Protease inhibitors protect growth factor activity in chronic wounds

Wlaschek, M.; Peus, D.; Achterberg, V.; Meyer-Ingold, W.; Scharffetter-Kochanek, K.

doi:10.1111/j.1365-2133.1997.tb03804.x

Cited by 81Wound Healing and TreatmentsProtease and Inhibitor MechanismsTGF-β signaling in diseases

Protease inhibitors protect growth factor activity in chronic wounds

Wlaschek, M., Peus, D., Achterberg, V., Meyer-Ingold, W., Scharffetter-Kochanek, K.·1997·British Journal of Dermatology

DOI 10.1111/j.1365-2133.1997.tb03804.x

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M. Wlaschek, D. Peus, V. Achterberg, W. Meyer‐Ingold, K. Scharffetter‐Kochanek; Protease inhibitors protect growth factor activity in chronic wounds, British Jo

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In chronic wounds, there is a marked increase in serine proteases that degrade matrix components including fibronectin and key growth factors required for extracellular matrix remodeling and cell growth.
“Last, in chronic wounds, there is a marked increase in serine proteases that degrades matrix components, including fibronectin, as well as various key growth factors, all of which are required for remodeling of the ECM and cell growth (38-41).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [39]

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Pierce, G. F., Tarpley, J. E., Tseng, J., BREADY, J. V., Chang, D., Kenney, W. C., Rudolph, R., Robson, M. C., Berg, J. S. V., & Reid, P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118169 · Cited by 226 · see citing works
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Rao, C. N., Ladin, D. A., Chilukuri, K., Woodley, D. T., Liu, Y. Y., & Hou, Z. Z. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12323503 · Cited by 108 · see citing works
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Falanga, V., Grinnell, F., Gilchrest, B. A., Maddox, Y. T., & Moshell, A. N. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12371745 · Cited by 87 · see citing works
Wound therapy: growth factors as agents to promote healing
Meyer‐Ingold, W. (1993) · Trends in biotechnology · doi:10.1016/0167-7799(93)90098-t · Cited by 76 · see citing works
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Grice, E. A., & Segre, J. A. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0106-3_4 · Cited by 124 · see citing works
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Baker, E. A., & Leaper, D. J. (2000) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2000.00392.x · Cited by 116 · see citing works
Molecular Pathophysiology of Chronic Wounds: Current State and Future DirectionsPreprint
Pastar, I., Balukoff, N. C., Marjanović, J., Chen, V. Y., Stone, R. C., & Tomic‐Canic, M. (2022) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041243 · Cited by 122 · see citing works
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Eming, S., Krieg, T., & Davidson, J. (2007) · Clinical Dermatology · doi:10.1016/j.clindermatol.2006.09.011 · Cited by 109 · see citing works
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Gabriel, A., Shores, J. T., Bernstein, B., de Leon, J., Kamepalli, R., Wolvos, T. A., Baharestani, M. M., & Gupta, S. C. (2009) · International Wound Journal · doi:10.1111/j.1742-481x.2009.00628.x · Cited by 95 · see citing works
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“Protease inhibitors, specifically targeting MMPs, have earlier been acknowledged as promising therapeutic strategy for the treatment of chronic wounds [116,117].”
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Distinct phenotype associated with a cryptic subtelomeric deletion of 19p13.3‐pter
Archer, H. L., Gupta, S., Enoch, S., Thompson, P., Rowbottom, A. W., Chua, I. C., Warren, S., Johnson, D., Ledbetter, D. H., Martin, C. L., et al. (2005) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30774 · Cited by 75 · see citing works
Guidelines for Managing Pressure Ulcers with Negative Pressure Wound Therapy
Gupta, S. C., Baharestani, M. M., Baranoski, S., de Leon, J., Engel, S. J., Mendez-Eastman, S. K., Niezgoda, J. A., & Pompeo, M. Q. (2004) · Advances in Skin & Wound Care · doi:10.1097/00129334-200411002-00001 · Cited by 73 · see citing works
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EDWARDS, J. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.06.003 · Cited by 67 · see citing works
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Jeschke, M. G., Sandmann, G. H., Schubert, T. E. O., & Klein, D. (2005) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2005.130316.x · Cited by 67 · see citing works
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Topical insulin application accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization
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Hardwicke, J., Moseley, R., Stephens, P., Harding, K. G., Duncan, R., & Thomas, D. W. (2010) · Molecular Pharmaceutics · doi:10.1021/mp9002656 · Cited by 60 · see citing works
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Tong, M., Tuk, B., Hekking, I. M., Vermeij, M., Barritault, D., & van Neck, J. W. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2009.00548.x · Cited by 58 · see citing works
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Lauer, G., Sollberg, S., Cole, M., Krieg, T. M., & Eming, S. A. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03545-7 · Cited by 48 · see citing works
Updates on Recent Clinical Assessment of Commercial Chronic Wound Care Products
Sharma, A., Sharma, D., & Zhao, F. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300556 · Cited by 47 · see citing works
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Jeschke, M. G., & Klein, D. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302229 · Cited by 46 · see citing works
