High Prevalence of Multimorbidity and Polypharmacy in Elderly Patients With Chronic Pain Receiving Home Care are Associated With Multiple Medication-Related Problems
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Aim: To measure the extent of polypharmacy, multimorbidity and potential medication-related problems in elderly patients with chronic pain receiving home care. Methods: Data of 355 patients aged ≥65 years affected by chronic pain in home care who were enrolled in the ACHE study in Berlin, Germany, were analyzed. History of chronic diseases, diagnoses, medications including self-medication were collected for all patients. Multimorbidity was defined as the presence of ≥2 chronic conditions and levels were classified by the Charlson-Comorbidity-Index. Polypharmacy was defined as the concomitant intake of ≥5 medications. Potentially clinically relevant drug interactions were identified and evaluated; underuse of potentially useful medications as well as overprescription were also assessed. Results: More than half of the patients (55.4%) had moderate to severe comorbidity levels. The median number of prescribed drugs was 9 (range 0–25) and polypharmacy was detected in 89.5% of the patients. Almost half of them (49.3%) were affected by excessive polypharmacy (≥10 prescribed drugs). Polypharmacy and excessive polypharmacy occurred at all levels of comorbidity. We detected 184 potentially relevant drug interactions in 120/353 (34.0%) patients and rated 57 (31.0%) of them as severe. Underprescription of oral anticoagulants was detected in 32.3% of patients with atrial fibrillation whereas potential overprescription of loop diuretics was observed in 15.5% of patients. Conclusion: Multimorbidity and polypharmacy are highly prevalent in elderly outpatients with chronic pain receiving home care. Medication-related problems that could impair safety of drug treatment in this population are resulting from potentially relevant drug interactions, overprescribing as well as underuse.
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In many countries, patients receiving home care services typically live with comorbid conditions and have high functional and cognitive impairment rates.
“In many countries worldwide, patients receiving home care services typically live with comorbid conditions, with high functional and cognitive impairment rates [30–32].”
From The hospital-to-home care transition experience of home care clients: an exploratory study using patient journey mapping (2023) · cites this paper as [31]
The Results (Study Population; page unavailable) report 91.6% multimorbidity and Table 1 reports cognitive-impairment categories and care levels. But the study covers older adults with chronic pain receiving home care in Berlin, not home-care patients across many countries. Care level reflects dependence, but the paper does not report a functional-impairment rate as such. (LLM, conf=0.86)
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Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742 · see citing works
Validation of a combined comorbidity index
Charlson, M., Szatrowski, T. P., Peterson, J., & Gold, J. (1994) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(94)90129-5 · Cited by 6,587 · see citing works
The Mini‐Mental State Examination: A Comprehensive Review
Tombaugh, T. N., & McIntyre, N. J. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb01992.x · Cited by 5,152 · see citing works
What is polypharmacy? A systematic review of definitions
Masnoon, N., Shakib, S., Ellett, L. M. K., & Caughey, G. E. (2017) · BMC Geriatrics · doi:10.1186/s12877-017-0621-2 · Cited by 3,444 · see citing works
Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J., Blomström-Lundqvist, C., Boriani, G., Castellá, M., Dan, G., Dilaveris, P. E., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa612 · Cited by 2,605 · see citing works
Clinical consequences of polypharmacy in elderly
Maher, R. L., Hanlon, J. T., & Hajjar, E. R. (2013) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2013.827660 · Cited by 1,970 · see citing works
Diederichs, C., Berger, K., & Bartels, D. B. (2011) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glq208 · Cited by 693 · see citing works
