White spotting in the domestic cat (Felis catus) maps near KIT on feline chromosome B1
Open accessAbstract
Five feline-derived microsatellite markers were genotyped in a large pedigree of cats that segregates for ventral white spotting. Both KIT and EDNRB cause similar white spotting phenotypes in other species. Thus, three of the five microsatellite markers chosen were on feline chromosome B1 in close proximity to KIT; the other two markers were on feline chromosome A1 near EDNRB. Pairwise linkage analysis supported linkage of the white spotting with the three chromosome B1 markers but not with the two chromosome A1 markers. This study indicates that KIT, or another gene within the linked region, is a candidate for white spotting in cats. Platelet-derived growth factor alpha (PDGFRA) is also a strong candidate, assuming that the KIT-PDGFRA linkage group, which is conserved in many mammalian species, is also conserved in the cat.
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The KIT gene is located on cat chromosome B1 and is primarily involved in melanocyte migration, proliferation, and survival.
“The KIT gene, located on cat chromosome B1 (66), is primarily involved in melanocyte migration, proliferation, and survival (67).”
From Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication (2014) · cites this paper as [66]
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Self-citationA High-Resolution 15,000<sub>Rad</sub> Radiation Hybrid Panel for the Domestic Cat
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- Authors
- Cooper, M. P., Fretwell, N., Bailey, S. J., & Lyons, L. A.
- Affiliations
- University of California, Davis (US)
- Waltham Centre for Pet Nutrition (GB)
- Corresponding author
- Lyons, L. A.
- ORCID
- Lyons, L. A.
- Venue
- Animal Genetics
- Publisher
- Wiley
- Published
- 2005-11-23
- Volume
- 37
- Issue
- 2
- Pages
- 163-165
- ISSN
- 0268-9146 (ISSN-L)
- 1365-2052
- PMC
- PMC1464422
- OpenAlex
- W2057585604
- Cited by
- 44
- References
- 13
- Citations by year
- 2026: 2 · 2024: 3 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 8
- FWCI
- 0.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Animal Genetics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Winn Feline Foundation
- School of Veterinary Medicine, University of California, Davis
- National Institutes of Health
- University of California, Davis
- National Cancer Institute
- National Center for Research Resources (R24RR016094, RR016094)
- Center for Companion Animal Health, University of California, Davis
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Keywords
- white spotting, cats, KIT gene, endothelin B receptor, microsatellite markers, linkage analysis, pedigree, PDGFRA, candidate genes, coat color inheritance
- MeSH terms
- Animals, Cats, Chromosome Mapping, Genetic Markers, Hair Color, Lod Score, Phenotype, Skin Pigmentation, Microsatellite Repeats, Proto-Oncogene Proteins c-kit, Chromosomes, Mammalian
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