Lipid composition and metabolism in normal and diseased epidermis

Yardley, H.J.; Summerly, R.

doi:10.1016/0163-7258(81)90006-1

Cited by 267Lipid metabolism and biosynthesisAdvancements in Transdermal Drug DeliveryDermatology and Skin Diseases

Lipid composition and metabolism in normal and diseased epidermis

Yardley, H.J., Summerly, R.·1981·Pharmacology & Therapeutics

DOI 10.1016/0163-7258(81)90006-1

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Ceramides account for approximately 50% by weight of the main constituents of lipid lamellae in the stratum corneum.
“The main constituents of lipid lamellae are ceramides, cholesterol, and FFAs, of which ceramides account for 50% by weight (4).”
From Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS (2020) · cites this paper as [4]

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Wp, A., Rk, W., & PERRY, H. O. (1961) · PubMed · Cited by 38 · see citing works
Epidermal lipid metabolism in psoriasis and lichen simplex
Cooper, M. F., McGRATH, H., & Shuster, S. (1976) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1976.tb06114.x · Cited by 37 · see citing works
FATTY-ACID-RESPONSIVE ALOPECIA IN MULTIPLE CARBOXYLASE DEFICIENCY
Münnich, A., Saudubray, J., Coudé, F. X., Charpentier, C., Saurat, J. ‐., & Frézal, J. (1980) · The Lancet · doi:10.1016/s0140-6736(80)91518-4 · Cited by 35 · see citing works
The Phospholipases A of Epidermis
Freinkel, R. K., & Traczyk, T. N. (1980) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12535073 · Cited by 35 · see citing works
ESSENTIAL FATTY ACIDS AND PROSTAGLANDINS
van Dorp, D. A. (1974) · Elsevier eBooks · doi:10.1016/b978-0-408-70577-6.50009-8 · Cited by 34 · see citing works
THE IN VITRO INCORPORATION OF 14C-ACETATE INTO THE ISOLATED SEBACEOUS GLANDS AND APPENDAGE-FREED EPIDERMIS OF HUMAN SKIN.
Summerly, R., & Woodbury, S. (1971) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1971.tb14048.x · Cited by 34 · see citing works
Self-citation
Biosynthesis of Skin Sterols
Gaylor, J. L. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51654-9 · Cited by 34 · see citing works
An Electron Microscopic Study of the Effects of Subtilisin and Detergents on Human Stratum Corneum**From The Procter and Gamble Company Research Division. Miami Valley Laboratories, Cincinnati. Ohio 45239
Loomans, M. E., & Hannon, D. P. (1970) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12291544 · Cited by 32 · see citing works
Phospholipids in Cultured Guinea Pig Skin
Long, V., & Yardley, H. J. (1970) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12258437 · Cited by 32 · see citing works
Self-citation
Biosynthesis of Skin Sterols
Gaylor, J. L. (1963) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81116-4 · Cited by 32 · see citing works
Linoleic Acid Effects on Epidermal DNA Synthesis and Cutaneous Prostaglandin Levels in Essential Fatty Acid Deficiency
Lowe, N. J., & DeQuoy, P. R. (1978) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12541324 · Cited by 31 · see citing works
STEEOLS AND KEKATINIZATION*
Yardley, H. J. (1969) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1969.tb12843.x · Cited by 31 · see citing works
Self-citation
Myotonia and Keratoderma Induced by 20,25 Diazacholestenol
Anderson, P. C. (1965) · Archives of Dermatology · doi:10.1001/archderm.1965.01600140069018 · Cited by 31 · see citing works
Epidermal Lipid Liposomes: A Novel Non-Phospholipid Membrane System
GRAY, G. M., & White, R. J. (1979) · Biochemical Society Transactions · doi:10.1042/bst0071129 · Cited by 31 · see citing works
DEFECTIVE PROSTAGLANDIN SYNTHESIS IN ACRODERMATITIS ENTEROPATHICA
Evans, G., & Johnson, P. E. (1977) · The Lancet · doi:10.1016/s0140-6736(77)91695-6 · Cited by 30 · see citing works
Localization and biosynthesis of 7-dehydrocholesterol in rat skin
Gaylor, J. L., & Sault, F. M. (1964) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40216-0 · Cited by 30 · see citing works
Synthesis of lipids from acetate by human preputial and abdominal skin in vitro
Vroman, H. E., Nemecek, R. A., & Hsia, S. L. (1969) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43042-1 · Cited by 29 · see citing works
Reversal of experimental essential fatty acid deficiency by cutaneous administration of safflower oil
Böhles, H. J., Bieber, M. A., & Heird, W. (1976) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/29.4.398 · Cited by 29 · see citing works