An update on the clinical consequences of polypharmacy in older adults: a narrative review
Wastesson, J. W., Morin, L., Tan, E. C. K., & Johnell, K. (2018) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2018.1546841 · Cited by 617 · see citing works
Multimorbidity in chronic disease: impact on health care resources and costs
McPhail, S. (2016) · Risk Management and Healthcare Policy · doi:10.2147/rmhp.s97248 · Cited by 555 · see citing works
Causes of international increases in older age life expectancy
Mathers, C. D., Stevens, G. A., Boerma, T., White, R. A., & Tobias, M. I. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60569-9 · Cited by 438 · see citing works
Afshar, S., Roderick, P. J., Kowal, P. R., Dimitrov, B. D., & Hill, A. G. (2015) · BMC Public Health · doi:10.1186/s12889-015-2008-7 · Cited by 347 · see citing works
Comorbidity in elderly cancer patients in relation to overall and cancer-specific mortality
Jørgensen, T. L., Hallas, J., Friis, S., & Herrstedt, J. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.46 · Cited by 281 · see citing works
Polypharmacy, hospitalization, and mortality risk: a nationwide cohort study
Chang, T. I., Park, H., Kim, D. W., Jeon, E. K., Rhee, C. M., Kalantar‐Zadeh, K., Kang, E. W., Kang, S., & Han, S. H. (2020) · Scientific Reports · doi:10.1038/s41598-020-75888-8 · Cited by 272 · see citing works
Hyperkalemia: pathophysiology, risk factors and consequences
Hunter, R. W., & Bailey, M. A. (2019) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfz206 · Cited by 268 · see citing works
Relationship between polypharmacy and underprescribing
Kuijpers, M. A. J., van Marum, R. J., Egberts, T. C. G., Jansen, P. A. F., & The OLDY (OLd people Drugs & dYsregulations) study group (2007) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2007.02961.x · Cited by 264 · see citing works
PCNE definition of medication review: reaching agreement
Griese‐Mammen, N., Hersberger, K. E., Messerli, M., Leikola, S. N. S., Horvat, N., van Mil, J. W. F., & Kos, M. (2018) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-018-0696-7 · Cited by 260 · see citing works
Patterns of Multimorbidity in the Aged Population. Results from the KORA-Age Study
Kirchberger, I., Meisinger, C., Heier, M., Zimmermann, A.-K., Thorand, B., Autenrieth, C. S., Peters, A., Ladwig, K., & Döring, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030556 · Cited by 256 · see citing works
Measuring potentially avoidable hospital readmissions
Halfon, P., Eggli, Y., van Melle, G., Chevalier, J., Wasserfallen, J.-B., & Burnand, B. (2002) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(01)00521-2 · Cited by 245 · see citing works
A clinician's guide to statin drug-drug interactions
Kellick, K. A., Bottorff, M. B., & Toth, P. P. (2014) · Journal of clinical lipidology · doi:10.1016/j.jacl.2014.02.010 · Cited by 162 · see citing works
Pain, frailty and comorbidity on older men: The CHAMP study
Blyth, F., Rochat, S., Cumming, R. G., Creasey, H. M., Handelsman, D. J., Couteur, D. G. L., Naganathan, V., Sambrook, P. N., Seibel, M. J., & Waite, L. M. (2008) · Pain · doi:10.1016/j.pain.2008.08.011 · Cited by 150 · see citing works
Mapping the global research landscape and knowledge gaps on multimorbidity: a bibliometric study
Xu, X., Mishra, G. D., & Jones, M. (2017) · Journal of Global Health · doi:10.7189/jogh.07.010414 · Cited by 141 · see citing works
Polypharmacy among inpatients aged 70 years or older in Australia
Hubbard, R. E., Peel, N. M., Scott, I. A., Martin, J. H., Smith, A. J., Pillans, P. I., Poudel, A., & Gray, L. (2015) · The Medical Journal of Australia · doi:10.5694/mja13.00172 · Cited by 108 · see citing works
Abizanda, P., Romero, L., Sánchez‐Jurado, P. M., Martínez-Reig, M., Alfonso-Silguero, S. A., & Rodríguez‐Mañas, L. (2014) · The journal of nutrition health & aging · doi:10.1007/s12603-014-0033-3 · Cited by 106 · see citing works
A Prospective Evaluation of the Charlson Comorbidity Index for Use in Long‐Term Care Patients
Bravo, G., Dubois, M., Hébert, R., Wals, P. D., & Messier, L. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50172.x · Cited by 91 · see citing works
