The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Relationship between polypharmacy and underprescribing
Open accessAbstract
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Polypharmacy is common among the elderly. • Underprescribing is also frequent. • Optimizing polypharmacy includes avoiding underprescription. WHAT THIS STUDY ADDS • The probability of underprescription increases with the number of drugs used. • Forty‐three % of patients who used five or more medicines are undertreated. • In undertreated patients a mean of 1.4 medicines were lacking. AIMS: Underprescribing is increasingly recognized as an important problem. The aim of this study was to determine the relationship between polypharmacy and underprescribing. METHODS: Treatment of current medical problems in geriatric patients was compared with general practitioner and national guidelines. Underprescription was defined as lack of an indicated drug, while no reason could be found for not prescribing it. Polypharmacy was defined as five or more drugs. RESULTS: Polypharmacy was present in 61% of 150 patients. Underprescription was found in 47 (31%). Of patients with polypharmacy 42.9% were undertreated, in contrast to 13.5% of patients using four medicines or less (OR 4.8, 95% CI 2.0, 11.2). The estimated probability of underprescription increased significantly with the number of drugs. CONCLUSIONS: We found a clear relationship between polypharmacy and underprescribing.
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Boyd, C. M., Darer, J., Boult, C., Fried, L. P., Boult, L., & Wu, A. W. (2005) · JAMA · doi:10.1001/jama.294.6.716 · Cited by 2,581
Cited by
An update on the clinical consequences of polypharmacy in older adults: a narrative review
Wastesson, J. W., Morin, L., Tan, E. C. K., & Johnell, K. (2018) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2018.1546841 · Cited by 617
Nobili, A., Garattini, S., & Mannucci, P. M. (2011) · Journal of Comorbidity · doi:10.15256/joc.2011.1.4 · Cited by 300
Schneider, J., Algharably, E. A. E., Budnick, A., Wenzel, A., Dräger, D., & Kreutz, R. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.686990 · Cited by 70
Metadata
- Authors
- Kuijpers, M. A. J., Van Marum, R. J., Egberts, A. C. G., Jansen, P. A. F., & The OLDY (OLd people Drugs & dYsregulations) study group
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2007-12-14
- Volume
- 65
- Issue
- 1
- Pages
- 130-133
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- OpenAlex
- W2171692026
- Cited by
- 253
- References
- 1
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kuijpers, M. A. J., Van Marum, R. J., Egberts, A. C. G., Jansen, P. A. F., & The OLDY (OLd people Drugs & dYsregulations) study group. (2008). Relationship between polypharmacy and underprescribing. British Journal of Clinical Pharmacology. https://doi.org/10.1111/j.1365-2125.2007.02961.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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