Rhinitis symptoms caused by grass pollen are associated with elevated basophile allergen sensitivity and a larger grass‐specific immunoglobulin E fraction
Open accessAbstract
Summary: Background: The mechanisms responsible for the difference between clinically irrelevant IgE‐sensitization and allergic rhinitis are not fully understood. Objective: We evaluated the humoral and cellular mechanisms that may be associated with the presence of allergic rhinitis symptoms. Methods: We selected 26 subjects with positive grass pollen skin tests and IgE antibodies to T imothy (g6) and the major grass allergens rPhl p 1, 5b. Fourteen of those patients reported a history of allergic rhinitis. During winter, we performed a grass pollen CD 63 basophile activation test using four log allergen concentrations, followed by a grass nasal provocation test (NPT). We obtained symptom scores in the subsequent pollination season. Results: We showed that subjects with a positive NPT have significantly higher CD 63 basophile grass pollen responsiveness than NPT‐negative subjects, preferably at submaximal allergen concentrations, which represent cellular sensitivity. Moreover, basophile sensitivity positively correlated with the size of the grass‐specific IgE fraction in relation to total IgE, and it was highly predictive of allergic rhinitis symptoms in the following pollination season. Conclusion and Clinical Relevance: Allergic rhinitis symptoms are significantly associated with allergen‐specific basophile sensitivity. In vitro evaluation of basophile sensitivity should prove useful for distinguishing clinical phenotype of allergic sensitization.
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Basophil sensitivity, measured as EC50 or CD-sens, is a marker for the treatment effect of allergen immunotherapy and anti-IgE treatment.
“There is good evidence to suggest that basophil sensitivity (EC50, or eliciting concentration at which 50% of basophils respond; also named CD-sens if it is inverted and multiplied by 100) is a marker for treatment effect of AIT969-971,975-977 and anti-IgE treatment.975”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [976]
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International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
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- Authors
- Zidarn, M., Košnik, M., Šilar, M., Grahek, A., & Korošec, P.
- Affiliations
- University Clinic of Pulmonary and Allergic Diseases Golnik (SI)
- Corresponding author
- Korošec, P.
- Venue
- Clinical & Experimental Allergy
- Publisher
- Wiley
- Published
- 2011-08-22
- Volume
- 42
- Issue
- 1
- Pages
- 49-57
- ISSN
- 0954-7894 (ISSN-L)
- 1365-2222
- OpenAlex
- W2122166675
- Cited by
- 18
- References
- 29
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 4
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical & Experimental Allergy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- allergic rhinitis, grass pollen allergy, basophil activation, CD63, specific IgE, timothy grass, nasal provocation test, IgE sensitization
- MeSH terms
- Adult, Allergens, Basophils, Female, Rhinitis, Allergic, Seasonal, Humans, Immunoglobulin E, Male, Middle Aged, Nasal Provocation Tests, Plant Proteins, Pollen, Severity of Illness Index, Phleum, Young Adult
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