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Stereoselective disposition of ibuprofen enantiomers in infants.
Open accessAbstract
The pharmacokinetics of the enantiomers of ibuprofen were investigated after oral administration of a single 7.6 +/‐ 0.3 mg kg‐1 dose of the racemate in 11 infants. Mean (+/‐ s.d.) half‐lives were 1.6 +/‐ 0.5 h for S(+) and 1.5 +/‐ 0.5 h for R(‐) and mean (+/‐ s.d.) AUC values were 31.5 +/‐ 14.3 mg l‐1 h for S(+) and 36.6 +/‐ 13.8 mg l‐1 h for R(‐). Since plasma concentrations of the active S(+)‐isomer were lower than those reported in adults, a higher dosage might be required in infants.
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Citations
Cited by
Role of Pharmacokinetics and Metabolism in Drug Discovery and Development
Lin, J. H., & Lu, A. Y. H. (1997) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01340-1 · Cited by 708
Ibuprofen: pharmacology, efficacy and safety
Rainsford, K. D. (2009) · Inflammopharmacology · doi:10.1007/s10787-009-0016-x · Cited by 667
Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity
Fromenty, B., & Pessayre, D. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)00012-6 · Cited by 665
Zhao, Y. H., Le, J., Abraham, M. H., Hersey, A., Eddershaw, P. J., Luscombe, C. N., Boutina, D., Beck, G., Sherborne, B., Cooper, I., et al. (2001) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.1031 · Cited by 526
Clinical Pharmacokinetics of Ibuprofen: The First 30 Years
Davies, N. M. (1998) · Clinical Pharmacokinetics · doi:10.2165/00003088-199834020-00002 · Cited by 440
Metadata
- Authors
- Rey, E., Pariente‐Khayat, A., Gouyet, L., Vauzelle‐Kervroedan, F., Pons, G., D'Athis, P., Dubois, M., Murat, I., Lassale, C., & Goehrs, M.
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 1994-10
- Volume
- 38
- Issue
- 4
- Pages
- 373-375
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- OpenAlex
- W2146531250
- Cited by
- 212
- References
- 0
- FWCI
- 10.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Stereoselective disposition of ibuprofen enantiomers in infants. https://app.cochat.ai/papers/10.1111/j.1365-2125.1994.tb04369.x
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- Rey, E., Pariente‐Khayat, A., Gouyet, L., Vauzelle‐Kervroedan, F., Pons, G., D'Athis, P., Dubois, M., Murat, I., Lassale, C., & Goehrs, M. (1994). Stereoselective disposition of ibuprofen enantiomers in infants. British Journal of Clinical Pharmacology. https://doi.org/10.1111/j.1365-2125.1994.tb04369.x
Data sources
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
