Thin-layer chromatography of phospholipid components of normal and psoriatic epidermis
Abstract
The phospholipid pattern of human epidermis from 23 psoriatic patients and from 14 healthy individuals has been determined using lipid thin-layer chromatography. An increased amount of total phospholipids and statistically significant differences in some phospholipid components were found in psoriatic patients as compared to healthy controls. These abnormalities may be related to the altered architecture of the plasma membranes and their surface coats observed in psoriatic keratinocytes.
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An increase in the levels of phospholipids, triacylglycerols, and cholesterol was found in the epidermis of psoriatic patients, which correlated with the severity of psoriasis.
“However, an increase in the levels of phospholipids, triacylglycerols, and cholesterol were found in the epidermis of psoriatic patients, which correlated with the severity of psoriasis.36–38”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [38]
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Lipid composition and metabolism in normal and diseased epidermis
Yardley, H. J., & Summerly, R. (1981) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(81)90006-1 · Cited by 267 · see citing works
Sebaceous-immunobiology is orchestrated by sebum lipids
Lovászi, M., Szegedi, A., Zouboulis, C. C., & Törőcsik, D. (2017) · Dermato-Endocrinology · doi:10.1080/19381980.2017.1375636 · Cited by 151 · see citing works
- Authors
- TSAMBAOS, D., KALOFOUTIS, A., STRATIGOS, J., MIRAS, C., & CAPETANAKIS, J.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- ORCID
- TSAMBAOS, D.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 1977-08
- Volume
- 97
- Issue
- 2
- Pages
- 135-138
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- OpenAlex
- W2025139143
- Cited by
- 25
- References
- 0
- Citations by year
- 2021: 2 · 2019: 1 · 2017: 1
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- psoriasis, epidermis, phospholipids, plasma membrane, keratinocytes, membrane lipid composition, skin lipids
- MeSH terms
- Cell Membrane, Chromatography, Thin Layer, Epidermis, Female, Humans, Male, Membrane Lipids, Phospholipids, Psoriasis
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