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Localized scleroderma-response to 1,25-dihydroxyvitamin D3
Abstract
1,25-Dihydroxyvitamin D3 [1,25(OH)2 D3] may be an immunomodulatory drug which could have a role in controlling collagen deposition, and inducing reversal of fibrosis in some tissues. These observations prompted a study of the possible use of this hormone for the treatment of scleroderma. A 35-year-old woman, who had been suffering from localized scleroderma for 2 years, was given oral 1,25(OH)2 D3 for 6 months. The effects of the treatment were evaluated using clinical and physical measurements (skin thickness, extensibility properties of the skin). The evolution of the patient's condition during the 6-month therapy suggests that 1,25(OH)2 D3 is beneficial in localized scleroderma. The mechanisms of action are discussed in relation to the literature, which suggests both immunoregulatory and inhibitory effects on fibroblast growth.
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Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population.
(1995) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040269 · Cited by 1,950
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Philippeos, C., Telerman, S. B., Oulès, B., Pisco, A. O., Shaw, T. J., Elgueta, R., Lombardi, G., Driskell, R. R., Soldin, M., Lynch, M. D., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.01.016 · Cited by 454
Metadata
- Authors
- HUMBERT, P. G., DUPOND, J. L., ROCHEFORT, A., VASSELET, R., LUCAS, A., LAURENT, R., & AGACHE, P.
- Venue
- Clinical and Experimental Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-09
- Volume
- 15
- Issue
- 5
- Pages
- 396-398
- ISSN
- 0307-6938 (ISSN-L)
- 1365-2230
- OpenAlex
- W2091030455
- Cited by
- 612
- References
- 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Localized scleroderma-response to 1,25-dihydroxyvitamin D3. https://app.cochat.ai/papers/10.1111/j.1365-2230.1990.tb02127.x
- The paper
- HUMBERT, P. G., DUPOND, J. L., ROCHEFORT, A., VASSELET, R., LUCAS, A., LAURENT, R., & AGACHE, P. (1990). Localized scleroderma-response to 1,25-dihydroxyvitamin D3. Clinical and Experimental Dermatology. https://doi.org/10.1111/j.1365-2230.1990.tb02127.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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