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Cited by 329

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Immunological changes during specific immunotherapy of grass pollen allergy: reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T‐cell clones specific for Phi p 1, a major grass pollen allergen

EBNER, C., SIEMANN, U., BOHLE, B., WILLHEIM, M., WIEDERMANN, U., SCHENK, S., KLOTZ, F., EBNER, H., KRAFT, D., SCHEINER, O.·1997·Clinical & Experimental Allergy
DOI 10.1111/j.1365-2222.1997.tb01252.x
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Abstract

Summary: Background and Objective The mechanisms operative in specific immunotherapy (SIT) of Type I allergy are not completely understood. In the present study we evaluated immunological changes during SIT in pollinosis. Method Eight patients suffering from pollinosis (monosensitized to grass pollen) were treated with conventional SIT. All subjects had IgE specific for Phi p 1. a major allergen of timothy grass. In vitro changes in the immunological reactivity to grass pollen extract and to recombinant Phi p 1 were evaluated. Subjects were examined at three occasions: before, after 3 months and after I year of SIT. Results Serological analysis revealed a marked increase of grass pollen‐ and Phi p 1‐specific IgG, titres of specific IgE did not change significantly. Lymphoproliferative responses to grass pollen extract and rPhl p 1 were reduced already after 3 months of treatment. Accordingly, the cloning efficiency for Ph1 p 1‐specific T‐cell clones (TCC) dropped markedly in all patients. The majority of allergen‐specific TCC raised before SIT revealed a TH 2‐like pattern of cytokine production. TCC established after SIT revealed TH 1 characteristics. This shift was due to a decrease in IL‐4 rather than an increase in IFN‐production by T cells. Investigations of the epitopes recognized by T cells before and after SIT did not reveal the outgrowth of new (ldquo;protecting”) specificities. We could not observe induction of allergen‐speeific CD8+ lymphocytes (supressor cells). Conclusion Our data indicate that — on the level of TH lymphocytes — SIT induces tolerance to the allergen and a modulation of the cytokine pattern produced in response to allergen stimulation.

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Crossref · 10.1111/j.1365-2222.1997.tb01252.x

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Metadata

Authors
EBNER, C., SIEMANN, U., BOHLE, B., WILLHEIM, M., WIEDERMANN, U., SCHENK, S., KLOTZ, F., EBNER, H., KRAFT, D., & SCHEINER, O.
Venue
Clinical & Experimental Allergy
Publisher
Wiley
Published
1997-09
Volume
27
Issue
9
Pages
1007-1015
ISSN
  • 0954-7894 (ISSN-L)
  • 1365-2222
DOI
10.1111/j.1365-2222.1997.tb01252.x
OpenAlex
W2021399618
Cited by
329
References
33
FWCI
6.20
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Immunological changes during specific immunotherapy of grass pollen allergy: reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T‐cell clones specific for Phi p 1, a major grass pollen allergen. https://app.cochat.ai/papers/10.1111/j.1365-2222.1997.tb01252.x
The paper
EBNER, C., SIEMANN, U., BOHLE, B., WILLHEIM, M., WIEDERMANN, U., SCHENK, S., KLOTZ, F., EBNER, H., KRAFT, D., & SCHEINER, O. (1997). Immunological changes during specific immunotherapy of grass pollen allergy: reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T‐cell clones specific for Phi p 1, a major grass pollen allergen. Clinical & Experimental Allergy. https://doi.org/10.1111/j.1365-2222.1997.tb01252.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.