The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Prolonged n‐3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non‐alcoholic fatty liver disease: a pilot study
Abstract
Summary: Background Recent studies suggest a role of n‐3 long‐chain polyunsaturated fatty acids (n‐3 PUFA) as peroxisome proliferator‐activated receptor‐ α ligands in improving non‐alcoholic fatty liver disease (NAFLD) in rodents. However, data in humans are still lacking. Aim To evaluate the efficacy of prolonged PUFA supplementation in patients with NAFLD. Methods Fifty‐six patients with NAFLD were enrolled. Among the overall eligible patients, 42 assumed n‐3 PUFA 1‐g capsule daily for 12 months, whereas 14 refused the treatment and were analysed as controls. All patients underwent haematochemical and ultrasound follow‐up. Results Polyunsaturated fatty acid supplementation significantly decreased serum aspartate transaminase ( P = 0.003), alanine transaminase ( P = 0.002), γ ‐glutamyl transpeptidase ( P = 0.03), triglycerides ( P = 0.02) and fasting glucose ( P = 0.02) in comparison with controls. Circulating arachidonate and n‐6/n‐3 fatty acid ratio was reduced ( P = 0.0002, and P = 0.0001 respectively) in treated patients. Moreover, ultrasonography demonstrated improvement of liver echotexture after PUFA ( P = 0.0001), and increase of Doppler perfusion index ( P = 0.001), whereas no significant changes occurred in controls. Conclusions Supplementation with n‐3 PUFA improves biochemical, ultrasonographic and haemodynamic features of liver steatosis. Our study supports the efficacy of n‐3 PUFA as a new therapeutic approach in the treatment of NAFLD.
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Cites
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Nonalcoholic Fatty Liver Disease
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Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression
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Cited by
Chalasani, N., Younossi, Z., Lavine, J. E., Charlton, M., Cusi, K., Rinella, M., Harrison, S. A., Brunt, E. M., & Sanyal, A. J. (2018) · Hepatology · doi:10.1002/hep.29367 · Cited by 7,239
Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis
Parker, H. M., Johnson, N. A., Burdon, C. A., Cohn, J. S., O’Connor, H. T., & George, J. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.08.018 · Cited by 569
Lipid accumulation in non-adipose tissue and lipotoxicity
van Herpen, N. A., & Schrauwen-Hinderling, V. B. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.049 · Cited by 500
Omega-3 Fatty Acids, Hepatic Lipid Metabolism, and Nonalcoholic Fatty Liver Disease
Scorletti, E., & Byrne, C. D. (2013) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161230 · Cited by 326
Sanyal, A. J., Abdelmalek, M. F., Suzuki, A., Cummings, O. W., & Chojkier, M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.04.046 · Cited by 309
Metadata
- Authors
- CAPANNI, M., CALELLA, F., BIAGINI, M. R., GENISE, S., RAIMONDI, L., BEDOGNI, G., SVEGLIATI‐BARONI, G., SOFI, F., MILANI, S., ABBATE, R., SURRENTI, C., & CASINI, A.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2006-03-30
- Volume
- 23
- Issue
- 8
- Pages
- 1143-1151
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2102656403
- Cited by
- 410
- References
- 8
- FWCI
- 15.49
- Type
- journal article
- Language
- en
- Open access
- closed
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