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Eming, S., Krieg, T., & Davidson, J. (2004) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.4.9.1373 · Cited by 44 · see citing works
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He, C., Hughes, M. A., Cherry, G. W., & Arnold, F. (1999) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1999.00097.x · Cited by 41 · see citing works
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Darby, I. A., & Weller, C. D. (2016) · Wound Repair and Regeneration · doi:10.1111/wrr.12502 · Cited by 36 · see citing works
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Zillmer, R., Trøstrup, H., Karlsmark, T., Ifversen, P., & Ågren, M. S. (2011) · Archives of Dermatological Research · doi:10.1007/s00403-011-1164-6 · Cited by 30 · see citing works
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Jiang, D., Singh, K., Muschhammer, J., Schatz, S., Sindrilaru, A., Makrantonaki, E., Yu, Q., Wlaschek, M., & Scharffetter‐Kochanek, K. (2020) · EMBO Reports · doi:10.15252/embr.201949115 · Cited by 28 · see citing works
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Nuutila, K., Yang, L., Broomhead, M., Proppe, K., & Eriksson, E. K. (2018) · Wound Repair and Regeneration · doi:10.1111/wrr.3 · Cited by 25 · see citing works
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Connors, D., Gies, D., Lin, H., Gruskin, E. A., Mustoe, T. A., & Tawil, N. J. (2000) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2000.00292.x · Cited by 22 · see citing works
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Romanelli, M., & Mastronicola, D. (2002) · Journal of Wound Care · doi:10.12968/jowc.2002.11.8.26428 · Cited by 21 · see citing works
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Rzany, Naldi, Schäfer, Stern, S. C. M., & Williams, H. C. (1998) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1998.02245.x · Cited by 20 · see citing works
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Bhattacharyya, J., Mondal, G., Kuncha, M., Agawane, S. B., Sistla, R., Gangireddy, S. R., Madhavi, R. D., Reddy, P. K., Konda, V. R., Rao, S. R., et al. (2009) · Molecular Pharmaceutics · doi:10.1021/mp800231z · Cited by 19 · see citing works
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Kim, J. H., Dong, J., Le, B. H., Lonergan, Z. R., Gu, W., Girke, T., Zhang, W., Newman, D. K., & Martins‐Green, M. M. (2024) · Antioxidants · doi:10.3390/antiox13060655 · Cited by 18 · see citing works
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Iurassich, S., Rocco, D., & Aurilia, A. (2001) · International Journal of Dermatology · doi:10.1046/j.1365-4362.2001.01197.x · Cited by 12 · see citing works
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Tati, R., Nordin, S. L., Abdillahi, S. M., & Mörgelin, M. (2018) · Journal of Wound Care · doi:10.12968/jowc.2018.27.4.199 · Cited by 10 · see citing works
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Jeschke, M. G., Sandmann, G. H., Finnerty, C. C., Herndon, D. N., Pereira, C. T., Schubert, T. E. O., & Klein, D. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302582 · Cited by 10 · see citing works
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Kim, J. H., Ahamed, A., Chen, K., Lebig, E. G., Petros, B., Saeed, S., & Martins‐Green, M. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822238-6.00027-3 · Cited by 5 · see citing works
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Borges‐Costa, J., & Marques, M. S. (2013) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2011.05281.x · Cited by 5 · see citing works
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Sibbald, R. G., Snyder, R., Botros, M., Burrows, C., Coutts, P. M., D’Souza, L., Kuhnke, J. L., Labrecque, C., Laforet, K., Landis, S. J., et al. (2012) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000415344.22307.ba · Cited by 4 · see citing works
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Baran, R., Fouilloux, B., & Robert, C. (2012) · Blackwell Publishing Ltd eBooks · doi:10.1002/9781118286715.ch8 · Cited by 3 · see citing works
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Parks, W. C., & Schultz, G. S. (2000) · Springer eBooks · doi:10.1007/978-1-4612-1194-5_7 · Cited by 2 · see citing works
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Cullen, B., & Gefen, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-323-91775-9.00003-7 · Cited by 1 · see citing works
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Henshaw, F. R. (2014) · The Sydney eScholarship Repository (The University of Sydney)
Using Triticum vulgare in post-surgical treatment of chronic fibrosing interdigital pyoderma in a dog. Case report ¤ Uso de Triticum vulgare en tratamiento posquirúrgico de pioderma interdigital crónico fibrosante en un canino. Reporte de caso Utilização de Triticum vulgare no tratamento pós-cirúrgico de piodermite interdigital crônico fibrosante num canino. Relato de caso
González‐Domínguez, M., & Carmona, S. (2014)
Mechanismen der Wundheilung
Eming, S. A. (2009) · Fortschritte der praktischen Dermatologie und Venerologie · doi:10.1007/978-3-540-77148-7_5
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Wee, J. W. K. (2020) · doi:10.32657/10356/151419
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Scharffetter‐Kochanek, K. (1999) · Fortschritte der praktischen Dermatologie und Venerologie · doi:10.1007/978-3-662-01058-7_10
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Lozano, G. R. (2012) · doi:10.5821/dissertation-2117-94829
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Eming, S. A., Morgan, J. R., Davidson, J. M., & Krieg, T. M. (2000) · Springer eBooks · doi:10.1007/978-3-642-57191-6_156