Steinberg, B. A., Greiner, M. A., Hammill, B. G., Curtis, L. H., Benjamin, E. J., Heckbert, S. R., & Piccini, J. P. (2015) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12129 · Cited by 89 · see citing works
Statins and myotoxicity: a therapeutic limitation
Tiwari, A. K., Bansal, V. S., Chugh, A., & Mookhtiar, K. A. (2006) · Expert Opinion on Drug Safety · doi:10.1517/14740338.5.5.651 · Cited by 80 · see citing works
Chronic Pain in the Elderly: The Case for New Therapeutic Strategies
Varrassi, G. (2015) · Pain Physician · doi:10.36076/ppj.2015/18/e863 · Cited by 77 · see citing works
Leong, I., Farrell, M. J., Helme, R. D., & Gibson, S. J. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.5.550 · Cited by 70 · see citing works
Adherence to Pharmacological Treatment of Chronic Nonmalignant Pain in Individuals Aged 65 and Older
Markotić, F., Obrdalj, E. Č., Zalihić, A., Pehar, R., Hadziosmanovic, Z., Pivić, G., Durasovic, S., Grgic, V., Banožić, A., Sapunar, D., et al. (2013) · Pain Medicine · doi:10.1111/pme.12035 · Cited by 58 · see citing works
Sarafidis, P., Georgianos, P., & Lasaridis, A. (2010) · Expert Opinion on Drug Safety · doi:10.1517/14740330903499240 · Cited by 51 · see citing works
Demographic Characteristics and Healthcare Use of Centenarians: A Population‐Based Cohort Study
Rochon, P. A., Gruneir, A., Wu, W., Gill, S. S., Bronskill, S. E., Seitz, D. P., Bell, C. M., Fischer, H. D., Stephenson, A. L., Wang, X., et al. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12613 · Cited by 49 · see citing works
Nawai, A., Leveille, S. G., Shmerling, R. H., van der Leeuw, G., & Bean, J. F. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-016-0700-9 · Cited by 49 · see citing works
Risk factors for polypharmacy in older adults in a primary care setting: a cross-sectional study
Ersoy, S., & Engin, V. S. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s176329 · Cited by 46 · see citing works
Deficits in pain treatment in nursing homes in G ermany: A cross‐sectional study
Kölzsch, M., Wulff, I., Ellert, S., Fischer, T., Köpke, K.-H., Kalinowski, S., Dräger, D., & Kreutz, R. H. (2011) · European Journal of Pain · doi:10.1002/j.1532-2149.2011.00029.x · Cited by 42 · see citing works
Self-citationJokanovic, N., Tan, E. C. K., Dooley, M. J., Kirkpatrick, C. M. J., Elliott, R. A., & Bell, J. S. (2016) · Journal of Evaluation in Clinical Practice · doi:10.1111/jep.12514 · Cited by 36 · see citing works
Fishbain, D. A. (2005) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/01.phm.0000154904.83278.32 · Cited by 36 · see citing works
Zarraga, I. G. E., & Kron, J. (2012) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12042 · Cited by 33 · see citing works
Multimorbidity Profiles in German Centenarians: A Latent Class Analysis of Health Insurance Data
Gellert, P. R., von Berenberg, P., Zahn, T., Neuwirth, J., Kuhlmey, A., & Dräger, D. (2017) · Journal of Aging and Health · doi:10.1177/0898264317737894 · Cited by 33 · see citing works
Self-citationPitkälä, K. H., Suominen, M. H., Bell, J. S., & Strandberg, T. E. (2016) · Annals of Medicine · doi:10.1080/07853890.2016.1197414 · Cited by 32 · see citing works
Devik, S. A., Olsen, R. M., Fiskvik, I. L., Halbostad, T., Lassen, T., Kuzina, N., & Enmarker, I. (2018) · Scandinavian Journal of Primary Health Care · doi:10.1080/02813432.2018.1499581 · Cited by 32 · see citing works
Pain and Multimorbidity in Late Life
Nakad, L., Booker, S. Q., Gilbertson‐White, S., Shaw, C. A., Chi, N., & Herr, K. (2020) · Current Epidemiology Reports · doi:10.1007/s40471-020-00225-6 · Cited by 31 · see citing works
Schneider, J., Algharably, E. A. E., Budnick, A., Wenzel, A., Dräger, D., & Kreutz, R. H. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229229 · Cited by 29 · see citing works
Self-citationMultimorbidity and polypharmacy among elderly people followed in general practices in Germany
Kostev, K., & Jacob, L. (2018) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2018.07.014 · Cited by 27 · see citing works
Diuretics, first-line antihypertensive agents: are they always safe in the elderly?