The Plasma Membrane of Granular Cells from Pig Epidermis: Isolation and Lipid and Protein Composition
Gray, G. M., King, I. A., & Yardley, H. J. (1978) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12546728 · Cited by 29 · see citing works
Self-citation
Cutaneous Lipogenesis I. Evaluation Of Model Systems and the Utilization of Acetate, Citrate and Glucose as Compared with other Tissues
Wheatley, V. R., Hodgins, L. T., & Coon, W. M. (1970) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12258582 · Cited by 29 · see citing works
Enzymic formation of esters of methyl sterol precursors of cholesterol
Brady, D. R., & Gaylor, J. L. (1971) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39506-7 · Cited by 29 · see citing works
Esterification Of [4-14c]Cholesterol by Cutaneous Bacteria (Staphylococcus Epidermidis, Propionibacterium Acnes, and Propionibacterium Granulosum)
Puhvel, S. M. (1975) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12512331 · Cited by 28 · see citing works
Identification of vitamin D3 in human skin.
Rauschkolb, E. W., Davis, H. W., Fenimore, D. C., Black, H. S., & Fabre, L. F. (1969) · PubMed · Cited by 28 · see citing works
Esterification of Cholesterol in the Skin**From the Department of Dermatology, Northwestern Medical School, 303 East Chicago Avenue, Chicago, Illinois, 60611.
Freinkel, R. K., & Aso, K. (1969) · Journal of Investigative Dermatology · doi:10.1038/jid.1969.22 · Cited by 27 · see citing works
Studies of the Lipids of Dog Skin
Wheatley, V. R., Chow, D. C., & Keenan, F. D. (1961) · Journal of Investigative Dermatology · doi:10.1038/jid.1961.40 · Cited by 26 · see citing works
Identification of Vitamin D3 in Human Skin**From the Veterans Administration Hospital, Department of Dermatology, Baylor College of Medicine, and Texas Research Institute of Mental Sciences, Houston, Texas.
Rauschkolb, E. W., Davis, H. W., Fenimore, D. C., Black, H. S., & Fabre, L. F. (1969) · Journal of Investigative Dermatology · doi:10.1038/jid.1969.149 · Cited by 26 · see citing works
The effects of essential fatty acid deficiency on the fine structure of mouse skin
Menton, D. N. (1970) · Journal of Morphology · doi:10.1002/jmor.1051320206 · Cited by 25 · see citing works
Thin-layer chromatography of phospholipid components of normal and psoriatic epidermis
TSAMBAOS, D., KALOFOUTIS, A., STRATIGOS, J., MIRAS, C., & CAPETANAKIS, J. (1977) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1977.tb15058.x · Cited by 25 · see citing works
Chylous Ascites and Lymphedema
Warwick, W. J. (1959) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1959.02070020319005 · Cited by 25 · see citing works
Changes in dry weight and projected area of human epidermal cells undergoing keratinization as determined by scanning interference microscopy
Yardley, H. J., & GOLDSTEIN, D. J. (1976) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1976.tb07034.x · Cited by 25 · see citing works
Self-citation
Acrodermatitis enteropathico. Abnormalities of fat metabolism and integumental ultrastructures in infants
Ginsburg, R. (1976) · Archives of Dermatology · doi:10.1001/archderm.112.5.653 · Cited by 25 · see citing works
Cutaneous lipogenesis: precursors utilized by guinea pig skin for lipid synthesis
Wheatley, V. R., Hodgins, L. T., Coon, W. M., Kumarasiri, M., Berenzweig, H., & Feinstein, J. M. (1971) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39516-x · Cited by 24 · see citing works
Lipogenesis in Human Skin11From the Department of Medicine, New England Center Hospital, and Tufts University School of Medicine, Boston 11, Massachusetts
Patterson, J. F., & Griesemer, R. D. (1959) · Journal of Investigative Dermatology · doi:10.1038/jid.1959.151 · Cited by 24 · see citing works
Isolation of a Glycoproteolipid from Human Horny Layers**From the Department of Dermatology, University of Pennsylvania, School of Medicine, Philadelphia 4, Pennsylvania.
Flesch, P., & Esoda, E. C. J. (1962) · Journal of Investigative Dermatology · doi:10.1038/jid.1962.132 · Cited by 24 · see citing works
Metabolic Studies on Skin
Brooks, S. C., Godefroi, V. C., & Simpson, W. L. (1963) · Journal of Investigative Dermatology · doi:10.1038/jid.1963.154 · Cited by 23 · see citing works
Acetate metabolism: Effects of tracer concentration
