CoChat
Sign Up
Cited by 132Herpesvirus Infections and TreatmentsDrug-Induced Adverse ReactionsCytomegalovirus and herpesvirus research

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Nonsteroidal anti‐inflammatory drug use and the risk of severe skin and soft tissue complications in patients with varicella or zoster disease

Open access
Mikaeloff, Yann, Kezouh, Abbas, Suissa, Samy·2008·British Journal of Clinical Pharmacology
DOI 10.1111/j.1365-2125.2007.02997.xPMC PMC2291221
Open this paper in CoChat — free accountOpen PDF

Abstract

What is already known about this subject • Three previous epidemiological studies found an increased risk of severe skin and soft tissue infectious complications associated with exposure to NSAIDs in children with varicella. • In vitro studies demonstrated that decreases in defences against infections induced by NSAIDs could be due to impairment of neutrophil blood cell function. What this study adds • The use of NSAIDs is associated with an increased risk of severe skin and soft tissue complication of varicella in children. • The use of NSAIDs is also associated with a small increased risk of such complications in zoster disease in adults and the elderly. • This study supports the limited prescription of NSAIDs in VZV infection. Aims To assess the risk of severe skin and soft tissue complications associated with the use of nonsteroidal anti‐inflammatory drugs (NSAIDs) in treating patients with varicella zoster virus infection. Methods The design was a nested case‐control study, with matching for age and practice. The setting was primary care in the United Kingdom (United Kingdom's General Practice Research Database). Two population‐based cohorts of all patients with a primary varicella (n = 140 111) or zoster (n = 108 257) diagnosis during 1994–2005 were followed up for 2 months after diagnosis. Main outcome measures of severe skin or soft tissue complications (mostly cellulitis and abscess) associated with current NSAID or paracetamol use were estimated, and adjusted for potential confounding factors, including sex, drug use, and comorbidity. Results In patients with varicella, there were 386 cases of severe skin or soft tissue complications (rate 2.8 per 1000) during the 2 month follow‐up period (mean age 10.7 years). The rate of complications associated with exposure to NSAIDs was increased (rate ratio 4.9; 95% CI 2.1, 11.4). In patients with zoster disease, there were 681 cases of severe skin or soft tissue complications (rate 6.3 per 1000) during the 2 month follow‐up (mean age 60.9 years). The rate ratio of complications associated with exposure to NSAIDs was 1.6 (95% CI 1.1, 2.4). In both conditions, there was no increased risk of complication associated with a current exposure to paracetamol. Conclusions The use of NSAIDs is associated with an elevated risk of severe skin and soft tissue complications of varicella zoster virus infection, mostly in children with varicella.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/j.1365-2125.2007.02997.x

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 37 references

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Mikaeloff, Y., Kezouh, A., & Suissa, S.
Affiliations
  • Assistance Publique – Hôpitaux de Paris (FR)
  • McGill University (CA)
Corresponding author
Suissa, Samy
ORCID
Venue
British Journal of Clinical Pharmacology
Publisher
Wiley
Published
2007-08-15
Volume
65
Issue
2
Pages
203-209
ISSN
  • 0306-5251 (ISSN-L)
  • 1365-2125
DOI
10.1111/j.1365-2125.2007.02997.x
PMC
PMC2291221
OpenAlex
W2016022909
Cited by
132
References
37
Citations by year
2026: 6 · 2025: 9 · 2024: 9 · 2023: 3 · 2022: 8 · 2021: 13 · 2020: 7 · 2019: 7 · 2018: 5 · 2017: 10 · 2016: 11 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 3
FWCI
4.13
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • British Journal of Clinical Pharmacology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
  • Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
  • Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Keywords
nonsteroidal anti-inflammatory drugs, varicella, herpes zoster, varicella-zoster virus infection, cellulitis, abscess, paracetamol, NSAID adverse effects, children, older adults, neutrophil function, infection risk, primary care patients, Clinical Practice Research Datalink, nested case-control study, confounding
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal, Chickenpox, Child, Female, Follow-Up Studies, Herpes Zoster, Humans, Male, Middle Aged, Risk Factors, Cohort Studies, Case-Control Studies, Skin Diseases, Viral, Soft Tissue Infections

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review