Diaconu, C. C., Bălăceanu, A. L., & Bartos, D. (2014) · PubMed · Cited by 18 · see citing works
Rabenberg, A., Schulte, T., Hildebrandt, H., & Wehling, M. (2019) · Drugs & Aging · doi:10.1007/s40266-019-00703-7 · Cited by 17 · see citing works
Kreutz, R. H., Schmidt, I. M., Dräger, D., Brüggen, F., Hörter, S., Zwillich, C., Kuhlmey, A., & Gellert, P. R. (2018) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13531 · Cited by 6 · see citing works
Self-citationVerordnung von Antihypertensiva bei geriatrischen Pflegeheimbewohnern in Deutschland
Kölzsch, M., Bolbrinker, J., Dräger, D., Scholze, J., Huber, M., & Kreutz, R. H. (2010) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-0030-1269407 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Mancia, G., Kreutz, R., Brunström, M., Burnier, M., Grassi, G., Januszewicz, A., Muiesan, M. L., Tsioufis, K., Agabiti-Rosei, E., Algharably, E. A. E., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003480 · Cited by 3,473 · see citing works
Self-citationMcMenamin, A., Turi, E., Schlak, A., & Poghosyan, L. (2023) · Medical Care Research and Review · doi:10.1177/10775587231186720 · Cited by 88 · see citing works
Fernández‐Feijoo, F., Samartin-Veiga, N., & Carrillo‐de‐la‐Peña, M. T. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.924405 · Cited by 49 · see citing works
Chen, J., Zhang, F., Zhang, Y., Lin, Z., Deng, K., Hou, Q., Li, L., & Gao, Y. (2024) · BMC Public Health · doi:10.1186/s12889-024-17890-7 · Cited by 33 · see citing works
Saragosa, M., Nizzer, S., McKay, S., & Kuluski, K. (2023) · BMC Health Services Research · doi:10.1186/s12913-023-09899-2 · Cited by 31 · see citing works
Zahlan, G., Clifford‐Faugère, G. D., Nguefack, H. L. N., Guénette, L., Pagé, M. G., Blais, L., & Lacasse, A. (2023) · Journal of Pain Research · doi:10.2147/jpr.s411451 · Cited by 29 · see citing works
Zezai, D., van Rensburg, A. J., Babatunde, G. B., Kathree, T., Cornick, R. V., Levitt, N. S., Fairall, L. R., & Petersen, I. (2024) · BMJ Open · doi:10.1136/bmjopen-2024-087451 · Cited by 26 · see citing works
Huang, W., Wang, X., Chen, Y., Yu, C., & Zhang, S. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1618701 · Cited by 25 · see citing works
Liu, Y., Yang, M. L., Ding, Y., Wang, H., Zhang, H., Wang, D., Zhuang, T., Ji, M., Cui, Y., & Wang, H. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-04207-4 · Cited by 23 · see citing works
Age, Race, Ethnicity, and Sex of Participants in Clinical Trials Focused on Chronic Pain
Boyd, T., Chibueze, J., Pester, B., Saini, R., Bar, N., Edwards, R. R., Adams, M. C. B., Silver, J. K., Meints, S. M., & Murray, H. B. (2024) · Journal of Pain · doi:10.1016/j.jpain.2024.03.007 · Cited by 23 · see citing works
Jungo, K. T., Cheval, B., Sieber, S., van der Linden, B. W. A., Ihle, A., Carmeli, C., Chioléro, A., Streit, S., & Cullati, S. (2022) · PLoS ONE · doi:10.1371/journal.pone.0271298 · Cited by 19 · see citing works