Emerson, R. J., & Bruggen, J. T. V. (1958) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(58)90093-6 · Cited by 23 · see citing works
CHOLESTREOL SYNTHESIS IN ICHTHYOSIS VULGARIS
and, R. S., & Yardley, H. J. (1967) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1967.tb11515.x · Cited by 22 · see citing works
Self-citation
Biosynthesis of Skin Sterols
Gaylor, J. L. (1963) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81115-2 · Cited by 22 · see citing works
STUDIES ON THE REGULATION OF CHOLESTEROL SYNTHESIS IN THE SKIN AND PREPUTIAL GLAND OF THE RAT
Wilson, J. D. (1963) · Elsevier eBooks · doi:10.1016/b978-0-08-009945-3.50014-5 · Cited by 22 · see citing works
Esterification of Sterols During Differentiation and Cornification of Developing Rat Epidermis
Freinkel, R. K., & Fiedler‐Weiss, V. C. (1974) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12701701 · Cited by 21 · see citing works
The plasma membrane of Malpighian cells from pig epidermis: isolation and lipid and protein composition
GRAY, G. M., King, I. A., & Yardley, H. J. (1980) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1980.tb01665.x · Cited by 21 · see citing works
Self-citation
Lipogenesis in Epidermal Differentiation of Embryonic Chicken Skin
Freinkel, R. K. (1972) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12627389 · Cited by 21 · see citing works
Lipogenesis in rat skin: A possible regulatory role of glycerol 3-phosphate
Ziboh, V. A., & Hsia, S. L. (1969) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(69)90115-5 · Cited by 21 · see citing works
Comparison of barrier function and lipids in psoriasis and essential fatty acid-deficient rats
Hartop, P. J., Allenby, C. F., & Prottey, C. (1978) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.1978.tb01497.x · Cited by 20 · see citing works
Mitochondria and Nuclei of Pig and Human Epidermis: Isolation and Lipid Composition
Gray, G. M., & Yardley, H. J. (1975) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12512400 · Cited by 20 · see citing works
Self-citation
Lipid Synthesis from Acetate-1-14C by Suction Blister Epidermis and Other Skin Components
Hsia, S. L., Fulton, J. E., Fulghum, D. D., & Buch, M. M. (1970) · Experimental Biology and Medicine · doi:10.3181/00379727-135-35037 · Cited by 20 · see citing works
Keratinization in Historical Perspective
Rothman, S. S. (1964) · Elsevier eBooks · doi:10.1016/b978-1-4832-3293-5.50007-3 · Cited by 20 · see citing works
Incorporation of Acetate-1-C14 into Fatty Acids of Isolated Epidermal Cells
Wilkinson, D. I. (1970) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12257158 · Cited by 20 · see citing works
Hormonal regulation of cutaneous lipogenesis: Effects of hypophysectomy, posterior-hypophysectomy and α-melanocyte-stimulating hormone treatment
Cooper, M. F., Thody, A. J., & Shuster, S. (1974) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(74)90169-6 · Cited by 19 · see citing works
Ultrastructural Features of Ichthyotic Skin in Refsum’s Syndrome
Blanchet‐Bardon, C., Anton‐Lamprecht, I., Puissant, A., & Schnyder, U. W. (1978) · Springer eBooks · doi:10.1007/978-94-010-9851-9_9 · Cited by 19 · see citing works
Biosynthesis of skin sterols. II. Reduction of Δ24-unsaturated sterols of rat skin
Gaylor, J. L. (1963) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(63)90541-1 · Cited by 19 · see citing works
The phospholipid pattern in the involved and the uninvolved psoriatic epidermis
Tsambaos, D., & Mahrle, G. (1979) · Archives of Dermatological Research · doi:10.1007/bf00694626 · Cited by 19 · see citing works
Lipogenesis in Human Skin. III. Variation with Body Site
Griesemer, R. D., & Thomas, R. W. (1963) · Journal of Investigative Dermatology · doi:10.1038/jid.1963.101 · Cited by 19 · see citing works
Inhibition of prostaglandin biosynthesis by c−5, c−8, c−11-eicosatrienoic acid
van Evert, W. C., Nugteren, D. H., & van Dorp, D. A. (1978) · Prostaglandins · doi:10.1016/0090-6980(78)90165-x · Cited by 19 · see citing works
ESSENTIAL FATTY ACIDS AND THE SKIN
Sinclair, H. M. (1958) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a069693 · Cited by 18 · see citing works
Sex-linked ichthyosis and placental sulphatase C deficiency
de Groot, W. P., Jöbsis, A. C., Ilsen, A., Koppe, J. G., & de Bruijn, H. W. A. (1980) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1980.tb15840.x · Cited by 17 · see citing works
