The DOI matches its Crossref record; 176 of the 177 references it cites were found in a registry or an index.
Mindfulness-based treatments for co-occurring depression and substance use disorders: what can we learn from the brain?
Open accessAbstract
Both depression and substance use disorders represent major global public health concerns and are often co-occurring. Although there are ongoing discoveries regarding the pathophysiology and treatment of each condition, common mechanisms and effective treatments for co-occurring depression and substance abuse remain elusive. Mindfulness training has been shown recently to benefit both depression and substance use disorders, suggesting that this approach may target common behavioral and neurobiological processes. However, it remains unclear whether these pathways constitute specific shared neurobiological mechanisms or more extensive components universal to the broader human experience of psychological distress or suffering.We offer a theoretical, clinical and neurobiological perspective of the overlaps between these disorders, highlight common neural pathways that play a role in depression and substance use disorders and discuss how these commonalities may frame our conceptualization and treatment of co-occurring disorders. Finally, we discuss how advances in our understanding of potential mechanisms of mindfulness training may offer not only unique effects on depression and substance use, but also offer promise for treatment of co-occurring disorders.
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“Further, by teaching smokers to focus their attention on what is happening in the moment, mindfulness‐based interventions bring habitual behaviours into consciousness.”
From Mindfulness for smoking cessation (2022) · cites this paper as Brewer 2010
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“This enables people to understand the associative learning process, and focus on affect and craving as central components of positive and negative reinforcement loops (Brewer 2010).”
From Mindfulness for smoking cessation (2022) · cites this paper as Brewer 2010
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“Moreover, ME may contribute to improve problematic smartphone users ' ability to tolerate discomfort associated with craving [14,46].”
From Comparative effectiveness of mind-body exercise versus cognitive behavioral therapy for college students with problematic smartphone use: A randomized controlled trial (2020) · cites this paper as [46]
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“As the positive association between problematic use level and mental health (i.e., loneliness, anxiety and stress) has been established [46,47].”
From Comparative effectiveness of mind-body exercise versus cognitive behavioral therapy for college students with problematic smartphone use: A randomized controlled trial (2020) · cites this paper as [46]
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“However, recent pilot studies have shown that mindfulness may be safe. In this population, it is recommended that practices are shorter, guidance is more frequent, and explicit reference is made to psychotic phenomena.23”
From Mindfulness in psychiatry - Where are we now? (2016) · cites this paper as [23]
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Citations
Cites
The benefits of being present: Mindfulness and its role in psychological well-being
Brown, K. W., & Ryan, R. M. (2003) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.84.4.822 · Cited by 13,448
Cognitive Therapy for Depression
(2012) · PsycEXTRA Dataset · doi:10.1037/e675542012-001 · Cited by 9,678
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · cited 8×
“residential (36,46,51,56) or outpatient settings,(37,40,41,47,53,55,62) three described a clinical sample of adolescents with SUDs (PSR 3/4),(49,52,57) three included a non-clinical sample of substance-using prisoners (PSR 2/4),(44,45,48) and four were based on communityrecruited adults (PSR 2/4) with tobacco (38,43,5…”
Influential(2008) · Medical Entomology and Zoology · Cited by 7,477
Mindfulness: A proposed operational definition.
Bishop, S. R., Lau, M., Shapiro, S., Carlson, L., Anderson, N. D., Carmody, J., Segal, Z. V., Abbey, S., Speca, M., Velting, D., et al. (2004) · Clinical Psychology: Science and Practice · doi:10.1093/clipsy.bph077 · Cited by 7,234 · cited 2×
“It has been hypothesized that focusing and sustaining attention on present experience increases the ability to notice overlearned behavioral patterns as they arise, allowing for individualized interventions (whether cognitive or behavioral) that interrupt these patterns [15,84].”