Goudman, L., Moens, M., & Pilitsis, J. G. (2023) · Anesthesiology · doi:10.1097/aln.0000000000004863 · Cited by 17 · see citing works
Pharmacist Intervention in Portuguese Older Adult Care
Rodrigues, A. R., Teixeira‐Lemos, E., Mascarenhas‐Melo, F., Teixeira-Lemos, L. P., & Bell, V. (2022) · Healthcare · doi:10.3390/healthcare10101833 · Cited by 16 · see citing works
Yunus, M. A. A. H. M., Akkawi, M. E., & Nahas, A. R. F. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-05016-y · Cited by 16 · see citing works
Alhalaseh, L., Makahleh, H., Al-Saleem, B., Al-Omran, F., & Schoenmakers, B. (2024) · Clinical Interventions in Aging · doi:10.2147/cia.s462347 · Cited by 14 · see citing works
Dixe, M. D. A., Pinho, J., Pereira, F., Verloo, H., Meyer‐Massetti, C., & Pereira, S. G. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20031701 · Cited by 13 · see citing works
Risk factors of multimorbidity among older adults in India: A systematic review and meta‐analysis
Goel, N., Biswas, I., & Chattopadhyay, K. (2024) · Health Science Reports · doi:10.1002/hsr2.1915 · Cited by 11 · see citing works
Τσεκούρα, Μ., Billis, E. V., Matzaroglou, C., Tsepis, E., & Gliatis, J. (2024) · Healthcare · doi:10.3390/healthcare12131303 · Cited by 11 · see citing works
Gomes, J. V. D., Herz, C., Helmig, S., Förster, N., Mewis, I., & Lamy, E. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.779801 · Cited by 11 · see citing works
Clifford‐Faugère, G. D., Nguefack, H. L. N., Godbout-Parent, M., Diallo, M. A., Guénette, L., Pagé, M. G., Choinière, M., Harden, R. N., Beaudoin, S., Boulanger, A., et al. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.09.010 · Cited by 11 · see citing works
Crunenberg, R., Charles, C., Lallemand, A., Buret, L., Philippe, G., & Ethgen, O. (2024) · Exploratory Research in Clinical and Social Pharmacy · doi:10.1016/j.rcsop.2024.100424 · Cited by 10 · see citing works
Sarwinska, D., Grimm, M. F., Krause, J., Schick, P., Gollasch, M., Mannaa, M., Ritter, C. A., & Weitschies, W. (2024) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2024.106814 · Cited by 10 · see citing works
Safety and Efficacy of TKIs in very Elderly Patients (≥75 Years) with Chronic Myeloid Leukemia
Costa, A. N., Abruzzese, E., Latagliata, R., Mulas, O., Carmosino, I., Scalzulli, E., Bisegna, M. L., Ielo, C., Martelli, M., Caocci, G., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13010273 · Cited by 10 · see citing works
Alexandrino, A., de Oliveira, C. B. S., Gomes, S. M., Nogueira, M. F., Mendes, T. C. D. O., & de Lima, K. C. (2023) · Revista Brasileira de Geriatria e Gerontologia · doi:10.1590/1981-22562023026.230105.pt · Cited by 9 · see citing works
Zerriouh, M., Clifford‐Faugère, G. D., Nguefack, H. L. N., Pagé, M. G., Guénette, L., Blais, L., & Lacasse, A. (2024) · Frontiers in Pain Research · doi:10.3389/fpain.2024.1306479 · Cited by 9 · see citing works
Understanding polypharmacy for people receiving home care services: a scoping review of the evidence