Phospholipase A Activity in the Epidermis
Long, V., & Yardley, H. J. (1972) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12538971 · Cited by 17 · see citing works
Self-citation
Studies on the biogenesis of vitamin D. I. Identification and determination of 7-dehydrocholesterol in rat skin.
YASUMURA, M., Okano, T., MIZUNO, K., & Kobayashi, T. (1977) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.23.513 · Cited by 17 · see citing works
Lipogenesis from amino acids in perfused isolated dog skin
Wheatley, V. R., Lipkin, G., & Woo, T. H. (1967) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38919-7 · Cited by 17 · see citing works
Some in vitro effects of hypoglycin on skin.
Yardley, H. J., & Godfrey, G. (1967) · PubMed · Cited by 16 · see citing works
Self-citation
Sequence of Histologic Changes in Skin of Dogs in Relation to Dietary Fat
Hansen, A. E., Sinclair, J. G., & Wiese, H. F. (1954) · Journal of Nutrition · doi:10.1093/jn/52.4.541 · Cited by 16 · see citing works
Mitotic Activity in the Skin of Mice Deficient in Essential Fatty Acids
NASR, A. N., & Shostak, S. (1965) · Nature · doi:10.1038/2071395a0 · Cited by 15 · see citing works
Biosynthesis of skin sterols. V. Effect of arsenite inhibition and the accumulation of labeled lanosta-7,24-dien-3β-ol in rat skin
Gaylor, J. L. (1963) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(63)90495-8 · Cited by 15 · see citing works
Changes in Glycerolipid Metabolism in Rat Epidermis Following Exaggerated Washing with Soap Solutions
Prottey, C., & Hartop, P. J. (1973) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12676222 · Cited by 15 · see citing works
Possible defects in triacylglycerol and phosphatidyl- choline metabolism in psoriatic epidermis
Summerly, R., ILDERTON, E., & GRAY, G. M. (1978) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1978.tb01997.x · Cited by 15 · see citing works
Self-citation
Enzymes of Sterol Biosynthesis
Gaylor, J. L. (1974) · Elsevier eBooks · doi:10.1016/b978-0-8391-1043-9.50007-9 · Cited by 14 · see citing works
Esterification of cholesterol by epidermis
Freinkel, R. K., & Aso, K. (1971) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(71)90198-6 · Cited by 14 · see citing works
FLUX OF FATTY ACIDS DURING EPIDERMAL DIFFERENTIATION
Freinkel, R. K., & Traczyk, T. N. (1977) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12510328 · Cited by 14 · see citing works
In Vivo Chemotaxis Induced by Polyunsaturated Fatty Acids
Penneys, N. S., Simon, P., Ziboh, V. A., & Schlossberg, J. (1977) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12510727 · Cited by 14 · see citing works
LIPID SYNTHESIS IN RAT SKIN
PROTTEY, G., Hartop, P. J., & Ferguson, T. F. M. (1972) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1972.tb07450.x · Cited by 14 · see citing works
Phospholipase A and Lysophospholipase activity of the epidermis
Long, V. (1975) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1975.tb03138.x · Cited by 14 · see citing works
Fatty acid composition of tissues in Refsum's disease (herodopathia atactica polyneuritiformis). Estimation of total phytanic acid accumulation.
Cl, M., Jonniaux, G., Voet, W., & Bergen, C. J. V. D. (1974) · PubMed · Cited by 14 · see citing works
The fatty acid composition of dermal and epidermal triglycerides and phosphatides in mouse skin during normal and abnormal growth.
Carruthers, C. (1962) · PubMed · Cited by 13 · see citing works
Polyunsaturated fatty acids of skin; Identification and14C‐Acetate incorporation
Wilkinson, D. I. (1972) · Lipids · doi:10.1007/bf02533021 · Cited by 13 · see citing works
Preparation and properties of a cell-free system from rat skin that catalyzes sterol biosynthesis
Gaylor, J. L., Delwiche, C. V., Brady, D. R., & Green, A. J. (1966) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39260-9 · Cited by 13 · see citing works
Compositional differences of lipid in transformed hamster fibroblasts
Fu-Chang, C., Eng, L. F., & Griffin, A. (1972) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(72)90032-x · Cited by 12 · see citing works
Lipid Metabolism in Human Skin I. Lipogenesis from Acetate-1-14C*
Hsia, S. L., Sofer, G., & Lane, B. (1966) · Journal of Investigative Dermatology · doi:10.1038/jid.1966.166 · Cited by 11 · see citing works
