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Trichuris suis ova therapy for allergic rhinitis does not affect allergen‐specific cytokine responses despite a parasite‐specific cytokine response
Abstract
Summary: Background: Parasitic helminths have been shown to reduce inflammation in most experimental models of allergic disease, and this effect is mediated via cytokine responses. However, in humans, the effects of controlled helminth infection on cytokine responses during allergy have not been studied. Objective: The aim was to investigate whether infection with the nematode parasite T richuris suis alters systemic cytokine levels, cellular cytokine responses to parasite antigens and pollen allergens and/or the cytokine profile of allergic individuals. Methods: In a randomized double‐blinded placebo‐controlled clinical trial ( UMIN trial registry, Registration no. R000001298, Trial ID UMIN 000001070, URL : http://www.umin.ac.jp/map/english ), adults with grass pollen‐induced allergic rhinitis received three weekly doses of 2500 T richuris suis ova ( n = 45) or placebo ( n = 44) over 6 months. IFN ‐γ, TNF ‐α, IL ‐4, IL ‐5, IL ‐10 and IL ‐13 were quantified via cytometric bead array in plasma. Cytokines, including active TGF ‐β, were also quantified in supernatants from peripheral blood mononuclear cells cultured with parasite antigens or pollen allergens before, during and after the grass pollen season for a sub‐cohort of randomized participants ( T . suis ova‐treated, n = 12, Placebo‐treated, n = 10). Results: Helminth infection induced a Th2‐polarized cytokine response comprising elevated plasma IL ‐5 and parasite‐specific IL ‐4, IL ‐5 and IL ‐13, and a global shift in the profile of systemic cytokine responses. Infection also elicited high levels of the regulatory cytokine IL ‐10 in response to T . suis antigens. Despite increased production of T . suis ‐specific cytokines in T . suis ova‐treated participants, allergen‐specific cytokine responses during the grass pollen season and the global profile of PBMC cytokine responses were not affected by T . suis ova treatment. Conclusions and Clinical Relevance: This study suggests that cytokines induced by T richuris suis ova treatment do not alter allergic reactivity to pollen during the peak of allergic rhinitis symptoms.
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“In Fig 5, 49 an analysis using the Protein Analysis Through Evolutionary Relationships, version 11, 50 is presented, showing different pathways related to the main genes described in genome-wide association studies (GWASs) to date, in which one can observe 3 of the top 4 pathways linked to asthma are related to interleukin signaling and inflammation.”
From Global issues in allergy and immunology: Parasitic infections and allergy (2017) · cites this paper as [49]
In the citing paper
“Although T suis infection generated a measurable antiparasite response, infection did not affect allergen-specific responses.49”
From Global issues in allergy and immunology: Parasitic infections and allergy (2017) · cites this paper as [49]
In the citing paper
“Although T suis infection generated a measurable antiparasite response, infection did not affect allergen-specific responses.49”
From Global issues in allergy and immunology: Parasitic infections and allergy (2017) · cites this paper as [49]
In the citing paper
“A randomized controlled trial tested the efficacy of T suis for the treatment of allergic rhinitis in Denmark but showed no efficacy.”
From Global issues in allergy and immunology: Parasitic infections and allergy (2017) · cites this paper as [49]
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Cited by
Sorted by citations
Global issues in allergy and immunology: Parasitic infections and allergy
Cruz, A. A., Cooper, P. J., Figueiredo, C. A., Alcantara-Neves, N. M., Rodrigues, L. C., & Barreto, M. L. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.09.005 · Cited by 82
Metadata
- Authors
- Bourke, C. D., Mutapi, F., Nausch, N., Photiou, D. M. F., Poulsen, L. K., Kristensen, B., Arnved, J., Rønborg, S., Roepstorff, A., Thamsborg, S., Kapel, C., Melbye, M., & Bager, P.
- Affiliations
- Institute of Immunology and Infection Research School of Biological Sciences University of Edinburgh Edinburgh UK
- Allergy Clinic National University Hospital Copenhagen Denmark
- Phadia ApS, Allerød Copenhagen Denmark
- Pulmonology and Allergy Clinic of Copenhagen Copenhagen Denmark
- Department of Veterinary Disease Biology Faculty of Life Sciences University of Copenhagen Copenhagen Denmark
- Department of Agriculture and Ecology Faculty of Life Sciences University of Copenhagen Frederiksberg Denmark
- Statens Serum Institut, Department of Epidemiology Research Copenhagen Denmark
- Venue
- Clinical & Experimental Allergy
- Publisher
- Wiley
- Published
- 2012-10-29
- Volume
- 42
- Issue
- 11
- Pages
- 1582-1595
- ISSN
- 0954-7894
- 1365-2222
- Cited by
- 26
- References
- 2
- Language
- en
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- Bourke, C. D., Mutapi, F., Nausch, N., Photiou, D. M. F., Poulsen, L. K., Kristensen, B., Arnved, J., Rønborg, S., Roepstorff, A., Thamsborg, S., Kapel, C., Melbye, M., & Bager, P. (2012). Trichuris suis ova therapy for allergic rhinitis does not affect allergen‐specific cytokine responses despite a parasite‐specific cytokine response. Clinical & Experimental Allergy. https://doi.org/10.1111/j.1365-2222.2012.04063.x