Karimi, R., Robinson, A., Davey, V., Sinclair, D. R., Hanratty, B., & Todd, A. (2025) · Age and Ageing · doi:10.1093/ageing/afaf031 · Cited by 8 · see citing works
Ghezeljeh, T. N., Kohne, Z. A. M., Farahani, M. A., Rafii, F., & Shahrestanaki, S. K. (2025) · BMC Nursing · doi:10.1186/s12912-024-02675-5 · Cited by 7 · see citing works
Chronic Pain Management in an Aging Population: Current Challenges and Policy-Based Solutions
LaRowe, L. R., Patidar, S. M., Goetzinger, A. M., Margolies, S. O., & Mace, R. A. (2024) · Policy Insights from the Behavioral and Brain Sciences · doi:10.1177/23727322241307916 · Cited by 7 · see citing works
Bjune, T., Bøe, T. B., Kjellevold, S. A., Heldal, K., & Abedini, S. (2023) · International Journal of Nephrology and Renovascular Disease · doi:10.2147/ijnrd.s401623 · Cited by 6 · see citing works
Editorial: Chronic Pain and Health Disparities in Older Adults With Complex Needs
Karris, M., & Danilovich, M. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.941476 · Cited by 6 · see citing works
Clifford‐Faugère, G. D., Lacasse, A., Nguefack, H. L. N., Godbout-Parent, M., Boulanger, A., & Julien, N. (2025) · BMC Family Practice · doi:10.1186/s12875-025-02704-5 · Cited by 5 · see citing works
Fan, Y.-P., Lai, T.-H., Lai, J., & Yang, C. (2024) · Geriatric Nursing · doi:10.1016/j.gerinurse.2024.04.024 · Cited by 5 · see citing works
Rasch analysis of the Depression, Anxiety, and Stress Scale in patients with chronic pain
Abberger, B., & Kieselbach, K. (2024) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2024.111597 · Cited by 4 · see citing works
Kokorelias, K. M., Singh, H. K., Abdelhalim, R., Saragosa, M., Fat, G. L., & Sheppard, C. L. (2023) · PLoS ONE · doi:10.1371/journal.pone.0291252 · Cited by 4 · see citing works
Nijs, J., Ahmed, I., Vandeputte, D., Goodin, B. R., Adetayo, T., Kindt, S., Vanroose, M., Elma, Ö., Johansson, E., Logghe, T., et al. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14248812 · Cited by 3 · see citing works
Bibliometric and visual analysis of medication therapy management from 2003 to 2023
Guo, Z., Fu, L., Chu, Z., Gao, S., Lu, L., & Jiao, W. (2024) · Medicine · doi:10.1097/md.0000000000040953 · Cited by 3 · see citing works
Clifford‐Faugère, G. D., Nguefack, H. L. N., Ménard, N., Beaudoin, S., Pagé, M. G., Guénette, L., Hudon, C., Samb, O. M., & Lacasse, A. (2025) · Frontiers in Pain Research · doi:10.3389/fpain.2025.1512878 · Cited by 3 · see citing works
Kaier, K., Brühmann, B. A., Fetzer, S., von der Warth, R., & Farin‐Glattacker, E. (2024) · BMC Health Services Research · doi:10.1186/s12913-024-10635-7 · Cited by 3 · see citing works
Implementation of pharmacotherapy monitoring: Experiences and views of medicine users
Rönngård‐Jalkanen, A., Saastamoinen, L., Aarnio, E., & Timonen, J. (2023) · Exploratory Research in Clinical and Social Pharmacy · doi:10.1016/j.rcsop.2023.100377 · Cited by 3 · see citing works
Hypertension in older patients: a STEP forward?
