Reports · doi:10.1038/srep06449 · Cited by 91
A 3D Microfluidic Model to Recapitulate Cancer Cell Migration and Invasion
Toh, Y.-C., Raja, A., Yu, H., & Van Noort, D. (2018) · Bioengineering · doi:10.3390/bioengineering5020029 · Cited by 57
Rho A and Rac1: Antagonists moving forward
Salloum, G., Jaafar, L., & El-Sibai, M. (2020) · Tissue and Cell · doi:10.1016/j.tice.2020.101364 · Cited by 36
Deep Genomic Signature for early metastasis prediction in prostate cancer
Sharifi-Noghabi, H., Liu, Y., Erho, N., Shrestha, R., Alshalalfa, M., Davicioni, E., Collins, C. C., & Ester, M. (2018) · doi:10.1101/276055 · Cited by 11
Metadata
- Authors
- Yamazaki, D., Kurisu, S., & Takenawa, T.
- Venue
- Cancer Science
- Publisher
- Wiley
- Published
- 2005-07
- Volume
- 96
- Issue
- 7
- Pages
- 379-386
- ISSN
- 1347-9032 (ISSN-L)
- 1349-7006
- OpenAlex
- W2154154147
- Cited by
- 613
- References
- 3
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
