Requirement for myeloid growth factors in the differentiation of acute promyelocytic leukaemia
Open accessAbstract
Summary: It is well known that the differentiation of acute promyelocytic leukaemia (APL) cells by all‐trans‐retinoic acid (ATRA) may be enhanced by myeloid growth factors, but the requirement for growth factors in this process is unclear. Our previous studies in multiple myeloma and non‐APL acute myeloid leukaemia demonstrated that lineage‐specific growth factors are required for the maximal activity of many pharmacologic differentiating agents in vitro. Thus, we studied whether the differentiation of APL is similarly dependent on growth factors. We found that the myeloid growth factors granulocyte colony‐stimulating factor or granulocyte‐macrophage colony‐stimulating factor markedly increased the differentiation of NB4 cells or APL blasts from clinical samples treated with ATRA, arsenic trioxide (ATO), or bryostatin‐1 as evidenced by the enhanced expression of myeloid surface antigens and the inhibition of clonogenic growth. Furthermore, myeloid growth factors were necessary for the differentiation of APL cells since the activity of each pharmacologic agent could be blocked by specific growth factor‐neutralizing antibodies. Each differentiating agent was active only at concentrations that inhibited cell cycling, suggesting that this property is also required for differentiation. These data demonstrate that both pharmacologic differentiating agents and myeloid growth factors are required, but neither sufficient, for the differentiation of APL cells. The combined use of pharmacologic differentiating agents and growth factors may improve the clinical efficacy of differentiation therapy in APL.
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ATRA and G/GM-CSF co-operate to promote myelomonocytic differentiation in murine pluripotent myeloid progenitor cells, different AML cell lines, as well as primary cells from patients with myeloid leukaemia.
“All-trans-retinoic acid and G/GM-CSF co-operate to promote myelomonocytic differentiation in murine pluripotent myeloid progenitor cells, different AML cell lines, as well as primary cells from patients with myeloid leukaemia (Matsui et al, 2005).”
From Unlocking the potential of retinoic acid in anticancer therapy (2014) · cites this paper as Matsui et al, 2005
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- Authors
- Matsui, W., Douglas Smith, B., Vala, M., Beal, N., Huff, C. A., Diehl, L. F., & Jones, R. J.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Matsui, William
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 2005-03
- Volume
- 128
- Issue
- 6
- Pages
- 853-862
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- OpenAlex
- W2053223000
- Cited by
- 23
- References
- 74
- Citations by year
- 2025: 1 · 2021: 1 · 2020: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2012: 2
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Haematology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5P30CA06973)
- National Cancer Institute (5P30 CA06973, P01-CA15396, P01CA015396, P30CA006973)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- acute promyelocytic leukemia, myeloid growth factors, granulocyte colony-stimulating factor, GM-CSF, all-trans retinoic acid, arsenic trioxide, bryostatin 1, NB4 cells, cell cycle inhibition
- MeSH terms
- Arsenic Trioxide, Antineoplastic Agents, Arsenicals, Cell Cycle, Cell Transformation, Neoplastic, Flow Cytometry, Growth Inhibitors, Humans, Oxides, Tretinoin, Leukemia, Promyelocytic, Acute, Granulocyte-Macrophage Colony-Stimulating Factor, Granulocyte Colony-Stimulating Factor, Apoptosis, Macrolides, Myelopoiesis, Cell Line, Tumor, Bryostatins
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