The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Thrombosis and haemorrhage in polycythaemia vera and essential thrombocythaemia
Abstract
Summary: Despite decades of clinical and laboratory research, relatively little has been accomplished concerning the pathogenesis as well as the identification of risk factors for thrombosis and bleeding in myeloproliferative disorders. In polycythaemia vera, the pro‐thrombotic effect of an elevated haematocrit is well established. In contrast, thrombocytosis per se has not been similarly incriminated in essential thrombocythaemia. In both conditions, advanced age and the presence of a prior event identify thrombosis‐prone patients. There is increasing evidence to suggest an additional role by leucocytes that might partly explain the antithrombotic effects of myelosuppressive therapy. A substantial minority of affected patients display reduced levels of high molecular weight von Willebrand protein in the plasma during extreme thrombocytosis and it is believed that this might explain the bleeding diathesis of such patients. Recent controlled studies support the therapeutic value of hydroxyurea and aspirin in essential thrombocythaemia and polycythaemia vera, respectively. The current communication will address the incidence, phenotype, pathogenesis, risk factors, prevention, and treatment of both thrombosis and haemorrhage in these disorders.
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Cites
Collaboration, A. T. (2002) · BMJ · doi:10.1136/bmj.324.7329.71 · Cited by 6,943
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura
Levy, G. G., Nichols, W. C., Lian, E. C., Foroud, T., McClintick, J. N., McGee, B. M., Yang, A. Y., Siemieniak, D. R., Stark, K. R., Gruppo, R., et al. (2001) · Nature · doi:10.1038/35097008 · Cited by 1,749
The way I see it: House officers need formal career development
Connor, A. (2002) · BMJ · doi:10.1136/bmj.324.7336.s71 · Cited by 1,143
Editorial: Some Speculations on the Myeloproliferative Syndromes
DAMESHEK, W. (1951) · Blood · doi:10.1182/blood.v6.4.372.372 · Cited by 1,082
Efficacy and Safety of Low-Dose Aspirin in Polycythemia Vera
Landolfi, R., Marchioli, R., Kutti, J., Gisslinger, H., Tognoni, G., Patrono, C., & Barbui, T. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa035572 · Cited by 1,012
Galli, M., Luciani, D., Bertolini, G., & Barbui, T. (2003) · Blood · doi:10.1182/blood-2002-02-0441 · Cited by 972 · cited 1×
“Antiphospholipid antibodies, as measured by either by a clot-based assay (lupus anticoagulant) or enzyme-linked immunosorbent assay are established risk factors for both arterial and venous thrombotic disease (Galli et al, 2003).”
MethodPatrono, C., Coller, B., Dalen, J. E., Fitz Gerald, G. A., Fuster, V., Gent, M., Hirsh, J., & Roth, G. (2001) · Chest · doi:10.1378/chest.119.1_suppl.39s · Cited by 963
Steinberg, M. H., Barton, F., Castro, O., Pegelow, C. H., Ballas, S. K., Kutlar, A., Orringer, E., Bellevue, R., Olivieri, N., Eckman, J., et al. (2003) · JAMA · doi:10.1001/jama.289.13.1645 · Cited by 931
Furlan, M., Robles, R., & Lamie, B. (1996) · Blood · doi:10.1182/blood.v87.10.4223.bloodjournal87104223 · Cited by 895
Hydroxyurea for Patients with Essential Thrombocythemia and a High Risk of Thrombosis
Cortelazzo, S., Finazzi, G., Ruggeri, M., Vestri, O., Galli, M., Rodeghiero, F., & Barbui, T. (1995) · New England Journal of Medicine · doi:10.1056/nejm199504273321704 · Cited by 843
Cited by
Szczepiorkowski, Z. M., Winters, J. L., Bandarenko, N., Kim, H. C., Linenberger, M. L., Marques, M. B., Sarode, R., Schwartz, J., Weinstein, R., & Shaz, B. H. (2010) · Journal of Clinical Apheresis · doi:10.1002/jca.20240 · Cited by 508
Wolanskyj, A. P., Schwager, S. M., McClure, R. F., Larson, D. R., & Tefferi, A. (2006) · Mayo Clinic Proceedings · doi:10.4065/81.2.159 · Cited by 329
Self-citationCarobbio, A., Finazzi, G., Guerini, V., Spinelli, O., Delaini, F., Marchioli, R., Borrelli, G., Rambaldi, A., & Barbui, T. (2007) · Blood · doi:10.1182/blood-2006-09-046342 · Cited by 320
Hasselbalch, H. C. (2012) · Blood · doi:10.1182/blood-2011-11-394775 · Cited by 300
Inflammation and myeloproliferative neoplasms
Lussana, F., & Rambaldi, A. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.06.010 · Cited by 136
Metadata
- Authors
- Elliott, M. A., & Tefferi, A.
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 2005-01-24
- Volume
- 128
- Issue
- 3
- Pages
- 275-290
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- OpenAlex
- W1993230181
- Cited by
- 473
- References
- 56
- FWCI
- 12.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Elliott, M. A., & Tefferi, A. (2005). Thrombosis and haemorrhage in polycythaemia vera and essential thrombocythaemia. British Journal of Haematology. https://doi.org/10.1111/j.1365-2141.2004.05277.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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