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Cytotoxicity of clove (Syzygium aromaticum) oil and its major components to human skin cells
Open accessAbstract
Abstract. The essential oil extracted from clove (Syzygium aromaticum) is used as a topical application to relieve pain and promote healing in herbal medicine and also finds use in the fragrance and flavouring industries. Clove oil has two major components, eugenol and β‐caryophyllene, which constitute 78% and 13% of the oil, respectively. Clove oil and these components are generally recognized as ‘safe’, but the in‐vitro study here demonstrates cytotoxic properties of both the oil and eugenol, towards human fibroblasts and endothelial cells. Clove oil was found to be highly cytotoxic at concentrations as low as 0.03% (v/v) with up to 73% of this effect attributable to eugenol. β‐caryophyllene did not exhibit any cytotoxic activity, indicating that other cytotoxic components may also exist within the parent oil.
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Cited by
El-Saber Batiha, G., Alkazmi, L. M., Wasef, L. G., Beshbishy, A. M., Nadwa, E. H., & Rashwan, E. K. (2020) · Biomolecules · doi:10.3390/biom10020202 · Cited by 643
Anticancer activity of essential oils: a review
Bhalla, Y., Gupta, V. K., & Jaitak, V. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6267 · Cited by 276
Han, X., & Parker, T. L. (2017) · Pharmaceutical Biology · doi:10.1080/13880209.2017.1314513 · Cited by 168
Ahmed, L. I., Ibrahim, N., Abdel-Salam, A. B., & Fahim, K. M. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101177 · Cited by 83
Anti-inflammatory and wound healing potential of a clove oil emulsion
Banerjee, K., Madhyastha, H., Sandur V., R., N.T., M., N., T., & Thiagarajan, P. (2020) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2020.111102 · Cited by 81
Metadata
- Authors
- Prashar, A., Locke, I. C., & Evans, C. S.
- Venue
- Cell Proliferation
- Publisher
- Wiley
- Published
- 2006-07-07
- Volume
- 39
- Issue
- 4
- Pages
- 241-248
- ISSN
- 0960-7722 (ISSN-L)
- 1365-2184
- OpenAlex
- W2108580813
- Cited by
- 260
- References
- 0
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cytotoxicity of clove (Syzygium aromaticum) oil and its major components to human skin cells. https://app.cochat.ai/papers/10.1111/j.1365-2184.2006.00384.x
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- Prashar, A., Locke, I. C., & Evans, C. S. (2006). Cytotoxicity of clove (Syzygium aromaticum) oil and its major components to human skin cells. Cell Proliferation. https://doi.org/10.1111/j.1365-2184.2006.00384.x
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