Incorporation of i-14C-acetate into the lipids of isolated epidermal cells
Long, V. (1976) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1976.tb04380.x · Cited by 10 · see citing works
Proliferative epidermis of essential fatty acid deficient mice has reduced cyclic AMP content
Lowe, N. J., DUELL, E., & Voorhees, J. J. (1979) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1979.tb15289.x · Cited by 9 · see citing works
MEASUREMENT OF LIPID SYNTHESIS IN MOUSE AURICULAR SKIN CULTURED IN VITRO
Prottey, C., & Ferguson, T. F. M. (1972) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1972.tb01596.x · Cited by 9 · see citing works
Studies of the Lipids of Dog Skin III
Lipkin, G., Wheatley, V. R., & March, C. H. (1965) · Journal of Investigative Dermatology · doi:10.1038/jid.1965.142 · Cited by 9 · see citing works
Lipogenesis in Human Skin. IV. In Vitro Rate Studies*
Griesemer, R. D., & Thomas, R. W. (1966) · Journal of Investigative Dermatology · doi:10.1038/jid.1966.165 · Cited by 8 · see citing works
Lipogenesis During Cornification of Chicken Skin in Organ Culture
Freinkel, R. K. (1972) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12627395 · Cited by 8 · see citing works
The Role of Fatty Acid Oxidation in The Epidermis
Anastasia, J. V., & Conley, J. P. (1977) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12510725 · Cited by 8 · see citing works
Essential fatty acid supplementation inhibits the effect of dietary zinc deficiency.
Cunnane, S. C., Ge, S., & Horrobin, D. F. (1980) · PubMed · Cited by 8 · see citing works
Chemical Anomalies in Pathological Horny Layers
Flesch, P., & Esoda, E. C. J. (1964) · Elsevier eBooks · doi:10.1016/b978-1-4832-3293-5.50034-6 · Cited by 8 · see citing works
Demonstration of �-lipoproteins in the psoriatic skin by immunofluorescent technique
Ishikawa, H., & Sato, H. (1974) · Archives of Dermatological Research · doi:10.1007/bf00604821 · Cited by 7 · see citing works
Sterol synthesis: studies of the metabolism of 14 alpha-methyl-5 alpha-cholest-7-en-3 beta-ol.
Chan, J. T., Spike, T. E., Trowbridge, S. T., & Schroepfer, G. J. (1979) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40003-3 · Cited by 7 · see citing works
THE EFFECTS OF SOME COMPOUNDS ON THE ENDOGENOUS RESPIRATION OF SKIN
Long, V., & Yardley, H. J. (1971) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1971.tb07204.x · Cited by 6 · see citing works
Self-citation
The origin of lanosta-7,24-dienol in rat skin
Hornby, G. M., & Boyd, G. S. (1971) · Biochemical Journal · doi:10.1042/bj1240831 · Cited by 6 · see citing works
Some Factors Affecting C14-Acetate Incorporation into Polyunsaturated Fatty Acids of Skin
Wilkinson, D. I. (1973) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12724457 · Cited by 5 · see citing works
Syndrome of ichthyosis, hepatosplenomegaly and cerebellar degeneration—steroid sulphatase activity
Dykes, P. J., Marks, R., & Harper, P. S. (1980) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1980.tb08154.x · Cited by 5 · see citing works
Profile of epidermal metabolic activity in autosomal dominant ichthyosis and small bowel disorders
Dykes, P. J., Marks, R., & Smith, P. D. (1978) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1978.tb03578.x · Cited by 5 · see citing works
Studies of the Lipids of Dog Skin. IV
Lipkin, G., Wheatley, V. R., Woo, T. H., & March, C. H. (1968) · Journal of Investigative Dermatology · doi:10.1038/jid.1968.74 · Cited by 5 · see citing works
Epidermal Lipogenesis in Ichthyosis
Cooper, M. F., McGibbon, D., & Shuster, S. (1978) · Springer eBooks · doi:10.1007/978-94-010-9851-9_3 · Cited by 4 · see citing works
Epidermal lipid biosynthesis in acne
Shuster, S., Cooper, M. F., McGibbon, D., & Wilson, P. (1980) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1980.tb06580.x · Cited by 4 · see citing works
Skin components: 14C acetate incorporation in vitro. With particular reference to lipid synthesis in the isolated (dissected) human sebaceous gland.
Summerly, R. (1974) · PubMed · Cited by 4 · see citing works
Self-citation
Fatty Acids of Hair Lipids of Germ Free and Germ Exposed Rats**From the Division of Dermatology, University of Minnesota Medical School, Minneapolis, Minnesota 55455.
Smith, Q. T., Fusaro, R. M., & Grande, D. (1965) · Journal of Investigative Dermatology · doi:10.1038/jid.1965.61 · Cited by 3 · see citing works

