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Cited by 2,768

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Predominant TH2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

Robinson, Douglas S., Hamid, Qutayba, Ying, Sun, Tsicopoulos, Anne, Barkans, Julia, Bentley, Andrew M., Corrigan, Christopher, Durham, Stephen R., Kay, A. Barry·1992·New England Journal of Medicine
DOI 10.1056/nejm199201303260504
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Abstract

BACKGROUND: In atopic asthma, activated T helper lymphocytes are present in bronchial-biopsy specimens and bronchoalveolar-lavage (BAL) fluid, and their production of cytokines may be important in the pathogenesis of this disorder. Different patterns of cytokine release are characteristic of certain subgroups of T helper cells, termed TH1 and TH2, the former mediating delayed-type hypersensitivity and the latter mediating IgE synthesis and eosinophilia. The pattern of cytokine production in atopic asthma is unknown. METHODS: We assessed cells obtained by BAL in subjects with mild atopic asthma and in normal control subjects for the expression of messenger RNA (mRNA) for interleukin-2, 3, 4, and 5, granulocyte-macrophage colony-stimulating factor (GM-CSF), and interferon gamma by in situ hybridization with 32P-labeled complementary RNA. Localization of mRNA to BAL T cells was assessed by simultaneous in situ hybridization and immunofluorescence and by in situ hybridization after immunomagnetic enrichment or depletion of T cells. RESULTS: As compared with the control subjects, the subjects with asthma had more BAL cells per 1000 cell that were positive for mRNA for interleukin-2 (P less than 0.05), 3 (P less than 0.01), 4 (P less than 0.001), and 5 (P less than 0.001) and GM-CSF (P less than 0.001). There was no significant difference between the two groups in the number of cells expressing mRNA for interferon gamma. In the subjects with asthma, mRNA for interleukin-4 and 5 was expressed predominantly by T lymphocytes. CONCLUSIONS: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.

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Metadata

Authors
Robinson, D. S., Hamid, Q., Ying, S., Tsicopoulos, A., Barkans, J., Bentley, A. M., Corrigan, C., Durham, S. R., & Kay, A. B.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1992-01-30
Volume
326
Issue
5
Pages
298-304
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm199201303260504
OpenAlex
W2315018741
Cited by
2,768
References
31
FWCI
66.62
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Predominant TH2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma. https://app.cochat.ai/papers/10.1056/nejm199201303260504
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Robinson, D. S., Hamid, Q., Ying, S., Tsicopoulos, A., Barkans, J., Bentley, A. M., Corrigan, C., Durham, S. R., & Kay, A. B. (1992). Predominant TH2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma. New England Journal of Medicine. https://doi.org/10.1056/nejm199201303260504

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.