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Expression of the peripheral benzodiazepine receptor is decreased in skin cancers in comparison with normal skin
Abstract
Background The peripheral benzodiazepine receptor (PBR) is an 18-kDa protein receptor mainly found on the outer mitochondrial membrane of cells. The PBR plays a role in several cellular functions including haem synthesis, steroidogenesis, DNA synthesis, cell growth and differentiation, and apoptosis. PBR expression in normal skin correlates with proliferating, secretory and differentiated cellular structures. Increased or aberrant expression of PBR has been associated with aggressive behaviour in several tumour types including ovarian, colon and breast adenocarcinomas and glioblastoma. Objectives To determine whether changes in normal PBR distribution would be useful as markers for skin cancers or possible target sites for therapies such as photodynamic therapy (PDT), we used immunohistochemistry to evaluate PBR expression and distribution in normal and photodamaged skin (actinic keratoses), skin cancers (in situ and invasive squamous cell carcinomas and superficial, nodular, morphoeiform and mixed pattern basal cell carcinomas) and several benign epithelial proliferations. Methods A rabbit polyclonal antibody to a synthetic peptide fragment of the PBR was developed and characterized by enzyme-linked immunosorbent assay and Western blot analysis. The antibody was used to stain formalin-fixed and paraffin-embedded tissue samples (n = 157) by a routine avidin-biotin immunohistochemical technique. Sections were evaluated for antibody localization, distribution (0-4+) and reactio…
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Both pAb and mAb labeled some endothelial cells and smooth muscle cells.
“The pAb (but not mAb) labeled neuronal cell bodies with punctuate spots (B), and both pAb and mAb labeled some endothelial cells (F) and smooth muscle cells, in agreement with other studies [27;31].”
From Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain (2009) · cites this paper as [27]
The specificity of both antibodies has been confirmed by immunoblotting and subcellular localization has been verified by electron microscopy.
“The specificity of both antibodies has been confirmed by immunoblotting and subcellular localization has been verified by electron microscopy [27;28;54].”
From Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain (2009) · cites this paper as [27]
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Cosenza‐Nashat, M., Zhao, M. ‐., Suh, H. ‐., Morgan, J., Natividad, R., Morgello, S., & Lee, S. C. (2009) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.01006.x · Cited by 459
Self-citation
Metadata
- Authors
- Morgan, J., Oseroff, A. R., & Cheney, R. T.
- Affiliations
- Roswell Park Comprehensive Cancer Center (US)
- Corresponding author
- Morgan, J.
- ORCID
- Morgan, J.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-10
- Volume
- 151
- Issue
- 4
- Pages
- 846-856
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- OpenAlex
- W1965199845
- Cited by
- 19
- References
- 2
- Citations by year
- 2023: 1 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (P01CA055791, P30CA016056)
- Topics
- Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Dermatology › Cancer and Skin Lesions
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- translocator protein (TSPO), skin cancer, squamous cell carcinoma, basal cell carcinoma, actinic keratosis, heme biosynthesis, protoporphyrin IX, aminolaevulinic acid, photodynamic therapy, tumor differentiation, skin carcinogenesis, tumor markers, photodamage, mitochondrial outer membrane
- MeSH terms
- Basal Cell Carcinoma, Carcinoma, Squamous Cell, Humans, Keratosis, Neoplasm Proteins, Photochemotherapy, Photosensitivity Disorders, Precancerous Conditions, Prognosis, Receptors, GABA-A, Skin, Skin Diseases, Skin Neoplasms, Biomarkers, Tumor, Blotting, Western
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