Protease Activity Levels Associated with Healing Status of Chronic Wounds
Serena, T. E., Cullen, B., Bayliff, S. W., Gibson, M., DeMarco, D. C., Galbraith, J. W., Mancinelli, M., Sabo, M. J., & Samies, J. H. (2011) · Cited by 10 · see citing works
Ability of chronic wound fluids to degrade peptide growth factors is associated with increased levels of elastase activity and diminished levels of proteinase inhibitors
Yager, D. R., Chen, S. M., Ward, S. I., Olutoye, O. O., Diegelmann, R. F., & Cohen, I. K. (1997) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1997.50108.x · Cited by 309 · see citing works
166 The Role of Serine Proteases and their Inhibitors in Chronic Wounds
Cullen, B., Dunn, R., Lalikos, J. F., Nisbet, L., Essler, A., Damiani, P., Roth, T., & Sherrill, C. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2005.130216br.x
755 Pseudomonas aeruginosa proteases in planktonic and in vitro biofilm models – Implication for wound dressing development
Smola, H. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.02.798
TREATMENT OF CHRONIC PURULENT WOUNDS BASED ON PATHOGENETIC MECHANISMS INVOLVING PROTEASES AND PROTEASE INHIBITORS
Turdaliyevich, A. D. (2025) · Ethiopian International Journal of Multidisciplinary Research

Authors: Wlaschek, M., Peus, D., Achterberg, V., Meyer-Ingold, W., & Scharffetter-Kochanek, K.
Affiliations: University of Cologne (DE)
Beiersdorf (Germany) (DE)
ORCID: Wlaschek, M.
Venue: British Journal of Dermatology
Publisher: Oxford University Press (OUP)
Published: 1997-10
Volume: 137
Issue: 4
Pages: 646-663
ISSN: 0007-0963 (ISSN-L)
DOI: 10.1111/j.1365-2133.1997.tb03804.x
OpenAlex: W2036246700
Cited by: 81
References: 4
Citations by year: 2026: 1 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 5
FWCI: 4.68
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3151 d)
Locations: British Journal of Dermatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords: protease inhibitors, chronic wounds, growth factor activity, wound healing, proteolysis
MeSH terms: Chronic Disease, Female, Humans, Leg Ulcer, Male, Platelet-Derived Growth Factor, Protease Inhibitors, Wound Healing

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Protease inhibitors protect growth factor activity in chronic wounds

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