The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Aminopeptidase N (CD13) as a target for cancer chemotherapy
Open accessAbstract
The enzyme aminopeptidase N (APN, also known as CD13) is a Zn 2+ dependent membrane‐bound ectopeptidase that degrades preferentially proteins and peptides with a N‐terminal neutral amino acid. Aminopeptidase N has been associated with the growth of different human cancers and suggested as a suitable target for anti‐cancerous therapy. Different approaches have been used to develop new drugs directed to this target, including enzyme inhibitors as well as APN‐targeted carrier constructs. This review discusses the prevalence and possible function of APN in malignant diseases, mainly solid tumors, as well as its “drugability” evaluated in preclinical in vivo models, and also provides a brief overview of current clinical trials focused on APN. (Cancer Sci 2011; 102: 501–508)
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Human aminopeptidase N is a receptor for human coronavirus 229E
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Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis.
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Aminopeptidases: structure and function
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The moonlighting enzyme CD13: old and new functions to target
Mina-Osorio, P. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.06.003 · Cited by 405
Role of aminopeptidase N (CD13) in tumor‐cell invasion and extracellular matrix degradation
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CD13/APN is activated by angiogenic signals and is essential for capillary tube formation
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Vascular damage and anti-angiogenic effects of tumor vessel-targeted liposomal chemotherapy.
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Li, H., Kim, Y., Jung, H., Hyun, J. Y., & Shin, I. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00722c · Cited by 356
Positioning of aminopeptidase inhibitors in next generation cancer therapy
Hitzerd, S. M., Verbrugge, S. E., Ossenkoppele, G., Jansen, G., & Peters, G. J. (2014) · Amino Acids · doi:10.1007/s00726-013-1648-0 · Cited by 95
Li, X., Peterson, Y. K., Inks, E. S., Himes, R. A., Li, J., Zhang, Y., Kong, X., & Chou, C. J. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00136 · Cited by 93
Chen, J., Chen, L., Zeng, F., & Wu, S. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c01241 · Cited by 50
Metadata
- Authors
- Wickström, M., Larsson, R., Nygren, P., & Gullbo, J.
- Venue
- Cancer Science
- Publisher
- Wiley
- Published
- 2011-01-30
- Volume
- 102
- Issue
- 3
- Pages
- 501-508
- ISSN
- 1347-9032 (ISSN-L)
- 1349-7006
- OpenAlex
- W2020780403
- Cited by
- 358
- References
- 60
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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