The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Role of Pharmacokinetics and Metabolism in Drug Discovery and Development
Abstract
Drug research encompasses several diverse disciplines united by a common goal, namely the development of novel therapeutic agents. The search for new drugs can be divided functionally into two stages: discovery and development. The former consists of setting up a working hypothesis of the target
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Cites
Shimada, T., Yamazaki, H., Mimura, M., Inui, Y., & Guengerich, F. P. (1994) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22379-5 · Cited by 2,785 · cited 1×
“…et al. (1996) successfully predicted the in vivo clearance and bioavailability of YM796, a CNS drug for the treatment of Alzheimer’s disease, using a recombinant system of human CYP3A4 together with the information of the content of this isoform in human liver microsomes (Shimada et al., 1994).”
Terfenadine-Ketoconazole Interaction: Pharmacokinetic and Electrocardiographic Consequences
Honig, P. K. (1993) · JAMA · doi:10.1001/jama.1993.03500120051025 · Cited by 664
Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data
Iwatsubo, T., Hirota, N., Ooie, T., Suzuki, H., Shimada, N., Chiba, K., Ishizaki, T., Green, C. E., Tyson, C. A., & Sugiyama, Y. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(96)00184-2 · Cited by 479
Pharmaceutical innovation by the seven UK‐owned pharmaceutical companies (1964‐1985).
Prentis, R., Lis, Y., & Walker, Sr. (1988) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1988.tb03318.x · Cited by 471
Cited by
Laboratory of Toxicology, F. O. P., Chuong, P.-H., Nguyen, L. A., Department of Pharmacy, L. S. P. C. H., He, H., & Department of Analytical Chemistry, C. P. U. (2006) · International Journal of Biomedical Science · doi:10.59566/ijbs.2006.2085 · Cited by 1,224
Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds
Ramesh, R., & Reddy, D. S. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00718 · Cited by 624
Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome
Li, H., Guan, Y., Liang, B., Ding, P., Hou, X., Wei, W., & Ma, Y. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175091 · Cited by 258
(1998) · PubMed · Cited by 176
Richards, E. M., Mathews, D. C., Luckenbaugh, D. A., Ionescu, D. F., Machado-Vieira, R., Niciu, M. J., Duncan, W. C., Nolan, N. M., Franco-Chaves, J. A., Hudzik, T., et al. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4195-4 · Cited by 76
Metadata
- Authors
- Lin, J. H., & Lu, A. Y. H.
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 1997-12
- Volume
- 49
- Issue
- 4
- Pages
- 403-449
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W2153246785
- Cited by
- 708
- References
- 4
- FWCI
- 13.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lin, J. H., & Lu, A. Y. H. (1997). Role of Pharmacokinetics and Metabolism in Drug Discovery and Development. Pharmacological Reviews. https://doi.org/10.1016/s0031-6997(24)01340-1
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
