A 3D Microfluidic Model to Recapitulate Cancer Cell Migration and Invasion
Open accessAbstract
We have developed a microfluidic-based culture chip to simulate cancer cell migration and invasion across the basement membrane. In this microfluidic chip, a 3D microenvironment is engineered to culture metastatic breast cancer cells (MX1) in a 3D tumor model. A chemo-attractant was incorporated to stimulate motility across the membrane. We validated the usefulness of the chip by tracking the motilities of the cancer cells in the system, showing them to be migrating or invading (akin to metastasis). It is shown that our system can monitor cell migration in real time, as compare to Boyden chambers, for example. Thus, the chip will be of interest to the drug-screening community as it can potentially be used to monitor the behavior of cancer cell motility, and, therefore, metastasis, in the presence of anti-cancer drugs.
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Toh et al. described a microfluidic tumor-on-a-chip cell migration model incorporating a microfluidic system to understand cell intravasation.
“Toh et al. described a microfluidic tumor-on-a-chip cell migration model incorporating a microfluidic system to understand the progress of cell intravasation226.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [226]
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- Authors
- Toh, Y.-C., Raja, A., Yu, H., & Van Noort, D.
- Affiliations
- Agency for Science, Technology and Research (SG)
- Division of Biotechnology, IFM, Linköping University, Linköping 58183, Sweden
- Venue
- Bioengineering
- Publisher
- MDPI AG
- Published
- 2018-04-08
- Volume
- 5
- Issue
- 2
- Pages
- 29
- ISSN
- 2306-5354 (ISSN-L)
- PMC
- PMC6027283
- OpenAlex
- W2796168485
- Cited by
- 57
- References
- 42
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 11 · 2019: 7 · 2018: 6 · 2017: 1
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Bioengineering (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- QUT ePrints (Queensland University of Technology) (submittedVersion, cc-by)
- National University of Singapore (submittedVersion)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- tumor cell migration, tumor invasion, basement membrane, metastatic breast cancer, 3D tumor models, real-time cell tracking, drug screening, anticancer drug screening
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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