Cited by 453Substance Abuse Treatment and OutcomesMindfulness and Compassion InterventionsOpioid Use Disorder Treatment

Depression, craving, and substance use following a randomized trial of mindfulness-based relapse prevention.

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Witkiewitz, Katie, Bowen, Sarah·2010·Journal of Consulting and Clinical Psychology

Abstract

OBJECTIVE: A strong relation between negative affect and craving has been demonstrated in laboratory and clinical studies, with depressive symptomatology showing particularly strong links to craving and substance abuse relapse. Mindfulness-based relapse prevention (MBRP), shown to be efficacious for reduction of substance use, uses mindfulness-based practices to teach alternative responses to emotional discomfort and lessen the conditioned response of craving in the presence of depressive symptoms. The goal in the current study was to examine the relation between measures of depressive symptoms, craving, and substance use following MBRP. METHOD: Individuals with substance use disorders (N = 168; mean age 40.45 years, SD = 10.28; 36.3% female; 46.4% non-White) were recruited after intensive stabilization, then randomly assigned to either 8 weekly sessions of MBRP or a treatment-as-usual control group. Approximately 73% of the sample was retained at the final 4-month follow-up assessment. RESULTS: Results confirmed a moderated-mediation effect, whereby craving mediated the relation between depressive symptoms (Beck Depression Inventory) and substance use (Timeline Follow-Back) among the treatment-as-usual group but not among MBRP participants. MBRP attenuated the relation between postintervention depressive symptoms and craving (Penn Alcohol Craving Scale) 2 months following the intervention (f(2) = .21). This moderation effect predicted substance use 4 months following the intervention (f(2) = .18). CONCLUSION: MBRP appears to influence cognitive and behavioral responses to depressive symptoms, partially explaining reductions in postintervention substance use among the MBRP group. Although results are preliminary, the current study provides evidence for the value of incorporating mindfulness practice into substance abuse treatment and identifies a potential mechanism of change following MBRP.

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  • Individuals with moderate depression in the MBRP group had a significantly lower probability of substance use, fewer drinks per drinking day, and fewer drinks per day than individuals with moderate depression in TAU.

    “Furthermore, individuals with moderate depression in the MBRP group had a significantly lower probability of substance use, fewer drinks per drinking day, and fewer drinks per day than individuals with moderate depression in TAU.”

    From Relapse prevention for addictive behaviors (2011) · cites this paper as [118]

    The Results (Moderated Mediation Models; page unavailable) report significantly fewer days of substance use among MBRP participants with the highest depressive-symptom scores than comparable TAU participants. The paper does not report the claimed comparisons for probability of substance use, drinks per drinking day, or drinks per day; its reported outcome is days of alcohol or other drug use. (LLM, conf=0.88)

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  • Evidence indicates that mindfulness interventions work through reducing stress and craving and improving mindfulness and interoceptive awareness.

    “Evidence indicates that mindfulness interventions work through reducing stress and craving and improving mindfulness and interoceptive awareness [15,19,20,28–32].”

    From Mindful moms: acceptability and impact of co-designed and digitally delivered video meditations for pregnant and parenting women with opioid use disorder (2025) · cites this paper as [32]

    The Results (Moderated Mediation Models; page unavailable) report lower craving among MBRP participants with higher depressive symptoms than comparable treatment-as-usual participants. The Mindfulness-Based Relapse Prevention section says the practices are intended to increase awareness of physical and emotional states, but the paper does not establish reduced stress or improved mindfulness and interoceptive awareness as measured mechanisms. Its evidence for craving is also more specific than a general claim about how mindfulness interventions work. (LLM, conf=0.86)

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  • The findings are consistent with other studies that have demonstrated the positive impact of mindfulness interventions on stress and mindfulness constructs.

    “Our findings are consistent with other studies that have demonstrated the positive impact of mindfulness interventions on stress and mindfulness constructs [12,15,16,19,20,25–27,30,32].”

    From Mindful moms: acceptability and impact of co-designed and digitally delivered video meditations for pregnant and parenting women with opioid use disorder (2025) · cites this paper as [32]

    The Mindfulness-Based Relapse Prevention section reports greater increases in the ‘acting with awareness’ mindfulness subscale among intervention participants than controls. The Discussion suggests that mindfulness training may improve responses to negative emotional states, but this paper does not demonstrate an effect on stress as a measured outcome. Its Limitations section also says changes in measured mindfulness skills did not explain the current study’s findings. (LLM, conf=0.86)

    Experimental — accuracy not yet measured
  • Therapies that teach people to respond more flexibly in the presence of emotions increase healthy variation that can help them address diverse problems such as chronic pain, substance use, tinnitus, worksite stress, and suicidal behavior.

    “Therapies that teach people to respond more flexibly in the presence of emotions increase healthy variation that can help them rise to the challenge of diverse problems such as chronic pain (e.g., Wicksell et al. 2009), substance use (e.g., Witkiewitz & Bowen 2010), tinnitus (e.g., Westin et al. 2011, worksite stress (Flaxman & Bond 2010), or suicidal behavior (Berking et al. 2009).”

    From Evolving the future: Toward a science of intentional change (2014) · cites this paper as Witkiewitz & Bowen 2010

  • Compared to TAU, MBRP participants evinced a decreased relation between depressive symptoms and craving following treatment.

    “Secondary analyses [118] showed that compared to TAU, MBRP participants evinced a decreased relation between depressive symptoms and craving following treatment.”

    From Relapse prevention for addictive behaviors (2011) · cites this paper as [118]

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Research works printed but not linked: 4

  1. Bowen S Chawla N Marlatt G Mindfulness-based relapse prevention for substance use disorders: A clinician’s guide NY Guilford Press (in press)
  2. Gorski TT The Gorski-Cenaps Model for Recovery and Rrelapse Prevention 2007 Missouri Herald House/Independence Press
  3. Miller WR Tonigan JS Longabaugh R Mattson ME The Drinker Inventory of Consequences (DrInC) Project MATCH Monograph Series Vol. 4 1995 Rockville, MD National Institute on Alcohol Abuse and Alcoholism
  4. Sobell LC Sobell MB Litten RZ Allen J A technique for assessing self-reported alcohol consumption Measuring Alcohol Consumption: Psychosocial and Biological Methods 1992 New Jersey Humana Press

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Authors
Witkiewitz, K., & Bowen, S.
Affiliations
University of Washington (US)
Venue
Journal of Consulting and Clinical Psychology
Published
2010-06
Volume
78
Issue
3
Pages
362-374
ISSN
  • 0022-006X (ISSN-L)
  • 1939-2117
OpenAlex
W2007429684
Cited by
453
References
78
Citations by year
2026: 6 · 2025: 19 · 2024: 16 · 2023: 25 · 2022: 26 · 2021: 27 · 2020: 48 · 2019: 29 · 2018: 28 · 2017: 32 · 2016: 44 · 2015: 39 · 2014: 33 · 2013: 32 · 2012: 29
FWCI
18.62
Type
journal article
Language
en
Open access
Locations
  • Journal of Consulting and Clinical Psychology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Drug Abuse (R21 DA010562)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords
mindfulness-based relapse prevention, substance use disorders, depressive symptoms, craving, alcohol craving, relapse prevention, negative affect, moderated mediation, mechanisms of change, addiction treatment
MeSH terms
Adolescent, Adult, Aged, Ethanol, Alcoholism, Depressive Disorder, Female, Follow-Up Studies, Humans, Male, Middle Aged, Motivation, Illicit Drugs, Substance Withdrawal Syndrome, Meditation, Substance-Related Disorders, Secondary Prevention, Young Adult

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