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Cited by 204Gastroesophageal reflux and treatmentsGastrointestinal motility and disordersEsophageal Cancer Research and Treatment

The DOI matches its Crossref record; 118 of the 119 references it cites were found in a registry or an index.

The role of the hiatus hernia in gastro‐oesophageal reflux disease

Gordon, C., Kang, J. Y., Neild, P. J., Maxwell, J. D.·2004·Alimentary Pharmacology & Therapeutics
DOI 10.1111/j.1365-2036.2004.02149.x
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Abstract

Summary: A sliding hiatus hernia disrupts both the anatomy and physiology of the normal antireflux mechanism. It reduces lower oesophageal sphincter length and pressure, and impairs the augmenting effects of the diaphragmatic crus. It is associated with decreased oesophageal peristalsis, increases the cross‐sectional area of the oesophago‐gastric junction, and acts as a reservoir allowing reflux from the hernia sac into the oesophagus during swallowing. The overall effect is that of increased oesophageal acid exposure. The presence of a hiatus hernia is associated with symptoms of gastro‐oesophageal reflux, increased prevalence and severity of reflux oesophagitis, as well as Barrett's oesophagus and oesophageal adenocarcinoma. The efficacy of treatment with proton pump inhibitors is reduced. Our view on the significance of the sliding hiatus hernia in gastro‐oesophageal reflux disease has changed enormously in recent decades. It was initially thought that a hiatus hernia had to be present for reflux oesophagitis to occur. Subsequently, the hiatus hernia was considered an incidental finding of little consequence. We now appreciate that the hiatus hernia has major patho‐physiological effects favouring gastro‐oesophageal reflux and hence contributing to oesophageal mucosal injury, particularly in patients with severe gastro‐oesophageal reflux disease.

Overview

Integrity signals

Registry

Crossref · 10.1111/j.1365-2036.2004.02149.x

Cites

118 of 118 references verified0 citation errors · 0 not checkable

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Verification

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Citations

Cites

Research works printed but not linked: 3

  1. Cohen S, 1972, Gastroenterology, 1066
  2. Chaiken B., 1968, Familial occurrence of esophageal hiatus hernia (abstract), Gastroenterology, 54, 1224
  3. Rice TW., 2002, Esophageal Surgery, 407

Cited by

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Metadata

Authors
Gordon, C., Kang, J. Y., Neild, P. J., & Maxwell, J. D.
Affiliations
St George's Hospital (GB)
Corresponding author
Kang, J. Y.
ORCID
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2004-09-16
Volume
20
Issue
7
Pages
719-732
ISSN
  • 0269-2813 (ISSN-L)
  • 1365-2036
DOI
10.1111/j.1365-2036.2004.02149.x
OpenAlex
W2004830815
Cited by
204
References
119
Citations by year
2026: 4 · 2025: 16 · 2024: 14 · 2023: 9 · 2022: 9 · 2021: 13 · 2020: 10 · 2019: 7 · 2018: 9 · 2017: 10 · 2016: 10 · 2015: 11 · 2014: 8 · 2013: 10 · 2012: 16
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Alimentary Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
Keywords
gastroesophageal reflux disease, antireflux mechanism, lower esophageal sphincter, esophageal peristalsis, esophageal acid exposure, reflux esophagitis, Barrett's esophagus, esophageal adenocarcinoma, proton pump inhibitors
MeSH terms
Esophagogastric Junction, Gastric Acid, Gastroesophageal Reflux, Hernia, Hiatal, Humans, Manometry, Obesity, Peristalsis, Incidence, Prevalence, Endoscopy, Gastrointestinal

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.