Bénétos, A., Persu, A., & Kreutz, R. H. (2022) · Blood Pressure · doi:10.1080/08037051.2022.2075826 · Cited by 3 · see citing works
Self-citationLanducci, G., Gustafson, D. H., Sr., Mares, M., Pe‐Romashko, K., Curtin, J. J., Hu, Y., Maus, A., Thompson, K., Saunders, S., Brown, K., et al. (2025) · JMIR Aging · doi:10.2196/75991 · Cited by 2 · see citing works
Rose, A., Muthukumarasamy, K. M., Dasari, H., Gaudreau, P., & Hiram, R. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103266 · Cited by 2 · see citing works
Shaping the future of geriatric chronic pain care: a research agenda for progress
LaRowe, L. R., Pham, T. V., Szapary, C. L., & Vranceanu, A. (2025) · Pain Management · doi:10.1080/17581869.2025.2493609 · Cited by 2 · see citing works
Li, H., & Cheng, C. (2025) · Journal of Community Health Nursing · doi:10.1080/07370016.2025.2477446 · Cited by 2 · see citing works
Signal detection of adverse events associated with gabapentinoid use for chronic pain
Kuo, Y., Polychronopoulou, E., & Raji, M. A. (2023) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.5685 · Cited by 1 · see citing works
Prieto, L. (2024) · Life · doi:10.3390/life14020184 · Cited by 1 · see citing works
Ståhl, S., af Geijerstam, P., Wijkman, M. O., Johansson, M. M., Chalmers, J. P., Nägga, K., & Rådholm, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-94913-2 · Cited by 1 · see citing works
Peltner, J., Degen, M., Ebert, N., Fischer, B., Guenther, K., Harries, M., Harth, V., Haug, U., Heier, M., Karch, A., et al. (2026) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.m2026.0096 · Cited by 1 · see citing works
Horn, D. B., Shukla, A. P., Huang, H., Twum, E. A., Allen, S. E., & Kiš, S. G. (2026) · Obesity Pillars · doi:10.1016/j.obpill.2026.100301 · Cited by 1 · see citing works
Pain: the use of paracetamol in multimorbid patients
Salamone, F. (2022) · Medical Academy Journal · doi:10.56823/olpu5844 · Cited by 1 · see citing works
Pharmacist ambulatory pain services for a chronic non‐cancer pain clinic: a descriptive study
Maleki, S., Szmerling, J. D., Thiruvasagan, M., Seah, G. J., & Gu, G. (2023) · Journal of Pharmacy Practice and Research · doi:10.1002/jppr.1875 · Cited by 1 · see citing works
la Cerna‐Luna, R. D., Fernandez‐Guzman, D., Machicado-Chipana, I., Martinez-Zapata, V., Serna-Chavez, P., & Paz-Cuellar, K. (2024) · International Journal of Rehabilitation Research · doi:10.1097/mrr.0000000000000630 · Cited by 1 · see citing works
Tipos e causas de erros de uso de medicamentos em serviços hospitalares de emergência:
Bendinelli, P. D. C., & Tomaz, S. L. (2024) · JBMEDE - Jornal Brasileiro de Medicina de Emergência · doi:10.54143/jbmede.v3i4.67 · Cited by 1 · see citing works
Umar, T. P., Tanasov, A., Stevanny, B., Agustini, D., Dave, T., Nabhan, A. I., Madany, M., Ibrahim, M., Nguyen, D. H., Jain, S., et al. (2023) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/979-8-3693-0260-6.ch001 · Cited by 1 · see citing works
Approach to hypertension in geriatric population
Felek, D., & Çi̇fci̇, A. (2023) · Journal of Cardiology & Cardiovascular Surgery · doi:10.51271/jccvs-0013
Prevalence of multimorbidity and associated factors among older people in rural Northeast Brazil
Alexandrino, A., de Oliveira, C. B. S., Gomes, S. M., Nogueira, M. F., Mendes, T. C. D. O., & de Lima, K. C. (2023) · Revista Brasileira de Geriatria e Gerontologia · doi:10.1590/1981-22562023026.230105.en
Dolor neuropático localizado: A propósito de un caso de neuralgia posherpética
Sierra, P. B., & Sánchez, M. (2023) · Bionatura · doi:10.21931/rb/2023.08.04.17
A Study On Drug-Drug Interactions Among Hospitalized Patients At Private Hospital
Suthar, J. V., & Patel, J. (2024) · doi:10.53555/kuey.v30i2.1554
Medicamentos Potencialmente Inapropriados: Um estudo no Programa Cidade do Idoso
