The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
PAD combination therapy (PS‐341/bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma
Open accessAbstract
Summary: Bortezomib (formerly PS‐341) has significant activity in patients with relapsed multiple myeloma (MM), its efficacy is increased with the addition of dexamethasone and it demonstrates synergy with doxorubicin, thus providing the rationale for combination therapy with bortezomib, doxorubicin and dexamethasone (PAD). Patients with untreated MM received four 21‐d cycles of PAD, comprising bortezomib 1·3 mg/m 2 on days 1, 4, 8 and 11, along with dexamethasone 40 mg on days 1–4, 8–11 and 15–18 during cycle 1 and days 1–4 during cycles 2–4. During days 1–4, patients also received 0, 4·5 or 9 mg/m 2 of doxorubicin at dose levels 1, 2, and 3 respectively. Following peripheral blood stem cell (PBSC) collection, patients received high‐dose melphalan (MEL200) with PBSC transplantation (PBSCT). After PAD induction alone, 20 of 21 patients (95%) achieved at least a partial response (PR), including complete response (CR) in five patients (24%). Twenty of 21 had PBSC mobilized, and 18 of 20 received MEL200/PBSCT. In an intention‐to‐treat analysis, response rates were: CR 43%, near CR 14%, very good PR 24%, PR 14% and stable disease 5%. PAD was effective, did not prejudice subsequent PBSC collection, and should be further evaluated in prospective randomized trials.
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A Phase 2 Study of Bortezomib in Relapsed, Refractory Myeloma
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Self-citationAntitumor Activity of Thalidomide in Refractory Multiple Myeloma
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Cited by
International uniform response criteria for multiple myeloma
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THE PROTEASOME AND PROTEASOME INHIBITORS IN CANCER THERAPY
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Metadata
- Authors
- Oakervee, H. E., Popat, R., Curry, N., Smith, P., Morris, C., Drake, M., Agrawal, S., Stec, J., Schenkein, D., Esseltine, D., & Cavenagh, J. D.
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 2005-06
- Volume
- 129
- Issue
- 6
- Pages
- 755-762
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- OpenAlex
- W2025253157
- Cited by
- 317
- References
- 37
- FWCI
- 29.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: PAD combination therapy (PS‐341/bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma. https://app.cochat.ai/papers/10.1111/j.1365-2141.2005.05519.x
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- Oakervee, H. E., Popat, R., Curry, N., Smith, P., Morris, C., Drake, M., Agrawal, S., Stec, J., Schenkein, D., Esseltine, D., & Cavenagh, J. D. (2005). PAD combination therapy (PS‐341/bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma. British Journal of Haematology. https://doi.org/10.1111/j.1365-2141.2005.05519.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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