Topical corticosteroid inhibits interleukin‐4, ‐5 and ‐13 in nasal secretions following allergen challenge
Open accessAbstract
Summary: Background Cytokines and chemokines produced by allergen‐reactive T‐helper type 2 (Th2) cells may be pivotal to the pathophysiology of allergic disorders. Objective This study was performed to assess the effect of 7 days of topical corticosteroid on nasal allergen challenge (NAC) in terms of eosinophils, cytokines and chemokines obtained by nasal lavage and filter paper methods. Methods Patients with grass pollen seasonal‐allergic rhinitis (n=13) out of season received nasal challenge following matched placebo (twice daily into each nostril for 7 days) and fluticasone propionate (100 μg twice daily into each nostril for 7 days). Chemokine and cytokine levels were analysed using a sensitive automated bead immunoassay system at intervals up to 8 h after NAC. Results Levels of cytokines and chemokines from filter paper were generally higher than from nasal lavage. Fluticasone propionate caused a reduction in symptoms, total leukocyte counts and eosinophils, and abrogation of IL‐4, IL‐5, IL‐6 and IL‐13 responses in the filter paper taken in the late phase (P<0.05 for IL‐4 and IL‐13, P<0.01 for IL‐5 and IL‐6). Levels of chemokines (eotaxin, RANTES, MCP‐1, MIP‐1α, IL‐8 and IP‐10) were also reduced in the late phase (P<0.01 at 8 h). However, levels of IL‐2, IL‐3, IL‐7, IL‐12 (p40 and p70), ‐15, TNF‐α, IFN‐γ and GM‐CSF were not affected. Conclusion Fluticasone propionate has selective inhibitory effects on Th2 cytokine synthesis following nasal challenge, while also decreasing release of chemokines, but not affecting levels of Th1 cytokines.
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Levels of chemokines TARC/CCL17, MDC/CCL22, eotaxin, RANTES, MCP-1, and MIP-1α are elevated after nasal allergen challenge.
“Similarly, levels of chemokines such as thymus-regulated and activation-regulated chemokine (TARC, CCL17), macrophage derived chemokine (MDC, CCL22), eotaxin, RANTES, MCP-1, and macrophage inflammatory protein (MIP)-1α were elevated.388-391”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [388]
The Results section ('Effects of nasal allergen in placebo group compared with baseline'; page not provided) reports post-challenge increases in eotaxin, RANTES, MCP-1, and MIP-1α. The provided passages do not report increases in TARC/CCL17 or MDC/CCL22, so the source supports only four of the six listed chemokines. (LLM, conf=0.88)
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- Authors
- Erin, E. M., Zacharasiewicz, A. S., Nicholson, G. C., Tan, A. J., Higgins, L. A., Williams, T. J., Murdoch, R. D., Durham, S. R., Barnes, P. J., & Hansel, T. T.
- Affiliations
- Imperial College London (GB)
- GlaxoSmithKline (United Kingdom) (GB)
- Corresponding author
- Hansel, T. T.
- ORCID
- Venue
- Clinical & Experimental Allergy
- Publisher
- Wiley
- Published
- 2005-12
- Volume
- 35
- Issue
- 12
- Pages
- 1608-1614
- ISSN
- 0954-7894 (ISSN-L)
- 1365-2222
- OpenAlex
- W2081992291
- Cited by
- 76
- References
- 37
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 5 · 2014: 8 · 2013: 5 · 2012: 8
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical & Experimental Allergy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- topical corticosteroids, fluticasone propionate, allergic rhinitis, grass pollen allergy, nasal allergen challenge, Th2 cytokines, IL-4, IL-5, IL-13, interleukin-6, chemokines, eosinophils, nasal secretions, Th1 cytokines
- MeSH terms
- Fluticasone, Adrenal Cortex Hormones, Adult, Allergens, Analysis of Variance, Androstadienes, Female, Poaceae, Rhinitis, Allergic, Seasonal, Humans, Interleukins, Male, Nasal Mucosa, Nasal Provocation Tests, Pollen, Interleukin-4, Interleukin-5, Single-Blind Method, Nasal Lavage Fluid, Interleukin-13
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