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Age as a determinant of sensitivity to warfarin.
Open accessAbstract
1 Parallel human and rat studies were carried out to confirm the previous suggestion of an increased sensitivity to warfarin in old age. 2 The anticoagulant response to warfarin was found to be greater in the elderly groups despite, in the case of the patient study, the elderly subjects being given a smaller weight‐related dose. 3 At the same plasma warfarin concentrations there was greater inhibition of vitamin K‐dependent clotting factor synthesis in the elderly. There was no difference in the rate of clotting factor degradation in the two age groups. 4 There was no appreciable difference in warfarin pharmacokinetics (plasma half‐life, apparent volume of distribution, plasma clearance, plasma protein binding or plasma warfarin alcohol levels) in the two age groups. 5 There appeared to be no major age‐ related differences in warfarin pharmacokinetics and the increased effect of warfarin in the elderly seemed to result from an increased intrinsic sensitivity to warfarin.
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Citations
Cited by
Aging Biology and Geriatric Clinical Pharmacology
McLean, A. J., & Le Couteur, D. G. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.2.4 · Cited by 771
Greenblatt (1982) · doi:10.1056/nejm198205063061804 · Cited by 584
Management of drug therapy in the elderly
Desforges, J. F., Montamat, S. C., Cusack, B. J., & Vestal, R. E. (1989) · New England Journal of Medicine · doi:10.1056/nejm198908033210507 · Cited by 388
Holford, N. H. G. (1986) · Clinical Pharmacokinetics · doi:10.2165/00003088-198611060-00005 · Cited by 360
Petsophonsakul, P., Furmanik, M., Forsythe, R., Dweck, M., Schurink, G. W., Natour, E., Reutelingsperger, C., Jacobs, M., Mees, B., & Schurgers, L. (2019) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.119.312787 · Cited by 341
Metadata
- Authors
- Shepherd, A., Hewick, D., Moreland, T., & Stevenson, I.
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 1977-06
- Volume
- 4
- Issue
- 3
- Pages
- 315-320
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- OpenAlex
- W1987531347
- Cited by
- 262
- References
- 0
- FWCI
- 10.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shepherd, A., Hewick, D., Moreland, T., & Stevenson, I. (1977). Age as a determinant of sensitivity to warfarin. British Journal of Clinical Pharmacology. https://doi.org/10.1111/j.1365-2125.1977.tb00719.x
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