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Epidermal Lipids, Barrier Function, and Desquamation
Elias, P. M. (1983) · Journal of Investigative Dermatology · doi:10.1038/jid.1983.12 · Cited by 1,356 · see citing works
Barrier Function of the Skin: “La Raison d'Être” of the Epidermis
Madison, K. C. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12359.x · Cited by 1,192 · see citing works
Human stratum corneum lipids: characterization and regional variations
Lampe, M. A., Burlingame, A. L., Whitney, J., Williams, M. L., Brown, B. E., Roitman, E., & Elias, P. M. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38005-6 · Cited by 692 · see citing works
Structural and Lipid Biochemical Correlates of the Epidermal Permeability Barrier
Elias, P. M., & Menon, G. K. (1991) · Advances in lipid research · doi:10.1016/b978-0-12-024924-4.50005-5 · Cited by 677 · see citing works
Liposomes and niosomes as topical drug carriers: dermal and transdermal drug delivery
Schreier, H., & Bouwstra, J. A. (1994) · Journal of Controlled Release · doi:10.1016/0168-3659(94)90039-6 · Cited by 533 · see citing works
Presence of Intact Intercellular Lipid Lamellae in the Upper Layers of the Stratum Corneum
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Authors: Yardley, H. J., & Summerly, R.
Affiliations: Keele University (GB)
Royal Stoke University Hospital (GB)
Venue: Pharmacology & Therapeutics
Publisher: Elsevier BV
Published: 1981-01
Volume: 13
Issue: 2
Pages: 357-383
ISSN: 0163-7258 (ISSN-L)
DOI: 10.1016/0163-7258(81)90006-1
OpenAlex: W2005090658
Cited by: 267
References: 209
Citations by year: 2026: 1 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 8 · 2020: 2 · 2019: 1 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 11 · 2012: 4
FWCI: 4.14
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords: epidermis, skin lipids, lipid metabolism, lipid composition, skin diseases, stratum corneum
MeSH terms: Fatty Acids, Fatty Acids, Essential, Humans, Hydrocarbons, Ichthyosis, Keratins, Lipids, Phospholipids, Psoriasis, Skin, Skin Diseases, Skin Physiological Phenomena, Sphingolipids, Sterols, Subcellular Fractions, Waxes, Lipid Metabolism

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Lipid composition and metabolism in normal and diseased epidermis

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