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Do corticosteroids prevent post-herpetic neuralgia?
Abstract
SUMMARY: Forty otherwise healthy patients over 50 years of age with early, severe painful herpes zoster were randomly allocated to two groups for treatment. Twenty patients received prednisolone 40 mg daily with gradual reduction over a period of 4 weeks, whilst the other twenty patients received carbamazepine 100 mg four times daily. Thirteen of the twenty patients (65%) in the carbamazepine treated group developed post-herpetic neuralgia lasting up to 2 years, whilst only three of the twenty prednisolone treated patients (15%) had post-herpetic neuralgia lasting up to 6 months only. Thus the incidence and duration of post-herpetic neuralgia were considerably reduced in the prednisolone treated group. In neither group did disseminated zoster or other complications occur.
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Citations
Cited by
Neurologic Complications of the Reactivation of Varicella–Zoster Virus
Gilden, D. H., Kleinschmidt-DeMasters, B. K., LaGuardia, J. J., Mahalingam, R., & Cohrs, R. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003023420906 · Cited by 853
Postherpetic Neuralgia — Pathogenesis, Treatment, and Prevention
Kost, R. G., & Straus, S. E. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607043350107 · Cited by 641
Wood, M. J., Johnson, R. W., McKendrick, M. W., Taylor, J., Mandal, B. K., & Crooks, J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403313301304 · Cited by 401
Whitley, R. J., Weiss, H., Gnann Jr., J. W., Tyring, S., Mertz, G. J., Pappas, P. G., Schleupner, C. J., Hayden, F., Wolf, J., Soong, S.-J., et al. (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-125-5-199609010-00004 · Cited by 386
Post-herpetic neuralgia: Further post-mortem studies of cases with and without pain
Watson, C. P. N., Deck, J. H., Morshead, C., Van der Kooy, D., & Evans, R. J. (1991) · Pain · doi:10.1016/0304-3959(91)90124-g · Cited by 337
Metadata
- Authors
- KECZKES, K., & BASHEER, A. M.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 1980-05-01
- Volume
- 102
- Issue
- 5
- Pages
- 551-555
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- OpenAlex
- W2065266958
- Cited by
- 167
- References
- 0
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- KECZKES, K., & BASHEER, A. M. (1980). Do corticosteroids prevent post-herpetic neuralgia? British Journal of Dermatology. https://doi.org/10.1111/j.1365-2133.1980.tb07654.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