(1993) · Cited by 7,136
Acceptance and commitment therapy: model, processes and outcomes
Hayes, S. C., Luoma, J. B., Bond, F. W., Masuda, A., & Lillis, J. (2006) · Behaviour Research and Therapy · doi:10.1016/j.brat.2005.06.006 · Cited by 6,587 · cited 1×
“It should be noted that although acceptance is reported to be beneficial in MT as well as therapies that incorporate mindfulness [107,108], it is unclear whether a non-attached viewpoint fosters acceptance, acceptance fosters a nonattached viewpoint, or whether the effects are bidirectional, and to what degree these a…”
Nolen-Hoeksema, S., Wisco, B. E., & Lyubomirsky, S. (2008) · Perspectives on Psychological Science · doi:10.1111/j.1745-6924.2008.00088.x · Cited by 5,172 · cited 2×
“tress without engagement in active problem solving [63],”
Kabat-Zinn, J. (1982) · General Hospital Psychiatry · doi:10.1016/0163-8343(82)90026-3 · Cited by 4,255 · cited 3×
“One of the earliest incorporations of mindfulness into medical treatment paradigms was through the mindfulness-based stress reduction (MBSR) program at the University of Massachusetts [17].”
InfluentialDeep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059
Research works printed but not linked: 3
- Co‐Occurring State Incentive Grants (COSIG) Clinical Protocol Committee, 2006, Definition of the Co‐Occurring Disorders Population
- Marlatt G. A., 2005, Relapse Prevention: Maintenance Strategies in the Treatment of Addictive Behaviors
- 10.1037/0022-3514.75.1.166 · DOI
Cited by
Sorted by citations
Dong, G., & Potenza, M. N. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.07.005 · Cited by 559
Self-citationWitkiewitz, K., & Bowen, S. (2010) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0019172 · Cited by 453
Self-citationMindfulness and Behavior Change
Schuman-Olivier, Z., Trombka, M., Lovas, D. A., Brewer, J. A., Vago, D. R., Gawande, R., Dunne, J. P., Lazar, S. W., Loucks, E. B., & Fulwiler, C. (2020) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000277 · Cited by 435
Self-citationMindfulness training for smoking cessation: Results from a randomized controlled trial
Brewer, J. A., Mallik, S., Babuscio, T. A., Nich, C., Johnson, H. E., Deleone, C. M., Minnix-Cotton, C. A., Byrne, S. A., Kober, H., Weinstein, A. J., et al. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2011.05.027 · Cited by 383
“…hypothesized to not only bring habituated behaviors into consciousness such that they can be worked with effectively, but also target the associative learning process with an emphasis on affect and craving as critical components of positive and negative reinforcement loops (Brewer et al., 2010b).”
BackgroundResultInfluentialSelf-citationBrewer, J. A., Elwafi, H. M., & Davis, J. H. (2013) · Psychology of Addictive Behaviors · doi:10.1037/a0028490 · Cited by 303
“…lead to addictions is beyond the scope of this discussion (Robinson, Sareen, Cox, & Bolton, 2011), another theoretical benefit of MT in the treatment of addictions is that it may concurrently target co-occurring disorders, effectively " killing two birds with one stone " (Brewer et al., 2010).”
InfluentialSelf-citation
Metadata
- Authors
- Brewer, J. A., Bowen, S., Smith, J. T., Marlatt, G. A., & Potenza, M. N.
- Affiliations
- Yale University (US)
- University of Washington (US)
- Corresponding author
- Brewer, Judson A.
- Venue
- Addiction
- Publisher
- Wiley
- Published
- 2010-09-15
- Volume
- 105
- Issue
- 10
- Pages
- 1698-1706
- ISSN
- 0965-2140 (ISSN-L)
- 1360-0443
- PMC
- PMC2905496
- OpenAlex
- W2167010758
- Cited by
- 141
- References
- 177
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 10 · 2020: 11 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 9 · 2015: 11 · 2014: 15 · 2013: 14 · 2012: 10
- FWCI
- 13.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Addiction (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (T32 AA 07455-24, RL1AA017539, T32AA007455)
- National Institute of Mental Health (T32MH019961, R25MH071584)
- National Institute on Drug Abuse (K24DA017899, P50DA009241, K12 DA00167, R01DA020908, P50-DA-0-9241, K12DA000167, T32DA007238)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- mindfulness-based interventions, dual diagnosis, neurobiological mechanisms, psychological distress, substance use disorders, depression
- MeSH terms
- Affect, Attention, Brain, Major Depressive Disorder, Humans, Neural Pathways, Stress, Psychological, Thinking, Cognitive Behavioral Therapy, Diagnosis, Dual (Psychiatry), Meditation, Mind-Body Relations, Metaphysical, Substance-Related Disorders, Secondary Prevention
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