Farias, K. C., Roza, F., Meneghetti, M. V. V., Lopes, M. C. B., Zancanaro, M., Züge, S. S., Lindman, H., Kuovacki, F. F., Laides, J. B., Mânica, A., et al. (2025) · Revista FisiSenectus · doi:10.22298/rfs.2025.v13.n1.8286
Natarajan, A., & Kumar, B. K. (2025) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20253178
Alam, S. Z. Z., & Akkawi, M. E. (2025) · Geriatric Pharmacology · doi:10.1080/2994399x.2025.2560306
Bidirectional relationships between pain and alcohol use among older adults: a scoping review
LaRowe, L. R., Granados, H. C., Philpotts, L. L., Vranceanu, A., & Ritchie, C. S. (2025) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaf258
Kaier, K., Brühmann, B. A., Fetzer, S., von der Warth, R., & Farin-Glattacker, E. (2024) · Figshare · doi:10.6084/m9.figshare.25223428
Pedersen, J. R., Pedersen, A. K., Eltved, R., Jensen, P. F., Sabrido, I., Hedegaard, M., Blichfeldt‐Eckhardt, M. R., Hansson, S. H., & Vægter, H. B. (2026) · European Journal of Pain · doi:10.1002/ejp.70217
Dewi, R. M., Septiana, L., Diki Aprianto, A., Mildawati, R., & Fatmawati, E. N. (2025) · Fundamental and Applied Research in Medicine and Allied Sciences Indonesia · doi:10.69855/farmasi.v1i1.387
Bates, N., Huerta, P. L., Carraway, M., Zimmerman, J., Tumin, D., & Ryan, D. P. (2026) · Drugs & Aging · doi:10.1007/s40266-026-01289-7
Chronic pain and multimorbidity
Shirinsky, V. S., & Shirinsky, I. V. (2026) · Russian Journal of Pain · doi:10.17116/pain20262401172
Age Differences in Pain-Related Variables Among Individuals with Chronic Pain
Adachi, T., Enomoto, K., Barrett, T. D., Nakanishi, M., Iwashita, N., & Kitagawa, H. (2026) · GeroPsych · doi:10.1024/1662-9647/a000363
Conceptualizing and treating the polytrauma clinical triad as a complex chronic pain syndrome
Manhapra, A., Kennedy, E., Cifu, D. X., Miles, S. R., & Pugh, M. J. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1752206
Akute Extremitätenischämie im hohen Lebensalter
Passaloglou, I. T. (2026) · Springer eBooks · doi:10.1007/978-3-662-71191-0_13
Nakayama, G., Masumoto, S., Sun, Y., Ishii, M., Nin, S., Inaba, T., Kajikawa, N., Hamada, S., Kimura, N., & Hamano, J. (2026) · Journal of General and Family Medicine · doi:10.1002/jgf2.70170
Maharani, L., Rahmawati, F., Ikawati, Z., & Mustofa (2026) · The Indonesian Journal of Public Health · doi:10.20473/ijph.v21i2.2026.352-366
Tsarfati, B., Manor-Binyamini, I., & Shinan‐Altman, S. (2026) · Healthcare · doi:10.3390/healthcare14203365
Advances in research on combination therapy for the management of pain
Gilron, I., & Peterson, C. (2026) · Pain · doi:10.1097/j.pain.0000000000004046
- Authors
- Schneider, J., Algharably, E. A. E., Budnick, A., Wenzel, A., Dräger, D., & Kreutz, R.
- Affiliations
- Humboldt-Universität zu Berlin (DE)
- Corresponding author
- Kreutz, Reinhold
- ORCID
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2021-06-08
- Volume
- 12
- Pages
- 686990-686990
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC8217758
- OpenAlex
- W3169409521
- Cited by
- 70
- References
- 47
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 21 · 2023: 17 · 2022: 7 · 2021: 1
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Refubium (Universitätsbibliothek der Freien Universität Berlin) (submittedVersion, cc-by)
- Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver (cc-by)
- Funders
- Deutsche Forschungsgemeinschaft
- Helmholtz Zentrum München
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- multimorbidity, polypharmacy, chronic pain, elderly patients, home care, drug-related problems, drug interactions, overprescribing, underprescribing, oral anticoagulants, atrial fibrillation, loop diuretics, self-medication, Charlson Comorbidity Index
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