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Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers
Abstract
Abstract. Fibroblast colonies (clones) were obtained by explantation of bone marrow single‐cell suspensions and were used to establish multicolony and single‐colony derived fibroblast cultures by successive passaging of either pooled or individual colonies. When transplanted in diffusion chambers after 20–30 cell doublings in vitro, the descendants of fibroblast colony‐forming cells (FCFC), whether grown from single or pooled colonies, retained the ability for bone and cartilage formation. The content of osteogenic precursors in the cultured progeny significantly outnumbered the initiating FCFC. Thus the high proliferative potential of bone marrow FCFC and their ability to serve as common precursors of bone and cartilage‐forming cells makes them probable candidates for the role of osteogenic stem cells.
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Cited by
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Caplan, A. I., & Correa, D. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.06.008 · Cited by 1,682
Mesenchymal stem cells: immune evasive, not immune privileged
Ankrum, J. A., Ong, J. F., & Karp, J. M. (2014) · Nature Biotechnology · doi:10.1038/nbt.2816 · Cited by 1,531
TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation
Tang, Y., Wu, X., Lei, W., Pang, L., Wan, C., Shi, Z., Zhao, L., Nagy, T. R., Peng, X., Hu, J., et al. (2009) · Nature Medicine · doi:10.1038/nm.1979 · Cited by 1,165
Stem cell-based therapy for human diseases
Hoang, D. M., Pham, P. T., Bach, T. Q., Ngo, A. T. L., Nguyen, Q. T., Phan, T. T. K., Nguyen, G. H., Le, P. T. T., Hoang, V. T., Forsyth, N. R., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01134-4 · Cited by 1,074
Metadata
- Authors
- Friedenstein, A. J., Chailakhyan, R. K., & Gerasimov, U. V.
- Venue
- Cell Proliferation
- Publisher
- Wiley
- Published
- 1987-05
- Volume
- 20
- Issue
- 3
- Pages
- 263-272
- ISSN
- 0960-7722 (ISSN-L)
- 1365-2184
- OpenAlex
- W1985905343
- Cited by
- 983
- References
- 0
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Friedenstein, A. J., Chailakhyan, R. K., & Gerasimov, U. V. (1987). Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers. Cell Proliferation. https://doi.org/10.1111/j.1365-2184.1987.tb01309.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
