The MSC: An Injury Drugstore
Open accessAbstract
Now that mesenchymal stem cells (MSCs) have been shown to be perivascular in vivo, the existing traditional view that focuses on the multipotent differentiation capacity of these cells should be expanded to include their equally interesting role as cellular modulators that brings them into a broader therapeutic scenario. We discuss existing evidence that leads us to propose that during local injury, MSCs are released from their perivascular location, become activated, and establish a regenerative microenvironment by secreting bioactive molecules and regulating the local immune response. These trophic and immunomodulatory activities suggest that MSCs may serve as site-regulated "drugstores" in vivo.
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Upon tissue damage, endogenous MSCs migrate from their perivascular location and create a regenerative microenvironment through the secretion of bioactive factors and modulation of the immune cell response.
“upon tissue damage, endogenous MSCs migrate from their perivascular location and create a regenerative microenvironment through the secretion of bioactive factors and the modulation of the immune cell response [11], [12].”
From Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? (2025) · cites this paper as [11]
In “The Drugstore” (page not provided), the authors propose that vessel damage releases perivascular cells, which then secrete bioactive molecules that regulate immune cells and establish a regenerative microenvironment. The citing sentence presents this proposed model as an established response to tissue damage, rather than retaining the source’s qualification. (LLM, conf=0.84)
Experimental — accuracy not yet measuredMesenchymal stem/stromal cells can be obtained from numerous human tissues and can differentiate into a wide variety of cell types.
“Mesenchymal stem/stromal cells (MSCs) can be obtained from numerous human tissues and can differentiate into a wide variety of cell types [15].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [15]
The Mesenchymal Stem Cell (MSC) section reports isolation from human bone marrow and describes adipose-derived cells; The Drugstore section also discusses MSCs from fat, placenta, umbilical cord and muscle. The paper documents differentiation into multiple mesenchymal lineages in vitro, but says that in vivo multipotency is not definitive. The claim omits those limits when it says MSCs can differentiate into a wide variety of cell types. (LLM, conf=0.84)
Experimental — accuracy not yet measured
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- Authors
- Caplan, A. I., & Correa, D.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Caplan, Arnold I.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 9
- Issue
- 1
- Pages
- 11-15
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC3144500
- OpenAlex
- W2018258390
- Cited by
- 1,682
- References
- 3
- Citations by year
- 2026: 80 · 2025: 87 · 2024: 85 · 2023: 105 · 2022: 104 · 2021: 155 · 2020: 147 · 2019: 130 · 2018: 137 · 2017: 122 · 2016: 144 · 2015: 135 · 2014: 96 · 2013: 85 · 2012: 60
- FWCI
- 40.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P01AR053622)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- mesenchymal stem cells, perivascular localization, injury response, immunomodulation, regenerative microenvironment, trophic activity, local immune response, stem cell activation
- MeSH terms
- Animals, Clinical Trials as Topic, Humans, Treatment Outcome, Pericytes, Models, Animal, Mesenchymal Stem Cells, Cell- and Tissue-Based Therapy
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